Absence of GNAI2 codon 179 oncogene mutations in inflammatory bowel disease

Inflammatory Bowel Diseases

Volumn 6, Issue 2, 2000, Pages 103-106

  Zhang, Wen Jie ^a   Koltun, Walter A ^a   Tilberg, Anna F ^a   Page, Michael J ^a   Chorney, Michael J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

G protein; GNAI2; Inflammatory bowel disease; Polymerase chain reaction; RFLP

Indexed keywords

HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; ARTICLE; CHROMOSOME 3; COLON TUMOR; ENTERITIS; GENETICS; HUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; PEDIGREE; POLYMERASE CHAIN REACTION;

ADULT; CHROMOSOMES, HUMAN, PAIR 3; COLONIC NEOPLASMS; DNA MUTATIONAL ANALYSIS; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INFLAMMATORY BOWEL DISEASES; ONCOGENES; PEDIGREE; POLYMERASE CHAIN REACTION;

EID: 0034186476     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-200005000-00006     Document Type: Article

References (5)

1. Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. J Biol Chem 1988;263:6656-64.
2. Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature 1990;348: 125-32.
3. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabct P, Boulay G, Bradley A, Birnbaumer L. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice. Nat Genet 1995;10:143-50.
4. Homquist CE, Lu X, Rogers-Fani PM, Rudolph U, Shappell S, Birnbaumer L, Harriman GR. Gαi2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 1997;158:1068-77.
5. Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Bradley A, Bimbaumer L. Gi2 alpha protein deficiency: a model of inflammatory bowel disease. J Clin Immunol 1995;15(Suppl):101S-105S.