Hemodynamic benefits of matrix metalloproteinase-9 inhibition by doxycycline during experimental acute pulmonary embolism

Angiology

Volumn 56, Issue 5, 2005, Pages 611-617

  Palei, Ana C T ^a   Zaneti, Rafael A G ^a   Fortuna, Geisa M ^b   Gerlach, Raquel F ^a   Tanus Santos, Jose Eduardo ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE A; GELATINASE B;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MODEL; HEART RATE; LUNG EMBOLISM; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; DEXTRANS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; HEMODYNAMIC PROCESSES; INDICATORS AND REAGENTS; MALE; MATRIX METALLOPROTEINASE 9; PULMONARY EMBOLISM; RATS; RATS, WISTAR;

EID: 25644445991     PISSN: 00033197     EISSN: None     Source Type: Journal    
DOI: 10.1177/000331970505600513     Document Type: Article

References (24)

1. Sadosty AT, Boie ET, Stead LG: Pulmonary embolism. Emerg Med Clin North Am 21:363-384, 2003.
2. Lualdi JC, Goldhaber SZ: Right ventricular dysfunction after acute pulmonary embolism: Pathophysiologic factors, detection, and therapeutic implications. Am Heart J 130:1276-1282, 1995.
3. Smulders YM: Pathophysiology and treatment of hemodynamic instability in acute pulmonary embolism: The pivotal role of pulmonary vasoconstriction. Cardiovasc Res 48:23-33, 2000.
4. Tanus-Santos JE, Gordo WM, Udelsmann A, et al: Nonselective endothelin-receptor antagonism attenuates hemodynamic changes after massive pulmonary air embolism in dogs. Chest 118:175-179, 2000.
5. Tanus-Santos JE, Gordo WM, Udelsmann A, et al: The hemodynamic effects of endothelin receptor antagonism during a venous air infusion in dogs. Anesth Analg 90:102-106, 2000.
6. Tanus-Santos JE, Theodorakis MJ: Is there a place for inhaled nitric oxide in the therapy of acute pulmonary embolism? Am J Respir Med 1:167-176, 2002.
7. Jeffery TK, Morrell NW: Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 45:173-202, 2002.
8. Frisdal E, Gest V, Vieillard-Baron A, et al: Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension. Eur Respir J 18:838-845, 2001.
9. Todorovich-Hunter L, Dodo H, Ye C, et al: Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Am Rev Respir Dis 146:213-223, 1992.
10. Fernandez-Patron C, Radomski MW, Davidge ST: Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 85:906-911, 1999.
11. Fernandez-Patron C, Stewart KG, Zhang Y, et al: Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction. Circ Res 87:670-676, 2000.
12. Fernandez-Patron C, Zouki C, Whittal R, et al: Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]. Faseb J 15:2230-2240, 2001.
13. Battistini B: Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism. Can J Physiol Pharmacol 81:555-569, 2003.
14. Barnes PJ, Liu SF: Regulation of pulmonary vascular tone. Pharmacol Rev 47:87-131, 1995.
15. Weimann J, Zink W, Gebhard MM, et al: Effects of oxygen and nitric oxide inhalation in a porcine model of recurrent microembolism. Acta Anaesthesiol Scand 44:1109-1115, 2000.
16. Bendeck MP, Conte M, Zhang M, et al: Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. Am J Pathol 160:1089-1095, 2002.
17. Kleiner DE, Stetler-Stevenson WG: Quantitative zymography: Detection of picogram quantities of gelatinases. Anal Biochem 218:325-329, 1994.
18. Ohbayashi H: Matrix metalloproteinases in lung diseases. Curr Protein Pept Sci 3:409-421, 2002.
19. Eagleton MJ, Henke PK, Luke CE, et al: Inflammation and intimal hyperplasia associated with experimental pulmonary embolism. J Vasc Surg 36:581-588, 2002.
20. Van den Steen PE, Dubois B, Nelissen I, et al: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 37:375-536, 2002.
21. Galis ZS, Khatri JJ: Matrix metalloproteinases in vascular remodeling and atherogenesis: The good, the bad, and the ugly. Circ Res 90:251-262, 2002.
22. Grote K, Flach I, Luchtefeld M, et al: Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD(P)H oxidase-derived reactive oxygen species. Circ Res 92:e80-86, 2003.
23. Ayach B, Tsang J, Jeng AY, et al: Effects of a selective endothelin A receptor antagonist, ABT-627, in healthy normotensive anaesthetized rats developing acute pulmonary air embolism. Clin Sci (Lond) 103:371S-375S, 2002.
24. Behrendt CE, Ruiz RB: Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy. Thromb Haemost 90:734-737, 2003.