Gene expression profiling of post-mortem orbitofrontal cortex in violent suicide victims

International Journal of Neuropsychopharmacology

Volumn 11, Issue 2, 2008, Pages 217-228

  Thalmeier, Andreas ^a   Dickmann, Martin ^a   Giegling, Ina ^a   Schneider, Barbara ^b   Hartmann, Annette M ^a   Maurer, Konrad ^b   Schnabel, Axel ^b   Kauert, Gerold ^b   Möller, Hans Jürgen ^a   Rujescu, Dan ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Expression profiling; Gene expression; Orbitofrontal cortex; Post mortem; Suicide

Indexed keywords

CADHERIN; CADHERIN 12; CELL CYCLE PROTEIN; CELL DIVISION CYCLE ASSOCIATED 7 LIKE PROTEIN; EPIDERMAL GROWTH FACTOR CONTAINING FIBULIN LIKE EXTRACELLULAR MATRIX PROTEIN 1; MEGALENCEPHALIC LEUKOENCEPHALOPATHY WITH SUBCORTICAL CYSTS 1 PROTEIN; MESSENGER RNA; NERVE PROTEIN; PROTEIN S 100; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE RECEPTOR; PROTOCADHERIN 5; S100 CALCIUM BINDING PROTEIN A13; SCLEROPROTEIN; TRISTETRAPROLIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL 2 BETA;

ARTICLE; AUTOPSY; CELL ADHESION; CELL PROLIFERATION; CYTOGENETICS; GENE EXPRESSION PROFILING; HUMAN; NERVE CONDUCTION; ORBITAL CORTEX; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUICIDE;

ADULT; AGED; AGED, 80 AND OVER; AUTOPSY; CASE-CONTROL STUDIES; CLUSTER ANALYSIS; FEMALE; FRONTAL LOBE; GENE EXPRESSION PROFILING; HUMANS; MALE; MENTAL DISORDERS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUICIDE; VIOLENCE;

EID: 38949167737     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145707007894     Document Type: Article

References (50)

1. Arsenault-Lapierre G, Kim C, Turecki G (2004). Psychiatric diagnoses in 3275 suicides: a meta-analysis. BMC Psychiatry 4, 37.
2. Bahn S, Augood SJ, Ryan M, Standaert DG, Starkey M, Emson PC (2001). Gene expression profiling in the post-mortem human brain - no cause for dismay. Journal of Chemical Neuroanatomy 22, 79-94.
3. Balazic J, Marusic A (2005). The completed suicide as interplay of genes and environment. Forensic Science International 147 (Suppl.), S1-S3.
4. Barnes M, Freudenberg J, Thompson S, Aronow B, Pavlidis P (2005). Experimental comparison and cross-validation of the Affymetrix and Illumina gene expression analysis platforms. Nucleic Acids Reearch 33, 5914-5923.
5. Benjamini Y, Hochberg Y (2000). Controlling the false discovery rate/a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society B 57, 289-300.
6. Bertolote JM, Fleischmann A, De Leo D, Wasserman D (2004). Psychiatric diagnoses and suicide: revisiting the evidence. Crisis 25, 147-155.
7. Boor PK, de Groot K, Waisfisz Q, Kamphorst W, Oudejans CB, Powers JM, Pronk JC, Scheper GC, van der Knaap MS (2005). MLC1: a novel protein in distal astroglial processes. Journal of Neuropathology and Experimental Neurology 64, 412-419.
8. Brent DA, Mann JJ (2005). Family genetic studies, suicide, and suicidal behavior. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics 133, 13-24.
9. Carreira CM, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T (1998). S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. Journal of Biological Chemistry 273, 22224-22231.
10. Chan WY, Xia CL, Dong DC, Heizmann CW, Yew DT (2003). Differential expression of S100 proteins in the developing human hippocampus and temporal cortex. Microscopy Research and Technique 60, 600-613.
11. Chen K, Ou XM, Chen G, Choi SH, Shih JC (2005). R1, a novel repressor of the human monoamine oxidase A. Journal of Biological Chemistry 280, 11552-11559.
12. Chuaqui RF, Bonner RF, Best CJ, Gillespie JW, Flaig MJ, Hewitt SM, Phillips JL, Krizman DB, Tangrea MA, Ahram M, et al. (2002). Post-analysis follow-up and validation of microarray experiments. Nature Genetics 32 (Suppl.), 509-514.
13. Courtet P, Jollant F, Buresi C, Castelnau D, Mouthon D, Malafosse A (2005). The monoamine oxidase A gene may influence the means used in suicide attempts. Psychiatric Genetics 15, 189-193.
14. Craddock N, O'Donovan MC, Owen MJ (2005). The genetics of schizophrenia and bipolar disorder: dissecting psychosis. Journal of Medical Genetics 42, 193-204.
15. Dickinson T, Craumer W (2003). RNA profiling with bead-based array platforms: Sentrix arrays for focused gene expression studies across large sample sets. Genetic Engineering News 23, 1-4.
16. Du L, Faludi G, Palkovits M, Sotonyi P, Bakish D, Hrdina PD (2002). High activity-related allele of MAO-A gene associated with depressed suicide in males. Neuroreport 13, 1195-1198.
17. Dwivedi Y, Rizavi HS, Roberts RC, Conley RC, Tamminga CA, Pandey GN (2001). Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects. Journal of Neurochemistry 77, 916-928.
18. Dwivedi Y, Mondal AC, Rizavi HS, Conley RR (2005). Suicide brain is associated with decreased expression of neurotrophins. Biological Psychiatry 58, 315-324.
19. Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ (2006). Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochemical Journal 395, 483-491.
20. Gopalbhai K, Meloche S (1998). Repression of mitogen-activated protein kinases ERK1/ERK2 activity by a protein tyrosine phosphatase in rat fibroblasts transformed by upstream oncoproteins. Journal of Cell Physiology 174, 35-47.
21. Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, et al. (Gene Ontology Consortium) (2004). The Gene Ontology (GO) database and informatics resource. Nucleic Acids Research 32, D258-D261.
22. Hesselbrock V, Dick D, Hesselbrock M, Foroud T, Schuckit M, Edenberg H, Bucholz K, Kramer J, Reich T, Goate A, et al. (2004). The search for genetic risk factors associated with suicidal behavior. Alcoholism: Clinical and Experimental Research 28, 70S-76S.
23. Hynd MR, Lewohl JM, Scott HL, Dodd PR (2003). Biochemical and molecular studies using human autopsy brain tissue. Journal of Neurochemistry 85, 543-562.
24. Johnston NL, Cervenak J, Shore AD, Torrey EF, Yolken RH (1997). Multivariate analysis of RNA levels from postmortem human brains as measured by three different methods of RT-PCR. Stanley Neuropathology Consortium. Journal of Neuroscience Methods 77, 83-92.
25. Jollant F, Bellivier F, Leboyer M, Astruc B, Torres S, Verdier R, Castelnau D, Malafosse A, Courtet P (2005). Impaired decision making in suicide attempters. American Journal of Psychiatry 162, 304-310.
26. Kingsbury AE, Foster OJ, Nisbet AP, Cairns N, Bray L, Eve DJ, Lees AJ, Marsden CD (1995). Tissue pH as an indicator of mRNA preservation in human post-mortem brain. Brain Research. Molecular Brain Research 28, 311-318.
27. Konradi C (2005). Gene expression microarray studies in polygenic psychiatric disorders: applications and data analysis. Brain Research. Brain Research Reviews 50, 142-155.
28. Kuhn K, Baker SC, Chudin E, Lieu MH, Oeser S, Bennett H, Rigault P, Barker D, McDaniel TK, Chee MS (2004). A novel, high-performance random array platform for quantitative gene expression profiling. Genome Research 14, 2347-2356.
29. Kunugi H, Hashimoto R, Yoshida M, Tatsumi M, Kamijima K (2004). A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 129, 44-46.
30. Li JZ, Vawter MP, Walsh DM, Tomita H, Evans SJ, Choudary PV, Lopez JF, Avelar A, Shokoohi V, Chung T, et al. (2004). Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Human Molecular Genetics 13, 609-616.
31. Meyer J, Huberth A, Ortega G, Syagailo YV, Jatzke S, Mossner R, Strom TM, Ulzheimer-Teuber I, Stober G, Schmitt A, Lesch KP (2001). A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree. Molecular Psychiatry 6, 302-306.
32. Mimmack ML, Brooking J, Bahn S (2004). Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies. Biological Psychiatry 55, 337-345.
33. Mirnics K, Levitt P, Lewis D (2006). Critical appraisal of DNA microarrays in psychiatric genomics. Biological Psychiatry 15, 163-176.
34. Rozen S, Skaletsky H (2000). Primer3 on the WWW for general users and for biologist programmers. Methods in Molecular Biology 132, 365-386.
35. Rujescu D, Thalmeier A, Moller H, Bronisch T, Giegling I (2007). Molecular genetic findings in suicidal behavior: what is beyond the serotonergic system? Archives of Suicide Research 11, 17-40.
36. Schoenbaum G, Roesch MR, Stalnaker TA (2006). Orbitofrontal cortex, decision-making and drug addiction. Trends in Neuroscience 29, 116-124.
37. Schramm M, Falkai P, Tepest R, Schneider-Axmann T, Przkora R, Waha A, Pietsch T, Bonte W, Bayer TA (1999). Stability of RNA transcripts in post-mortem psychiatric brains. Journal of Neural Transmission 106, 329-335.
38. Sequeira A, Gwadry FG, Ffrench-Mullen JM, Canetti L, Gingras Y, Casero Jr. RA, Rouleau G, Benkelfat C, Turecki G (2006). Implication of SSAT by gene expression and genetic variation in suicide and major depression. Archives of General Psychiatry 63, 35-48.
39. Sibille E, Arango V, Galfalvy HC, Pavlidis P, Erraji-Benchekroun L, Ellis SP, Mann JJ (2004). Gene expression profiling of depression and suicide in human prefrontal cortex. Neuropsychopharmacology 29, 351-361.
40. Takeichi M, Abe K (2005). Synaptic contact dynamics controlled by cadherin and catenins. Trends in Cell Biology 15, 216-221.
41. Togashi H, Abe K, Mizoguchi A, Takaoka K, Chisaka O, Takeichi M (2002). Cadherin regulates dendritic spine morphogenesis. Neuron 35, 77-89.
42. Tomita H, Vawter MP, Walsh DM, Evans SJ, Choudary PV, Li J, Overman KM, Atz ME, Myers RM, Jones EG, et al. (2004). Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biological Psychiatry 55, 346-352.
43. Van Gelder RN, von Zastrow ME, Yool A, Dement WC, Barchas JD, Eberwine JH (1990). Amplified RNA synthesized from limited quantities of heterogeneous cDNA. Proceedings of the National Academy of Sciences USA 87, 1663-1667.
44. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biology 18, 3(7) research0034.
45. Vaquerizas JM, Conde L, Yankilevich P, Cabezon A, Minguez P, Diaz-Uriarte R, Al-Shahrour F, Herrero J, Dopazo J (2005). GEPAS, an experiment-oriented pipeline for the analysis of microarray gene expression data. Nucleic Acids Research 33, W616-W620.
46. Verma R, Mukerji M, Grover D, B-Rao C, Das SK, Kubendran S, Jain S, Brahmachari SK (2005). MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. Biological Psychiatry 58, 16-22.
47. Yasojima K, McGeer EG, McGeer PL (2001). High stability of mRNAs postmortem and protocols for their assessment by RT-PCR. Brain Research. Brain Res Protocols 8, 212-218.
48. Zhang B, Kirov S, Snoddy J (2005). WebGestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Research 33, W741-W748.
49. Zhang ZY (2005). Functional studies of protein tyrosine phosphatases with chemical approaches. Biochimica Biophysica Acta 1754, 100-107.
50. Zubenko GS, Maher BS, Hughes HB III, Zubenko WN, Scott SJ, Marazita ML (2004). Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 129, 47-54.