Dose-dependent beneficial hemodynamic effects of BAY 41-2272 in a canine model of acute pulmonary thromboembolism

European Journal of Pharmacology

Volumn 581, Issue 1-2, 2008, Pages 132-137

  Cau, Stefany B A ^a   Dias Junior, Carlos A ^a   Montenegro, Marcelo F ^a   de Nucci, Gilberto ^b   Antunes, Edson ^b   Tanus Santos, Jose E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Acute pulmonary embolism; BAY 41 2272; Pulmonary hypertension; Soluble guanylate cyclase

Indexed keywords

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ALCOHOL; CYCLIC GMP; DRUG VEHICLE; GUANYLATE CYCLASE; MICROSPHERE; SODIUM CHLORIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL GAS; ARTICLE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME IMMUNOASSAY; FEMALE; FLUOROMETRY; HYPOXEMIA; LUNG ARTERY PRESSURE; LUNG EMBOLISM; LUNG HEMODYNAMICS; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; VASODILATATION;

ACUTE DISEASE; ANIMALS; CYCLIC GMP; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUANYLATE CYCLASE; HEMODYNAMICS; LIPID PEROXIDES; MALE; PULMONARY EMBOLISM; PYRAZOLES; PYRIDINES; RESPIRATION;

EID: 38949121680     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.11.030     Document Type: Article

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