Relationship between systemic nitric oxide metabolites and cyclic GMP in healthy male volunteers

Acta Physiologica

Volumn 188, Issue 2, 2006, Pages 123-127

  Metzger, I F ^a   Sertorio, J T C ^a   Tanus Santos, J E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cyclic GMP; Nitrate; Nitric oxide; Nitrite

Indexed keywords

CYCLIC GMP; NITRATE; NITRIC OXIDE; NITRITE; OZONE;

ADULT; ARTICLE; BLOOD SAMPLING; CHEMOLUMINESCENCE; CORRELATION ANALYSIS; DEMOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; VENOUS BLOOD;

ADULT; BIOLOGICAL MARKERS; BLOOD SPECIMEN COLLECTION; CYCLIC GMP; HUMANS; MALE; MIDDLE AGED; NITRATES; NITRIC OXIDE; NITRITES; REFERENCE VALUES;

EID: 33748367202     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2006.01612.x     Document Type: Article

References (32)

1. Barbosa, F., Sandrim, V.C., Jr, Uzuelli, J.A., Gerlach, R.F. & Tanus-Santos, J.E. 2006. eNOS genotype-dependent correlation between whole blood lead and plasma nitric oxide products concentrations. Nitric Oxide 14, 58-64.
2. Baylis, C. & Vallance, P. 1998. Measurement of nitrite and nitrate levels in plasma and urine - what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens 7, 59-62.
3. Castillo, L., Beaumier, L., Ajami, A.M. & Young, V.R. 1996. Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N]citrulline labeling. Proc Natl Acad Sci U S A 93, 11460-11465.
4. Cooke, J.P. & Dzau, V.J. 1997. Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48, 489-509.
5. Ellis, G., Adatia, I., Yazdanpanah, M. & Makela, S.K. 1998. Nitrite and nitrate analyses: a clinical biochemistry perspective. Clin Biochem 31, 195-220.
6. Gladwin, M.T., Crawford, J.H. & Patel, R.P. 2004. The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation. Free Radic Biol Med 36, 707-717.
7. Hibbs, J.B., Jr, Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R.L., Ward, J.H., Menlove, R.L., McMurry, M.P., Kushner, J.P., Sugimoto, T., Miyata, A., Kangawa, K. & Matsuo, H. 1992. Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. J Clin Invest 89, 867-877.
8. Hirata, Y., Ishii, M., Matsuoka, H., Sugimoto, T., Iizuka, M., Uchida, Y., Serizawa, T., Sato, H., Kohmoto, O., Mochizuki, T. & Samlowski, W.E. 1987. Plasma concentrations of alpha-human atrial natriuretic polypeptide and cyclic GMP in patients with heart disease. Am Heart J 113, 1463-1469.
9. Ignarro, L.J., Buga, G.M., Wood, K.S., Byrns, R.E. & Chaudhuri, G. 1987. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 84, 9265-9269.
10. Kelm, M., Preik-Steinhoff, H., Preik, M. & Strauer, B.E. 1999. Serum nitrite sensitively reflects endothelial NO formation in human forearm vasculature: evidence for biochemical assessment of the endothelial L-arginine-NO pathway. Cardiovasc Res 41, 765-772.
11. Kielstein, J.T., Impraim, B., Simmel, S., Bode-Boger, S.M., Tsikas, D., Frolich, J.C., Hoeper, M.M., Haller, H. & Fliser, D. 2004. Cardiovascular effects of systemic nitric oxide synthase inhibition with asymmetrical dimethylarginine in humans. Circulation 109, 172-177.
12. Kim, H.P., Ryter, S.W. & Choi, A.M. 2006. Co as a cellular signaling molecule. Annu Rev Pharmacol Toxicol 46, 411-449.
13. Kleinbongard, P., Dejam, A., Lauer, T., Rassaf, T., Schindler, A., Picker, O., Scheeren, T., Godecke, A., Schrader, J., Schulz, R., Heusch, G., Schaub, G.A., Bryan, N.S., Feelisch, M. & Kelm, M. 2003. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 35, 790-796.
14. Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R.B., Scharf, R.E., Willers, R., Schechter, A.N., Feelisch, M. & Kelm, M. 2006. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med 40, 295-302.
15. Lauer, T., Preik, M., Rassaf, T., Strauer, B.E., Deussen, A., Feelisch, M. & Kelm, M. 2001. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci U S A 98, 12814-12819.
16. Lundberg, J.O. 2006. Nitric oxide metabolites and cardiovascular disease markers, mediators, or both? J Am Coll Cardiol 47, 580-581.
17. Lundberg, J.O. & Govoni, M. 2004. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 37, 395-400.
18. Lundberg, J.O. & Weitzberg, E. 2005. NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol 25, 915-922.
19. Lundberg, J.O., Weitzberg, E., Cole, J.A. & Benjamin, N. 2004. Nitrate, bacteria and human health. Nat Rev Microbiol 2, 593-602.
20. Metzger, I.F., Souza-Costa, D.C., Marroni, A.S., Nagassaki, S., Desta, Z., Flockhart, D.A. & Tanus-Santos, J.E. 2005. Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men. Pharmacogenet Genomics 15, 565-570.
21. Modin, A., Bjorne, H., Herulf, M., Alving, K., Weitzberg, E. & Lundberg, J.O. 2001. Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation. Acta Physiol Scand 171, 9-16.
22. Moshage, H., Kok, B., Huizenga, J.R. & Jansen, P.L. 1995. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 41, 892-896.
23. Nagassaki, S., Metzger, I.F., Souza-Costa, D.C., Marroni, A.S., Uzuelli, J.A. & Tanus-Santos, J.E. 2005. eNOS genotype is without effect on circulating nitrite/nitrate level in healthy male population. Thromb Res 115, 375-379.
24. Nagassaki, S., Sertorio, J.T.C., Metzger, I.F., Bem, A.F., Rocha, J.B.T. & Tanus-Santos, J.E. 2006. eNOS gene T-786C polymorphism modulates atorvastatin-induced increase in blood nitrite. Free Radic Biol Med. Epub ahead of print doi: 10.1016/j.freeradbiomed.2006.04.026.
25. Palmer, R.M., Ferrige, A.G. & Moncada, S. 1987. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526.
26. Rhodes, P., Leone, A.M., Francis, P.L., Struthers, A.D., Moncada, S. & Rhodes, P.M. 1995. The L-arginine:nitric oxide pathway is the major source of plasma nitrite in fasted humans. Biochem Biophys Res Commun 209, 590-596.
27. Rosselli, M., Imthurn, B., Keller, P.J., Jackson, E.K. & Dubey, R.K. 1995. Circulating nitric oxide (nitrite/nitrate) levels in postmenopausal women substituted with 17 beta-estradiol and norethisterone acetate. A two-year follow-up study. Hypertension 25, 848-853.
28. Souza-Silva, A.R., Dias-Junior, C.A., Uzuelli, J.A., Moreno, H., Jr, Evora, P.R. & Tanus-Santos, J.E. 2005. Hemodynamic effects of combined sildenafil and l-arginine during acute pulmonary embolism-induced pulmonary hypertension. Eur J Pharmacol 524, 126-131.
29. Tanus-Santos, J.E., Gordo, W.M., Cittadino, M. & Moreno, H., Jr 2000. Plasma cGMP levels in air embolism-induced acute lung injury. J Crit Care 15, 137-141.
30. Waldman, S.A. & Murad, F. 1987. Cyclic GMP synthesis and function. Pharmacol Rev 39, 163-196.
31. Wang, X.L., Mahaney, M.C., Sim, A.S., Wang, J., Blangero, J., Almasy, L., Badenhop, R.B. & Wilcken, D.E. 1997. Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol 17, 3147-3153.
32. Yang, B.K., Vivas, E.X., Reiter, C.D. & Gladwin, M.T. 2003. Methodologies for the sensitive and specific measurement of S-nitrosothiols, iron-nitrosyls, and nitrite in biological samples. Free Radic Res 37, 1-10.