Effects of cycloheximide on pancreatic endonuclease activity, apoptosis, and severity of acute pancreatitis

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 3 40-3, 1996, Pages

  Kaiser, Andreas M ^a   Saluja, Ashok K ^a   Lu, Li ^a   Yamanaka, Kenji ^a   Yamaguchi, Yoshikazu ^a   Steer, Michael L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

acinar cell; acute disease; bile pancreatic duct obstruction necrosis; cell death; inhibition of protein synthesis; pancreas

Indexed keywords

CALCIUM; CYCLOHEXIMIDE; DNA FRAGMENT; ENDONUCLEASE; MAGNESIUM; PANCREAS ENZYME;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMMON BILE DUCT OBSTRUCTION; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS DUCT LIGATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT;

EID: 0029836691     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.3.c982     Document Type: Article

References (51)

1. Arends, M. J., R. G. Morris, and A. H. Wyllie. Apoptosis-the role of the endonuclease. Am. J. Pathol. 136: 593-608, 1990.
2. Barres, B. A., I. K. Hart, H. S. R. Coles, J. F. Burne, J. T. Voyvodic, W. D. Richardson, and M. C. Raff. Cell death and control of cell survival in the oligodendrocyte lineage. Cell 70: 31-46, 1992.
3. Boquist, L., and C. Edström. Ultrastructure of pancreatic acinar and islet parenchyma in rats at various intervals after duct ligation. Virchows Arch. 349: 69-79, 1970.
4. Cohen, J. J., and R. C. Duke. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132: 38-42, 1984.
5. Debbas, M., and E. White. Wild-type p53 mediates apoptosis by E1A which inhibited by E1B. Genes Dev. 7: 546-554, 1993.
6. Duke, R. C., R. Chervenak, and J. J. Cohen. Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis. Proc. Natl. Acad. Sci USA 80: 6361-6365, 1983.
7. Ellis, R. E., J. Yuan, and H. R. Horvitz. Mechanisms and functions of cell death. Annu. Rev. Cell Biol. 7: 663-698, 1991.
8. Fesus, L., V. Thomazy, and A. Falus. Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett. 224: 104-108, 1987.
9. Filipski, J., J. Leblanc, T. Youdale, M. Sikorska, and P. R. Walker. Periodicity of DNA folding in higher order chromatin structures. EMBO J. 9: 1319-1327, 1990.
10. Fisher, D. E. Apoptosis in cancer therapy: crossing the threshold. Cell 78: 539-542, 1994.
11. Frisch, S. M., and H. Francis. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124: 619-626, 1994.
12. Gaido, M. L., and J. A. Cidlowski. Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. J. Biol. Chem. 266: 18580-18585, 1991.
13. Gerschenson, L. E., and R. J. Rotello. Apoptosis: a different type of cell death. FASEB J. 6: 2450-2455, 1992.
14. Kaiser, A. M., A. K. Saluja. A. Sengupta, M. Saluja, and M. L. Steer. Relationship between severity, necrosis and apoptosis in five models of experimental acute pancreatitis. Am. J. Physiol. 269 (Cell Physiol. 38): C1295-C1304, 1995.
15. Kerr, J. F., A. H. Wyllie, and A. R. Currie. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257, 1972.
16. Labarca, C., and K. Paigen. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102: 344-352, 1980.
17. Ledda-Columbano, G. M., P. Coni, G. Faa, G. Manenti, and A. Columbano. Rapid induction of apoptosis in rat liver by cycloheximide. Am. J. Pathol. 140: 545-549, 1992.
18. Lockshin, R. A., and Z. Zakeri. Programmed cell death and apoptosis. In: Apoptosis: The Molecular Basis of Cell Death, edited by L. D. Tomei and F. O. Cope. Cold Spring Harbor, NY: Cold Spring Harbor, 1991, p. 47-60.
19. Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. p53 Is required for radiation-induced apoptosis in mouse thymocytes. Nature Lond. 362: 847-849, 1993.
20. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
21. Martin, S. J., S. V. Lennon, A. M. Bonham, and T. G. Cotter. Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA and protein synthesis. J. Immunol. 145: 1859-1867, 1990.
22. Marzluff, W. F. Preparation of active nuclei. Methods Enzymol. 181: 30-36, 1990.
23. 2+-mediated endonuclease activation. Science Wash. DC 242: 256-259, 1988.
24. McConkey, D. J., P. Hartzell, P. Nicotera, and S. Orrenius. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J. 3: 1843-1849, 1989.
25. McConkey, D. J., P. Hartzell, and S. Orrenius. Rapid turnover of endogenous endonuclease activity in thymocytes: effects of inhibitors of macromolecular synthesis. Arch. Biochem. Biophys. 278: 284-287, 1990.
26. Mogil, R. J., Y. Shi, R. P. Bissonnette, P. Bromley, I. Yamaguchi, and D. R. Green. Role of DNA fragmentation in T cell activation-induced apoptosis in vitro and in vivo. J. Immunol. 152: 1674-1683, 1994.
27. Odaka, C., H. Kizaki, and T. Tadakuma. T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas. J. Immunol. 144: 2096-2101, 1990.
28. Ohshio, G., A, Saluja, and M. L. Steer. Effects of short-term pancreatic duct obstruction in rats. Gastroenterology 100: 196-202, 1991.
29. Oppenheim, R. W., D. Prevette, M. Tytell, and S. Homma. Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev. Biol. 138: 104-113, 1990.
30. Peitsch, M. C., H. G. Mannherz, and J. Tschopp. The apoptosis endonucleases: cleaning up after cell death? Trends Cell Biol. 4: 37-41, 1994.
31. Peitsch, M. C., B. Polzar, H. Stephan, T. Crompton, H. R. MacDonald, H. G. Mannherz, and J. Tschopp. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12: 371-377, 1993.
32. Pierre, K. J., K. K. Tung, and H. Nadj. A new enzymatic kinetic method for the determination of alpha amylase (Abstract). Clin. Chem. 22: 1219, 1976.
33. 2+-dependent endonuclease from human spleen: purification, properties, and role in apoptosis. Biochemistry 32: 9129-9136, 1993.
34. Ruoslahti, E., and J. C. Reed. Anchorage dependence, integrins, and apoptosis. Cell 77: 477-478, 1994.
35. Saluja, A., I. Saito, M. Saluja, M. J. Houlihan, R. E. Powers, J. Meldolesi, and M. L. Steer. In vivo rat pancreatic acinar cell function during supramaximal stimulation with caerulein. Am. J. Physiol. 249 (Gastrointest. Liver Physiol. 12): G702-G710, 1985.
36. Sambrook, J., E. F. Fritsch, and T. Maniatis (Editors). Molecular Cloning, A Laboratory Manual (2nd ed.). Cold Spring Harbor, NY: Cold Spring Harbor, 1989.
37. Schwartzman, R. A., and J. A. Cidlowski. Mechanism of tissue-specific induction of internucleosomal deoxyribonucleic acid cleavage activity and apoptosis by glucocorticoids. Endocrinology 133: 591-599, 1993.
38. Shortman, K., and R. Scollay. Death in the thymus. Nature Lond. 372: 44-45, 1994.
39. Steer, M. L. Pathobiology of experimental acute pancreatitis. Yale J. Biol. Med. 65: 421-430, 1992.
40. Steer, M. L. Etiology and pathophysiology of acute pancreatitis. In: The Pancreas. Biology, Pathobiology and Disease (2nd ed.), edited by V. L. W. Go, E. P. DiMagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. New York: Raven, 1993, p. 581-591.
41. Steer, M. L., and A. K. Saluja. Experimental acute pancreatitis: studies of the early events that lead to cell injury. In: The Pancreas. Biology, Pathobiology and Disease (2nd ed.), edited by V. L. W. Go, E. P. DiMagno, J. D. Gardner, E. Lebenthal, H. A. Reber, and G. A. Scheele. New York: Raven, 1993, p. 489-500.
42. Steinberg, W., and S. Tenner. Acute pancreatitis. N. Engl. J. Med. 330: 1198-1210, 1994.
43. Steller, H. Mechanisms and genes of cellular suicide. Science Wash. DC 267: 1445-1449, 1995.
44. Stewart, B. W. Mechanisms of apoptosis: integration of genetic, biochemical, and cellular indicators. J. Natl. Cancer Inst. 86: 1286-1296, 1994.
45. 2+-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis. J. Biol. Chem. 269: 14857-14860, 1994.
46. Walker, N. I. Ultrastructure of the rat pancreas after experimental duct ligation. I. The role of apoptosis and intraepithelial macrophages in acinar cell deletion. Am. J. Pathol. 126: 439-451, 1987.
47. Walker, P. R., C. Smith, T. Youdale, J. Leblanc, J. F. Whitfield, and M. Sikorska. Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res. 51: 1078-1085, 1991.
48. Wallenfels, K., P. Foldi, H. Niermann, H. Bender, and D. Linder. The enzyme synthesis by transglucosylation of a homologous series of glucosidically substituted maltooligosaccharides, and their use as amylase substrates (Abstract). Carbohydr. Res. 61: 359, 1978.
49. Wyllie, A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature Lond. 284: 555-556, 1980.
50. Wyllie, A. H., J. F. Kerr, and A. R. Currie. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68: 251-306, 1980.
51. Wyllie, A. H., R. G. Morris, A. L. Smith, and D. Dunlop. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142: 67-77, 1984.