Nuclear loss of DNA repair Ku proteins and c-myc expression in apoptosis of cerulein-stimulated pancreatic acinar cells

Inflammopharmacology

Volumn 15, Issue 6, 2007, Pages 282-287

  Yu, J H ^a   Kim, K H ^a   Kim, H ^b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

Author keywords

Apoptosis; C myc; Cerulein; DNA repair Ku proteins; Pancreatic acinar cells

Indexed keywords

CERULETIDE; KU ANTIGEN; MYC PROTEIN;

ACINAR CELL; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; DNA REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; BLOTTING, WESTERN; CAERULEIN; CELL COUNT; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; DNA REPAIR; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GASTROINTESTINAL AGENTS; GENE EXPRESSION; GENES, MYC; PANCREAS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 38849136488     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-007-1588-y     Document Type: Article

References (49)

1. Aho, H. J., Nevalainen, T. J., Havia, V. T. (1982) Human acute pancreatitis: A light and electron microscopic study. Acta Pathol. Microbiol. Immunol. Scan. [A] 90, 367-373.
2. Ajmani, A. K., Satoh, M., Reap, E. et al. (1995) Absence of autoantigen ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. J. Exp. Med. 181, 2049-2058.
3. Albihn, A., Loven, J., Ohlsson, J. et al. (2006) C-Myc-dependnet etoposide-induced apoptosis involves activation of bax and caspases, and PKCdelta signaling. J. Cell. Biochem. 98, 1597-1614.
4. Arrington, E. D., Caldwell, M. C., Kumaravel, T. S. et al. (2000) Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Rad. Biol. Med. 29, 1166-1176.
5. Beckman, K. B., Ames, B. N. (1998) The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
6. 4 induced increased in vascular leakage by PMN-leukocytes. Agents Actions 11, 63-73.
7. Bliss, T. M., Lane, D. P. (1997) Ku selectively transfers between DNA molecules with homologious ends. J. Biol. Chem. 272, 5765-5773.
8. Bradford, M. M. (1993) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
9. Carson, D. A., Ribeiro, J. M. (1993) Apoptosis and disease. Lancet 341, 1251-1254.
10. Desbiens, K. M., Deschesnes, R. G., Labrie, M. M. et al. (1999) Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biochem. 144, 891-910.
11. Endoh D, Okui T, Kon Y. et al. (2001) Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku protein G22p1 (Ku70) and Xrcc5(Ku80) in rat fibroblasts. Radiat. Res. 155, 320-327.
12. Featherstone, C., Jackson, S. P. (1999) Ku, a DNA repair protein with multiple cellular functions? Mutation Research 434, 3-15.
13. Fujimura, M., Morita-Fujimura, Y., Kawase, M. et al. (1999a) Early decrease of apurinic/apyrimidinic endonuclease expression following transient focal cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19, 495-501.
14. Fujimura, M., Morita-Fujimura, Y., Sugawara, T. et al. (1999b) Early decrease of XRCC1, a DNA base excision repair protein, may contribute to DNA fragmentation after transient focal cerebral ischemia in mice. Stroke 30, 2456-2462.
15. nd ed. In: Go, V. W., DiMagno, E. P., Gardner, J. D. et al., editors. The pancreas: Biology, pathobiology, and disease. New York: Raven Press, 501-526.
16. Guice, K. S., Oldham, K. T., Caty, M. G. et al. (1989) Neutrophil-dependent, oxygen-radical mediated lung injury associated with acute pancreatitis. Ann. Surg. 210, 740-747.
17. Gukovskaya, A. S., Perkins, P., Zaninovic, V. et al. (1996) Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 110, 875-884.
18. Gukovskaya, A. S., Gukovsky, I., Zaninovic, V. et al. (1997) Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-α: Role in regulating cell death and pancreatitis. J. Clin. Invest. 100, 1853-1862.
19. Guyan PM, Udern S, Braganza JM. Hightened free radical activity in pancreatitis. Free Rad Biol Med 8:347-354, 1990.
20. Hu, J. J., Dubin, N., Kurland, D. et al. (1995) The effects of hydrogen peroxide on DNA repair activities. Mutat. Res. 336, 193-201.
21. Jensen, R. T., Wank, S. A., Rowley, W. H. et al. (1989) Interaction of CCK with pancreatic acinar cells. Trends Pharmacol. Sci. 10, 418-423.
22. Kaiser, A. M., Saluja, A. K., Sengupa, A. et al. (1995a) Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am. J. Physiol. 269, C1295-1304.
23. Kaiser, A. M., Saluja, A. K., Sengupta, A. et al. (1995b) Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am. J. Physiol. 269, C1295-C1304.
24. Kaiser, A. M., Saluja, A. K., Lu, L. et al. (1996) Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, a severity of acute pancreatitis. Am. J. Physiol. 271, C982-993.
25. Kerr, J. F. R., Wyllie, A. H., Currie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer 26, 239-245.
26. Kimura, K., Shimosegawa, T., Sasano, H. et al. (1998) Endogeous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats. Gastroenterology 114, 372-381.
27. Koike, M., Awaji, T., Kataoka, M. et al. (1999a) Differential subcellular localization of DNA-dependent protein kinase components Ku and DNA-PKcs during mitosis. J. Cell Sci. 112, 4031-4039.
28. Koike, M., Ikuta, T., Miyasaka, T. et al. (1999b) Ku80 can translocate to the nucleus independent of the translocation of Ku70 using its own nuclear localization signal. Oncogene 18, 7495-7505
29. Koike, M., Shiomi, T., Koike, A. (1999c) Dimerization and nuclear localization of Ku proteins. Exp. Cell Res. 250, 401-413.
30. Li, G., Nelsen, C., Hendrickson, E. A.(2002) Ku86 is essential in human somatic cells. Proc. Natl. Acad. Sci. USA 99, 832-837.
31. Li, J. J., Westergaard, C., Ghosh, P. et al. (1997) Inhibitors of both nuclear factor-kappa B and activator protein-1 activation block the neoplastic transformation response. Cancer Res. 57, 3569-3576.
32. McConnell, K. R., Dynan, W. S., Hardin, J. A.(1997) The DNA-dependent protein kinase catalytic subunit (p460) is cleaved during Fas-mediated apoptosis in Jarkat cells. J. Immunol. 158, 2083-2089.
33. Morio, T., Hanissian, S. H., Bacharier, L. B. et al. (1999) Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb. Immunity 11, 339-348.
34. Nussenzweig, A., Sokol, K., Burgman, P. et al. (1997) Hypersensitivity of Ku80 - deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc. Natl. Acad. Sci. USA 94, 13588-13593.
35. Petrone, W. F., English, D. K., Wong, K. (1980) Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma. Proc. Natl. Acad. Sci. USA 77, 159-1163.
36. Ramadani, M., Yang, Y., Gansauge, F. et al. (2001) Overexpression of caspase-1 (interleukin-1 beta converting enzyme) in chronic pancreatitis and its participation in apoptosis and proliferation. Pancreas 22, 383-387.
37. Sandoval, D., Gukovskaya, A., Reavey, P. et al. (1996) The role of neutrophils and platelet-activating factor in mediating experiemental pancreatitis. Gastroenterology 111, 1081-1091.
38. Sanfey, H., Bulkeley, G. B., Cameron, J. L. (1985) The pathogenesis of acute pancreatitis: the source and role of oxygen-derived free radicals in three different experimental models. Ann. Surg. 201, 63-69.
39. Shackelford, D. A., Tobaru, T., Zhang, S. et al. (1999) Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion. J. Neurosci. 19, 4727-4738.
40. Schenberg, M. H., Birk, D., Berger, H. G. (1995a) Oxidative stress in acute and chronic pancreatitis. Am. J. Clin. Nutr. 62, 1306S-1314S.
41. Schenberg, M. H., Buchler, M., Pietrzyk, C. (1995b) Lipid peroxidation and glutathione metabolism in chronic pancreatitis. Pancreas 10, 36-43.
42. Schenberg, M. H., Buchler, M., Berger, H. G. (1988) Lipid peroxidation products in the pancreatic tissue of patients with acute pancreatitis. Br. J. Surg. 75, 1254-1262.
43. Scott, P., Bruce, C., Schofield, D. (1993) Vitamin C status in patients with acute pancreatitis. Br. J. Surg. 80, 750-754.
44. Song, Q., Lees-Miller, S. P., Kumar, S. (1996) DNA-sependent protein kinase catalytic subunit: a arget for an ICE-like protease in apoptosis. EMBO J. 15, 3238-3246.
45. Teoh, G., Urashima, M., Greenfield, E. A. et al. (1998) The 86-kD subunit autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells. J. Clin. Invest. 101, 1379-1383.
46. Teraoka, H., Yumoto, Y., Yatanabe, F. et al. (1996) CPP32/yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme. FEBS Lett. 393, 1-6.
47. Yu, J. H., Lim, J. W., Kim, K. H. et al. (2005) NADPH oxidase and apoptosis in cerulein - stimulated pancreatic acinar cells. Free Rad. Biol. Med. 39, 590-602.
48. Yu, J. H., Lim, J. W., Namkung, W. et al. (2002) Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells. Lab. Inv. 82, 1359-1368.
49. Zar, B. H. (1984) Biostatistical Analysis. Englewood Cliffs, New Jergy: Prentice-Hall.