Acute β-blockade increases muscle sympathetic activity and modifies its frequency distribution

Circulation

Volumn 110, Issue 18, 2004, Pages 2786-2791

  Cogliati, Chiara ^a   Colombo, Simona ^c   Ruscone, Tomaso Gnecchi ^c   Gruosso, Domenico ^d   Porta, Alberto ^b   Montano, Nicola ^a   Malliani, Alberto ^a   Furlan, Raffaello ^a,c  

^a UNIVERSITY OF MILAN   (Italy)

^b DISP LITA Vialba   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Adrenergic antagonists; Baroreceptors; Nervous system, autonomic; Nervous system, sympathetic

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOLAMINE; PLACEBO;

ADULT; ARTERIAL PRESSURE; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; BREATHING; CATECHOLAMINE BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG MECHANISM; ELECTROCARDIOGRAM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MUSCLE INNERVATION; MUSCLE TONE; NORMAL HUMAN; OSCILLATION; POSTGANGLIONIC NERVE; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RR INTERVAL; SYMPATHETIC TONE; VASOCONSTRICTION;

ACTION POTENTIALS; ADRENERGIC BETA-ANTAGONISTS; ADULT; ATENOLOL; BAROREFLEX; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; EPINEPHRINE; FEMALE; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MUSCLE, SKELETAL; NOREPINEPHRINE; PERONEAL NERVE; RESPIRATION; SYMPATHETIC FIBERS, POSTGANGLIONIC; VASOCONSTRICTION; VASOMOTOR SYSTEM;

EID: 8144224969     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000146335.69413.F9     Document Type: Article

References (39)

1. Schwartz P, La Rovere M, Vanoli E. Autonomic nervous system and sudden cardiac death: experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85:177-191.
2. Beta Blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction, I: mortality result. JAMA. 1982;247:1707-1714.
3. Pitt B. The role of beta-adrenergic blocking agents in preventing sudden cardiac death. Circulation. 1992;85(suppl I):I-107-I-111.
4. Malliani A, Schwartz P, Zanchetti A. Neural mechanisms in life threatening arrhythmias. Am Heart J. 1980;200:705-715.
5. Pagani M, Lombardi F, Guzzetti S, et al. Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ Res. 1986;59:178-193.
6. Malliani A, Pagani M, Lombardi F, et al. Cardiovascular neural regulation explored in the frequency domain. Circulation. 1991;84:482-492.
7. Montano N, Gnecchi Ruscone T, et al. Power spectrum analysis of heart rate variability to assess the changes in sympatho-vagal balance during graded orthostatic tilt. Circulation. 1994;90:1826-1831.
8. Pomeranz B, Macaulay R, Caudill M, et al. Assessment of autonomic function in humans by heart rate spectral analysis. Am J Physiol. 1985;248:H151-H153.
9. Hayano J, Sakakibara Y, Yamada A, et al. Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am J Cardiol. 1991;67:199-204.
10. Taylor J, Christopher W, Halliwill J, et al. Sympathetic restraint of respiratory sinus arrhythmia: implications for vagal-cardiac tone assessment in humans. Am J Physiol. 2001;280:H2804-H2814.
11. Sundlof G, Wallin B, Stromgren E, et al. Acute effects of metoprolol on muscle sympathetic activity in hypertensive humans. Hypertension. 1983;5:749-756.
12. Tank J, Diedrich A, Schoeder C. et al. Limited effect of systemic beta-blockade on sympathetic outflow. Hypertension. 2001;38:1377-1381.
13. Jacobsen T, Converse R, Victor R. Contrasting effects of propranolol on sympathetic nerve activity and vascular resistance during orthostatic stress. Circulation. 1992;85:1072-1076.
14. Pagani M, Montano N, Porta A, et al. Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation. 1997;95:1441-1448.
15. Furlan R, Porta A, Costa F, et al. Oscillatory patterns in sympathetic neural discharge and cardiovascular variables during orthostatic stimulus. Circulation. 2000;101:886-892.
16. Montano N, Cogliati C, Porta A, et al. Central vagotonic effects of atropine modulate spectral oscillations of sympathetic nerve activity. Circulation. 1998;14:1394-1399.
17. Van de Borne P, Montano N, Pagani M, et al. Absence of low frequency variability of sympathetic nerve activity in severe heart failure. Circulation. 1997;95:1449-1454.
18. Narkiewicz K, Montano N, Cogliati C, et al. Altered cardiovascular variability in obstructive sleep apnea. Circulation. 1998;98:1071-1077.
19. Furlan R, Magatelli R, Palazzolo L, et al. Orthostatic intolerance: different abnormalities in the neural sympathetic response to a gravitational stimulus. Auton Neurosci. 2001;90:83-88.
20. Wallin B. Intraneural recording and autonomic function in man. In: Bannister R, ed. Autonomic Failure. London, UK: Oxford University Press; 1983:36-51.
21. Mark A, Victor R, Nerhed C, et al. Microneurographic study of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res. 1985;57:461-469.
22. Rea R, Biaggioni I, Robertson R, et al. Reflex control of sympathetic nerve activity in dopamine-beta-hydroxylase deficiency. Hypertension. 1990;15:107-112.
23. Baselli G, Cerutti S, Civardi S, et al. Spectral and cross-spectral analysis of heart rate and arterial blood pressure variability signals. Comput Biomed Res. 1986;19:520-534.
24. Pagani M, Somers V, Furlan R, et al. Changes in autonomic regulation induced by physical training in mild hypertension. Hypertension. 1988;12:600-610.
25. Wadworth A, Murdoch D, Brogden R. Atenolol: a reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders. Drugs. 1991;42:468-510.
26. Tung C-S, Goldberg M, Hollister A, et al. Both alpha- and beta-adrenoceptors contribute to the central depressor effect of catecholamines. Brain Res. 1988;456:64-70.
27. Day M, Poyser R, Sempik J. Effects on blood pressure of noradrenaline and isoprenaline administered into the third ventricle of the brain of anesthetized and conscious cats. J Auton Pharmacol. 1980;1:37-43.
28. Azevedo E, Kubo T, Mak S, et al. Nonselective versus selective beta-adrenergic receptor blockade in congestive heart failure: differential effects on sympathetic activity. Circulation. 2001;104:2194-2199.
29. Van de Borne P, Montano N, Narkiewicz K, et al. Importance of ventilation in modulating interaction between sympathetic drive and cardiovascular variability. Am J Physiol. 2001;280:H722-H729.
30. Guyenet P. Neural structures that mediate sympathoexcitation during hypoxia. Respir Physiol. 2000;121:147-162.
31. Eckberg D, Nerhed C, Wallin B. Respiratory modulation of muscle sympathetic and vagal cardiac outflow in man. J Physiol. 1985;365:181-196.
32. Dempsey J, Sheel A, St. Croix C, et al. Respiratory influences on sympathetic vasomotor outflow in humans. Respir Physiol Neurobiol. 2002;130:3-20.
33. Stauss H, Anderson E, Haynes W, et al. Frequency response characteristics of sympathetically mediated vasomotor waves in humans. Am J Physiol. 1998;274:H1277-H1283.
34. Bernards L, Hayoz D, Wenzel R, et al. Synchronous and baroreceptor-sensitive oscillations in skin microcirculation: evidence for central autonomic control. Am J Physiol. 1997;273:H1867-H1878.
35. Cook J, Bigger J, Kleiger R, et al. Effect of atenolol and diltiazem on heart period variability in normal persons. J Am Coll Cardiol. 1991;17:480-484.
36. Bittiner S, Smith S. Beta-adrenoceptor antagonists increases sinus arrhythmia and vagotonic effect. Br J Clin Pharmacol. 1986;1986:691-695.
37. Vaile I, Fletcher J, Al-Ani M, et al. Use of opposing reflex stimuli and heart rate variability to examine the effects of lipophilic and hydrophilic beta-blockers on human cardiac vagal control. Clin Sci. 1999;1997:585-593.
38. Pitzalis M, Mastropasqua F, Massari F, et al. Beta-blocker effects on respiratory sinus arrhythmia and baro-reflex gain in normal subjects. Chest. 1998;114:185-191.
39. Pagani M, Malliani A. Interpreting oscillations of muscle sympathetic nerve activity and heart rate variability. J Hypertens. 2000;18:1709-1719.