Conformational movement of F251 contributes to the molecular mechanism of constitutive activation in the C5a receptor

Chemical Biology and Drug Design

Volumn 71, Issue 3, 2008, Pages 197-204

  Sen, Saurabh ^a,b   Baranski, Thomas J ^a   Nikiforovich, Gregory V ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Complement factor 5a receptor; Constitutive activity; G protein coupled receptors; Molecular modeling; Mutant receptors

Indexed keywords

COMPLEMENT COMPONENT C5A RECEPTOR; F 251 PROTEIN; G PROTEIN COUPLED RECEPTOR; MUTANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; CASE REPORT; CONFORMATIONAL TRANSITION; ELECTROPHORESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; MOLECULAR MECHANICS; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DATA BANK; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; WILD TYPE;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTOR, ANAPHYLATOXIN C5A;

EID: 38849210020     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00630.x     Document Type: Article

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