Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor

Chemistry and Biodiversity

Volumn 5, Issue 1, 2008, Pages 140-152

  Rivara, Mirko ^a   Vacondio, Federica ^a   Silva, Claudia ^a   Zuliani, Valentina ^a   Fantini, Marco ^a   Bordi, Fabrizio ^a   Plazzi, Pier Vincenzo ^a   Bertoni, Simona ^b   Ballabeni, Vigilio ^b   Flammini, Lisa ^b   Barocelli, Elisabetta ^b   Mor, Marco ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b Parco Area delle Scienze 157A   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 ETHYLMETHYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; 1 METHYLHEPTYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; 1,1 DIMETHYLETHYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; 2 [[2 (1H IMIDAZOL 4 YL)ETHYL]SULFANYL] 1,3 BENZOTHIAZOLE; ALKYL GROUP; ALPHA METHYLHISTAMINE; BOVINE SERUM ALBUMIN; BUTYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; CARBAMIC ACID DERIVATIVE; CARBOXYLIC ACID; CYCLOHEXYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; ESTERASE; ETHYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; HEXYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; HISTAMINE H3 RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; LIGAND; LIVER ENZYME; OCTYL 4 [2 [(1,3 BENZOTHIAZOL 2 YL)SULFANYL]ETHYL] 1H IMIDAZOLE 1 CARBOXYLATE; ROS 203; THIOPERAMIDE; TRITIUM; UNCLASSIFIED DRUG; URETHAN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG STABILITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; EX VIVO STUDY; FEMALE; HUMAN; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR RECOGNITION; NONHUMAN; RAT; STEREOSPECIFICITY;

ANIMALS; BENZOTHIAZOLES; CARBOXYLIC ACIDS; CATALYSIS; CATTLE; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; ESTERASES; HISTAMINE H3 ANTAGONISTS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMIDAZOLES; INJECTIONS, INTRAVENOUS; LIVER; MOLECULAR STRUCTURE; RATS; RECEPTORS, HISTAMINE H3; SERUM ALBUMIN, BOVINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

BOVINAE; RATTUS; SUS;

EID: 38849194032     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200890004     Document Type: Article

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