Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5

Current Drug Metabolism

Volumn 9, Issue 1, 2008, Pages 20-33

  Niwa, Toshiro ^a   Murayama, Norie ^a   Emoto, Chie ^a   Yamazaki, Hiroshi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

CYP3A4; CYP3A5; Genetic polymorphism; Inhibition constant; Mechanism based inhibition; Metabolic activity

Indexed keywords

ANESTHETIC AGENT; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIARRHYTHMIC AGENT; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIFUNGAL AGENT; ANTIHISTAMINIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; ANTIPROTOZOAL AGENT; ANTITUSSIVE AGENT; ANTIVIRUS AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIOVASCULAR AGENT; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; GASTROINTESTINAL AGENT; HYPNOTIC AGENT; IMMUNOSUPPRESSIVE AGENT; INSECTICIDE; NEUROLEPTIC AGENT; OPIATE; PSYCHOTROPIC AGENT; SEDATIVE AGENT; STEROID HORMONE; UNINDEXED DRUG; VASODILATOR AGENT;

COMPETITIVE INHIBITION; DEMETHYLATION; DRUG CLEARANCE; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; IC 50; LIVER MICROSOME; MICHAELIS MENTEN KINETICS; REVIEW;

ASIAN CONTINENTAL ANCESTRY GROUP; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; HUMANS; OXIDATION-REDUCTION; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; POLYMORPHISM, GENETIC; SUBSTRATE SPECIFICITY;

EID: 38849106780     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008783331121     Document Type: Review

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