Cyclohexyloxycarbonyl based orthogonal solid phase peptide synthesis in Boc chemistry

Tetrahedron

Volumn 54, Issue 24, 1998, Pages 6757-6766

  Mezo, Gábor ^a   Mihala, Nikolett ^a   Kóczán, György ^a   Hudecz, Ferenc ^a  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; GLYCOPROTEIN; HEXAPEPTIDE; PEPTIDE; VIRUS PROTEIN;

ARTICLE; CHEMICAL REACTION; HERPES SIMPLEX VIRUS 1; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STABILITY;

EID: 0032507987     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)00360-3     Document Type: Article

References (22)

1. 1. Abbreviations used in this paper for amino acids and for the designations of peptides follow the rules of the IUPAC-IUB Comission of Biochemical Nomenclature in European J. Biochem., 1984, 138, 9-37 and J. Biol. Chem., 1989, 264, 633-673. The following additional abbreviations are used: Boc, tert-butyloxycarbonyl; BHA, benzhydrylamine resin; Bzl, benzyl; cHex, cyclohexyl; Choc, cyclohexyloxycarbonyl; CIZ, 2-chloro-benzyloxycarbonyl; DCC, N,N′-dicyclohexyl-carbodiimide; DCM, dichloromethane; DIEA, N,N′-diisopropylethylamine; DMF, N,N-dimethylformamide; FAB-MS, fast atom bombardment mass spectrometry; Fm, 9-fluorenylmethyl; Fmoc, 9-fluorenylmethoxycarbonyl; HF, hydrogen-fluoride; HOBt, 1-hydroxy-benzotriazole; HSV, Herpes simplex virus; ODS, octadecyl silane; PAM, 4-oxymethylphenylacetamidomethyl; PyBOP, (benzotriazolyl)-N-oxypyrrolidinephosphonium hexafluorophosphate; RP-HPLC, reverse phase high-performance liquid chromatography; TFA, trifluoracetic add; tlc., thin-layer chromatography; TMSOTf, trimethylsilyl trifluoromethanesulphonate; Z, benzyloxycarbonyl. Amino acid symbols denote L-configuration unless indicated otherwise.
2. 1. Abbreviations used in this paper for amino acids and for the designations of peptides follow the rules of the IUPAC-IUB Comission of Biochemical Nomenclature in European J. Biochem., 1984, 138, 9-37 and J. Biol. Chem., 1989, 264, 633-673. The following additional abbreviations are used: Boc, tert-butyloxycarbonyl; BHA, benzhydrylamine resin; Bzl, benzyl; cHex, cyclohexyl; Choc, cyclohexyloxycarbonyl; CIZ, 2-chloro-benzyloxycarbonyl; DCC, N,N′-dicyclohexyl-carbodiimide; DCM, dichloromethane; DIEA, N,N′-diisopropylethylamine; DMF, N,N-dimethylformamide; FAB-MS, fast atom bombardment mass spectrometry; Fm, 9-fluorenylmethyl; Fmoc, 9-fluorenylmethoxycarbonyl; HF, hydrogen-fluoride; HOBt, 1-hydroxy-benzotriazole; HSV, Herpes simplex virus; ODS, octadecyl silane; PAM, 4-oxymethylphenylacetamidomethyl; PyBOP, (benzotriazolyl)-N-oxypyrrolidinephosphonium hexafluorophosphate; RP-HPLC, reverse phase high-performance liquid chromatography; TFA, trifluoracetic add; tlc., thin-layer chromatography; TMSOTf, trimethylsilyl trifluoromethanesulphonate; Z, benzyloxycarbonyl. Amino acid symbols denote L-configuration unless indicated otherwise.
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