Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis

British Journal of Pharmacology

Volumn 153, Issue 3, 2008, Pages 508-516

  Guns, P J ^a   Van Assche, T ^a   Verreth, W ^b   Fransen, P ^a   Mackness, B ^c   Mackness, M ^c   Holvoet, P ^b   Bult, H ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

ApoE; Atherosclerosis; Endothelial dysfunction; Oxidative stress; Paraoxonase 1; Vascular smooth muscle cells

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASE; APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE 1; CYCLOPIAZONIC ACID; URIDINE TRIPHOSPHATE;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CALCIUM CELL LEVEL; CELL FUNCTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TRANSFER; HYPERCHOLESTEROLEMIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASOMOTOR REFLEX; WILD TYPE;

ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; ARYLDIALKYLPHOSPHATASE; ATHEROSCLEROSIS; CALCIUM; ENDOTHELIUM, VASCULAR; GENE TRANSFER TECHNIQUES; HOMEOSTASIS; HUMANS; LIPOPROTEINS, LDL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; TRANSFECTION; VASODILATION;

EID: 38849119157     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707585     Document Type: Article

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