Promoter methylation study of the H37/RBM5 tumor suppressor gene from the 3p21.3 human lung cancer tumor suppressor locus

Human Genetics

Volumn 123, Issue 1, 2008, Pages 55-64

  Oh, Juliana J ^a   Boctor, Baher N ^a,c   Jimenez, Cynthia A ^a,d   Lopez, Roberto ^a,d   Koegel, Ashley K ^a   Taschereau, Eileen O ^a   Phan, Diana T ^a   Jacobsen, Steven E ^b   Slamon, Dennis J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; RNA BINDING PROTEIN; RNA BINDING PROTEIN 5; RNA BINDING PROTEIN 6; UNCLASSIFIED DRUG;

ARTICLE; CANCER GENETICS; CHROMOSOME 3P; CONTROLLED STUDY; CPG ISLAND; EPIGENETICS; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE IDENTIFICATION; GENE INACTIVATION; GENE LOCUS; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HAPLOIDY; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG CARCINOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; PROTEIN PROCESSING; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; DNA, NEOPLASM; DNA-BINDING PROTEINS; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA-BINDING PROTEINS; TUMOR SUPPRESSOR PROTEINS;

EID: 38949214809     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-007-0449-5     Document Type: Article

References (34)

1. Carboni GL, Gao B, Nishizaki M, Xu K, Minna JD, Roth JA, Ji L (2003) CACNA2D2-mediated apoptosis in NSCLC cells is associated with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity. Oncogene 22:615-626
2. Chow LS, Lo KW, Kwong J, To KF, Tsang KS, Lam CW, Dammann R, Huang DP (2004) RASSF1A is a target tumor suppressor from 3p21.3 in nasopharyngeal carcinoma. Int J Cancer 109:839-847
3. Dammann R, Li C, Yoon JH, Chin PL, Bates S, Pfeifer GP (2000) Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet 25:315-319
4. Dammann R, Schagdarsurengin U, Strunnikova M, Rastetter M, Seidel C, Liu L, Tommasi S, Pfeifer GP (2003) Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. Histol Histopathol 18:665-677
5. Davis (1986) Basic methods in molecular biology. Elsevier, New York, pp 44-46
6. Frost GI, Mohapatra G, Wong TM, Csoka AB, Gray JW, Stern R (2000) HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. Oncogene 19:870-877
7. Graff JR, Herman JG, Myohanen S, Baylin SB, Vertino PM (1997) Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem 272:22322-22329
8. Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K, Heinrich MC, Rush J, Daibata M, Miyoshi I, Gilliland DG, Druker BJ, Polakiewicz RD (2007) A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia. Blood 110:323-333
9. Hesson LB, Cooper WN, Latif F (2007) Evaluation of the 3p21.3 tumour-suppressor gene cluster. Oncogene 26:7283-7301
10. Ji L, Minna JD, Roth JA (2005) 3p21.3 tumor suppressor cluster: prospects for translational applications. Future Oncol 1:79-92
11. Ji L, Nishizaki M, Gao B, Burbee D, Kondo M, Kamibayashi C, Xu K, Yen N, Atkinson EN, Fang B, Lerman MI, Roth JA, Minna JD (2002) Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res 62:2715-2720
12. Kholodnyuk ID, Kozireva S, Kost-Alimova M, Kashuba V, Klein G, Imreh S (2006) Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. Int J Cancer 119:99-107
13. Knudson AG Jr (1971) Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823
14. Kusy S, Potiron V, Zeng C, Franklin W, Brambilla E, Minna J, Drabkin HA, Roche J (2005) Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. Biochim Biophys Acta 1730:66-76
15. Lerman MI, Minna JD (2000) The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res 60:6116-6133
16. Li J, Wang F, Haraldson K, Protopopov A, Duh FM, Geil L, Kuzmin I, Minna JD, Stanbridge E, Braga E, Kashuba VI, Klein G, Lerman MI, Zabarovsky ER (2004) Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C. Cancer Res 64:6438-6443
17. Lokeshwar VB, Cerwinka WH, Isoyama T, Lokeshwar BL (2005a) HYAL1 hyaluronidase in prostate cancer: A tumor promoter and suppressor. Cancer Res 65:7782-7789
18. Lokeshwar VB, Cerwinka WH, Lokeshwar BL (2005b) HYAL1 hyaluronidase: A molecular determinant of bladder tumor growth and invasion. Cancer Res 65:2243-2250
19. Lokeshwar VB, Schroeder GL, Carey RI, Soloway MS, Iida N (2002) Regulation of hyaluronidase activity by alternative mRNA splicing. J Biol Chem 277:33654-33663
20. Melki JR, Vincent PC, Brown RD, Clark SJ (2000) Hypermethylation of E-cadherin in leukemia. Blood 95:3208-3213
21. Melki JR, Vincent PC, Clark SJ (1999) Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 59:3730-3740
22. Nair PN, McArdle L, Cornell J, Cohn SL, Stallings RL (2007) High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene. Cancer Genet Cytogenet 174:100-110
23. Oh JJ, Boctor B, Jimenez CA, Lopez RC, Razfar A, Slamon DJ (2005) Use of low-melting-point primers for bisulfite genomic sequencing: Analysis of the H37 lung cancer tumor suppressor gene promoter. Anal Biochem 343:347-349
24. Oh JJ, Razfar A, Delgado I, Reed RA, Malkina A, Boctor B, Slamon DJ (2006) 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. Cancer Res 66:3419-3427
25. Oh JJ, West AR, Fishbein MC, Slamon DJ (2002) A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3. Cancer Res 62:3207-3213
26. Ramaswamy S, Ross KN, Lander ES, Golub TR (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49-54
27. Shu Y, Rintala-Maki ND, Wall VE, Wang K, Goard CA, Langdon CE, Sutherland LC (2007) The apoptosis modulator and tumour suppressor protein RBM5 is a phosphoprotein. Cell Biochem Funct 25:643-653
28. Song JZ, Stirzaker C, Harrison J, Melki JR, Clark SJ (2002) Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells. Oncogene 21:1048-1061
29. Sutherland LC, Rintala-Maki ND, White RD, Morin CD (2005) RNA binding motif (RBM) proteins: A novel family of apoptosis modulators? J Cell Biochem 94:5-24
30. Tischoff I, Markwarth A, Witzigmann H, Uhlmann D, Hauss J, Mirmohammadsadegh A, Wittekind C, Hengge UR, Tannapfel A (2005) Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors. Int J Cancer 115:684-689
31. Uno F, Sasaki J, Nishizaki M, Carboni G, Xu K, Atkinson EN, Kondo M, Minna JD, Roth JA, Ji L (2004) Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells. Cancer Res 64:2969-2976
32. Yi HM, Ren CP, Peng D, Zhou L, Li H, Yao KT (2007) Expression, loss of heterozygosity, and methylation of GNAT1 gene in nasopharyngeal carcinoma. Ai Zheng 26:9-14
33. Zabarovsky ER, Lerman MI, Minna JD (2002) Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21:6915-6935
34. Zhang WJ, Koltun WA, Tilberg AF, Page MJ, Chorney MJ (2000) Absence of GNAI2 codon 179 oncogene mutations in inflammatory bowel disease. Inflamm Bowel Dis 6:103-106