The synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells

Cancer Investigation

Volumn 26, Issue 2, 2008, Pages 118-127

  Hughes, David T ^a,b   Martel, Peter M ^a,b   Kinlaw, William B ^a,b   Eisenberg, Burton L ^a,b  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

CDDO; Fatty acid synthase; Lipogenic; Liposarcoma; Spot 14; Triterpenoid

Indexed keywords

2 CYANO 3,12 DIOXOOLEAN 1,9 DIEN 28 OIC ACID IMIDAZOLIDE; ANTINEOPLASTIC AGENT; CERULENIN; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; LONG CHAIN FATTY ACID; TRITERPENOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FATTY ACID TRANSPORT; HUMAN; HUMAN CELL; LIPOGENESIS; LIPOSARCOMA; MITOSIS INHIBITION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SARCOMA CELL;

ADIPOCYTES; ANTIGENS, CD95; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CERULENIN; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FATTY ACID SYNTHESIS INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; GLYCEROLPHOSPHATE DEHYDROGENASE; HUMANS; IMIDAZOLES; LIPOSARCOMA; OLEANOLIC ACID; PALMITIC ACID; TUMOR CELLS, CULTURED;

EID: 38949090320     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900701522612     Document Type: Article

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