Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 21, Issue 1, 2001, Pages 95-100

  Tsimikas, Sotirios ^a,b   Palinski, Wulf ^a   Witztum, Joseph L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Atherosclerosis; Autoantibodies; Lipoproteins; Progression; Regression

Indexed keywords

AUTOANTIBODY; LOW DENSITY LIPOPROTEIN RECEPTOR; MALONALDEHYDE; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTERY INTIMA; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CONTROLLED STUDY; EXTRACELLULAR SPACE; FOAM CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; LIPID COMPOSITION; LIPID PEROXIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0035170772     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.21.1.95     Document Type: Article

References (40)

1. The oxidative modification hypothesis of atherosclerosis
2. Low density lipoprotein undergoes oxidative modification in vivo
3. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man
4. Lipids and oxidised lipids in human atherosclerotic lesions at different stages of development
5. Mature human atherosclerotic plaque contains peroxidized phosphatidylcholine as a major lipid peroxide
6. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of alpha-to-copherol and ascorbate
7. Risk of thrombosis in human atherosclerotic plaques: Role of extracellular lipid, macrophage, and smooth muscle cell content
8. Relation of plaque lipid composition and morphology to the stability of human aortic plaques
9. Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
10. Malondialdehyde-modified LDL as a marker of acute coronary syndromes
11. Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis
12. Atherogenesis and inflammation
13. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum
14. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice: Demonstration of epitopes of oxidized low density lipoprotein in human plasma
15. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits
16. Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits
17. Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit
18. Radiolabeled MDA2, an oxidation-specific, monoclonal antibody, identifies native atherosclerotic lesions in vivo
19. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein
20. Is oxidized low-density lipoprotein present in vivo?
21. Increased autoantibody titers against epitopes of oxidized LDL in LDL receptor-deficient mice with increased atherosclerosis
22. In vivo uptake of radiolabeled MDA2, an oxidation-specific monoclonal antibody, provides an accurate measure of atherosclerotic lesions rich in oxidized LDL and is highly sensitive to their regression
23. Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids: Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low-density lipoprotein
24. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein
25. Autoantibody against oxidised LDL and progression of carotid atherosclerosis
26. Antibody against oxidized low-density lipoprotein predicting myocardial infarction
27. Antibodies against cardiolipin and oxidatively modified LDL in 50-year-old men predict myocardial infarction
28. Patients with early-onset peripheral vascular disease have increased levels of autoantibodies against oxidized LDL
29. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia: Role of oxidized LDL
30. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both
31. Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease
32. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than the induction of high titers of antibodies to oxidative neoepitopes
33. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
34. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice
35. Oxidized lipids in the diet accelerate the development of fatty streaks in cholesterol-fed rabbits
36. Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits
37. Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice
38. Immunological evidence for the presence of advanced glycosylation end products in atherosclerotic lesions of euglycemic rabbits
39. Lipids of human atheroma, 8: Oxidised derivatives of cholesteryl linoleate
40. Development of transplantation vasculopathy and progression of donor-transmitted athersclerosis: Comparison by serial intravascular ultrasound imaging