A role for matrix metalloproteinase-9 in the hemodynamic changes following acute pulmonary embolism

International Journal of Cardiology

Volumn 114, Issue 1, 2007, Pages 22-27

  Fortuna, Geisa M ^a   Figueiredo Lopes, Lívia ^b   Dias Junior, Carlos A C ^b   Gerlach, Raquel F ^b   Tanus Santos, Jose E ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Doxycyclin; Matrix metalloproteinases; Pulmonary embolism; Pulmonary hypertension

Indexed keywords

DOXYCYCLINE; GELATIN; GELATINASE B; MICROSPHERE; SODIUM CHLORIDE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HEART HEMODYNAMICS; HEART INDEX; LUNG ARTERY PRESSURE; LUNG EMBOLISM; LUNG VASCULAR RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; ZYMOGRAPHY;

ACUTE DISEASE; ANIMALS; DOGS; DOXYCYCLINE; FEMALE; HYPERTENSION, PULMONARY; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PULMONARY EMBOLISM;

EID: 33751234211     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2005.11.109     Document Type: Article

References (31)

1. Sadosty A.T., Boie E.T., and Stead L.G. Pulmonary embolism. Emerg Med Clin North Am 21 (2003) 363-384
2. Lualdi J.C., and Goldhaber S.Z. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J 130 (1995) 1276-1282
3. Smulders Y.M. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 48 (2000) 23-33
4. Tanus-Santos J.E., Gordo W.M., Udelsmann A., Cittadino M.H., and Moreno Jr. H. Nonselective endothelin-receptor antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs. Chest 118 (2000) 175-179
5. Tanus-Santos J.E., Gordo W.M., Udelsmann A., and Moreno Jr. H. The hemodynamic effects of endothelin receptor antagonism during a venous air infusion in dogs. Anesth Analg 90 (2000) 102-106
6. Tanus-Santos J.E., and Theodorakis M.J. Is there a place for inhaled nitric oxide in the therapy of acute pulmonary embolism?. Am J Respir Med 1 (2002) 167-176
7. Jeffery T.K., and Morrell N.W. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 45 (2002) 173-202
8. Frisdal E., Gest V., Vieillard-Baron A., et al. Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension. Eur Respir J 18 (2001) 838-845
9. Todorovich-Hunter L., Dodo H., Ye C., McCready L., Keeley F.W., and Rabinovitch M. Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Am Rev Respir Dis 146 (1992) 213-223
10. Fernandez-Patron C., Radomski M.W., and Davidge S.T. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 85 (1999) 906-911
11. Fernandez-Patron C., Stewart K.G., Zhang Y., Koivunen E., Radomski M.W., and Davidge S.T. Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. Circ Res 87 (2000) 670-676
12. Fernandez-Patron C., Zouki C., Whittal R., Chan J.S., Davidge S.T., and Filep J.G. Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]. FASEB J 15 (2001) 2230-2240
13. Battistini B. Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism. Can J Physiol Pharmacol 81 (2003) 555-569
14. Barnes P.J., and Liu S.F. Regulation of pulmonary vascular tone. Pharmacol Rev 47 (1995) 87-131
15. Palei A.C.T., Zaneti R.A.G., Fortuna G.M., Gerlach R.F., and Tanus-Santos J.E. Hemodynamic benefits of matrix metalloproteinase-9 inhibition by doxycycline during experimental acute pulmonary embolism. Angiology 5 (2005) 611-617
16. Dias-Junior C.A., Souza-Costa D.C., Zerbini T., Rocha J.B.T., Gerlach R.F., and Tanus-Santos J.E. Effect of sildenafil on pulmonary embolism-induced oxidative stress and pulmonary hypertension. Anesth Analg 101 (2005) 115-120
17. Dias-Junior C.A., Vieira T.F., Moreno Jr. H., Evora P.R., and Tanus-Santos J.E. Sildenafil selectively inhibits acute pulmonary embolism-induced pulmonary hypertension. Pulm Pharmacol Ther 18 (2005) 181-186
18. Souza-Silva A.R., Dias-Junior C.A., Uzuelli J.A., Moreno Jr. H., Evora P.R., and Tanus-Santos J.E. Hemodynamic effects of combined sildenafil and l-arginine during acute pulmonary embolism-induced pulmonary hypertension. Eur J Pharmacol 524 (2005) 126-131
19. Souza-Tarla C.D., Uzuelli J.A., Machado A.A., Gerlach R.F., and Tanus-Santos J.E. Methodological issues affecting the determination of plasma matrix metalloproteinase (MMP)-2 and MMP-9 activities. Clin Biochem 38 (2005) 410-414
20. Gerlach R.F., Uzuelli J.A., Souza-Tarla C.D., and Tanus-Santos J.E. Effect of anticoagulants on plasma matrix metalloproteinase (MMP)-2 and MMP-9 activities. Anal Biochem 344 (2005) 147-149
21. Eagleton M.J., Henke P.K., Luke C.E., et al. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism. J Vasc Surg 36 (2002) 581-588
22. Van den Steen P.E., Dubois B., Nelissen I., Rudd P.M., Dwek R.A., and Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 37 (2002) 375-536
23. Souza-Costa D.C., Zerbini T., Metzger I.F., Rocha J.B., Gerlach R.F., and Tanus-Santos J.E. l-Arginine attenuates acute pulmonary embolism-induced oxidative stress and pulmonary hypertension. Nitric Oxide 12 (2005) 9-14
24. Dikshit M., Srivastava R., and Srimal R.C. Role of free radicals in pulmonary thromboembolism in mice. Thromb Res 55 (1989) 549-557
25. Galis Z.S., and Khatri J.J. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res 90 (2002) 251-262
26. Souza-Costa D.C., Zerbini T., Palei A.C., Gerlach R.F., and Tanus-Santos J.E. l-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9. Chest 128 (2005) 3705-3710
27. Ayach B., Tsang J., Jeng A.Y., et al. Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism. Clin Sci (Lond) 103 (2002) 371S-375S
28. Behrendt C.E., and Ruiz R.B. Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy. Thromb Haemost 90 (2003) 734-737
29. Hao L., Du M., Lopez-Campistrous A., and Fernandez-Patron C. Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Circ Res 94 (2004) 68-76
30. Merklinger S.L., Jones P.L., Martinez E.C., and Rabinovitch M. Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 112 (2005) 423-431
31. Courtman D.W., Franco C.D., Meng Q., and Bendeck M.P. Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline. J Vasc Res 41 (2004) 157-165