Excitatory effects of human immunodeficiency virus 1 Tat on cultured rat cerebral cortical neurons

Neuroscience

Volumn 151, Issue 3, 2008, Pages 701-710

  Brailoiu, G C ^a   Brailoiu, E ^a   Chang, J K ^b   Dun, N J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PHOENIX PHARMACEUTICALS INC   (United States)

Author keywords

calcium imaging; electrophysiology; postsynaptic currents

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; CALCIUM; CITRIC ACID; GLUTAMIC ACID; HUMAN IMMUNODEFICIENCY VIRUS 1 TAT PROTEIN; NEUROTOXIN; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CELL POPULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEPOLARIZATION; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MEMBRANE RESISTANCE; NERVE CELL; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; VOLTAGE CLAMP;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BICUCULLINE; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; GABA ANTAGONISTS; HUMANS; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; THIOBARBITURATES;

EID: 38749114261     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.11.031     Document Type: Article

References (39)

1. Aksenov M.Y., Aksenova M.V., Nath A., Ray P.D., Mactutus C.F., and Booze R.M. Cocaine-mediated enhancement of Tat toxicity in rat hippocampal cell cultures: The role of oxidative stress and D1 dopamine receptor. Neurotoxicology 27 (2006) 217-228
2. Augustine G.J., Santamaria F., and Tanaka K. Local calcium signaling in neurons. Neuron 40 (2003) 331-346
3. Behnisch T., Francesconi W., and Sanna P.P. HIV secreted protein Tat prevents long-term potentiation in the hippocampal CA1 region. Brain Res 1012 (2004) 187-189
4. Bonavia R., Bajetto A., Barbero S., Albini A., Noonan D.M., and Schettini G. HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons. Biochem Biophys Res Commun 288 (2001) 301-308
5. 2+ overload and neuronal death in cultured rat cortical neurons. J Neurovirol 12 (2006) 17-24
6. Brailoiu E., and Miyamoto M.D. Inositol trisphosphate and cyclic adenosine diphosphate-ribose increase quantal transmitter release at frog motor nerve terminals: possible involvement of smooth endoplasmic reticulum. Neuroscience 95 (2000) 927-931
7. 2+ stores: Critical role for nicotinic acid adenine dinucleotide phosphate (NAADP). Biochem J 373 (2003) 313-318
8. Brailoiu G.C., Lai C.C., Chen C.T., Hwang L.L., Lin H.H., and Dun N.J. Sympathoinhibitory action of nociceptin in the rat spinal cord. Clin Exp Pharmacol Physiol 29 (2002) 233-237
9. Brauner T., Hulser D.F., and Strasse R.J. Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes. Biochem Biophys Acta 771 (1984) 208-216
10. Chen Y., Geisler W.S., and Seidemann E. Optimal decoding of correlated neural population responses in the primate visual cortex. Nat Neurosci 9 (2006) 1412-1420
11. Cheng J., Nath A., Knudsen B., Hochman S., Geiger J.D., Ma M., and Magnuson D.S. Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein. Neuroscience 82 (1998) 97-106
12. Clark III J.P., Sampair C.S., Kofuji P., Nath A., and Ding J.M. HIV protein, transactivator of transcription, alters circadian rhythms through the light entrainment pathway. Am J Physiol Regul Integr Comp Physiol 289 (2005) R656-R662
13. Connor J.A. Digital imaging of free calcium changes and of spatial gradients in growing processes in single, mammalian central nervous system cells. Proc Natl Acad Sci U S A 83 (1986) 6179-6183
14. Ebner T.J., and Chen G. Use of voltage-sensitive dyes and optical recordings in the central nervous system. Prog Neurobiol 46 (1995) 463-506
15. Feligioni M., Raiteri L., Pattarini R., Grilli M., Bruzzone S., Cavazzani P., Raiteri M., and Pittaluga A. The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms. J Neurosci 23 (2003) 6810-6818
16. Gonzalez-Scarano F., and Martin-Garcia J. The neuropathogenesis of AIDS. Nat Rev Immunol 5 (2005) 69-81
17. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260 (1985) 3440-3450
18. Haughey N.J., Holden C.P., Nath A., and Geiger J.D. Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein Tat. J Neurochem 73 (1999) 1363-1374
19. Haughey N.J., Nath A., Mattson M.P., Slevin J.T., and Geiger J.D. HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity. J Neurochem 78 (2001) 457-467
20. Haughey N.J., and Mattson M.P. Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120. J Acquir Immune Defic Syndr 31 (2002) S55-S61
21. Kaul M., Garden G.A., and Lipton S.A. Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410 (2001) 988-994
22. Kruman I.I., Nath A., and Mattson M.P. HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress. Exp Neurol 154 (1998) 276-288
23. Kunkler P.E., Hulse R.E., Schmitt M.W., Nicholson C., and Kraig R.P. Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents. J Neurosci 25 (2005) 3952-3961
24. Li S.T., Matsushita M., Moriwaki A., Saheki Y., Lu Y.F., Tomizawa K., Wu H.Y., Terada H., and Matsui H. HIV-1 Tat inhibits long-term potentiation and attenuates spatial learning. Ann Neurol 55 (2004) 362-371
25. Magnuson D.S., Knudsen B.E., Geiger J.D., Brownstone R.M., and Nath A. Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity. Ann Neurol 37 (1995) 373-380
26. Maragos W.F., Tillman P., Jones M., Bruce-Keller A.J., Roth S., Bell J.E., and Nath A. Neuronal injury in hippocampus with human immunodeficiency virus transactivating protein, Tat. Neuroscience 117 (2003) 43-53
27. 2+ of NMDA responses in spinal cord neurones. Nature 309 (1984) 261-263
28. Nath A., Psooy K., Martin C., Knudsen B., Magnuson D.S., Haughey N., and Geiger J.D. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 70 (1996) 1475-1480
29. New D.R., Ma M., Epstein L.G., Nath A., and Gelbard H.A. Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures. J Neurovirol 3 (1997) 168-173
30. Perez A., Probert A.W., Wang K.K., and Sharmeen L. Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture. J Neurovirol 7 (2001) 1-10
31. Perry S.W., Norman J.P., Litzburg A., Zhang D., Dewhurst S., and Gelbard H.A. HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. J Immunol 174 (2005) 4333-4344
32. Philippon V., Vellutini C., Gambarelli D., Harkiss G., Arbuthnott G., Metzger D., Roubin R., and Filippi P. The basic domain of the lentiviral Tat protein is responsible for damages in mouse brain: involvement of cytokines. Virology 205 (1994) 519-529
33. Prange O., and Murphy T.H. Correlation of miniature synaptic activity and evoked release probability in cultures of cortical neurons. J Neurosci 19 (1999) 6427-6438
34. Sabatier J.M., Vives E., Mabrouk K., Benjouad A., Rochat H., Duval A., Hue B., and Bahraoui E. Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J Virol 65 (1991) 961-967
35. Schoniger S., Wehming S., Gonzalez C., Schobitz K., Rodriguez E., Oksche A., Yulis C.R., and Nurnberger F. The dispersed cell culture as model for functional studies of the subcommissural organ: preparation and characterization of the culture system. J Neurosci Methods 107 (2001) 47-61
36. 2+ that require function of an N-methyl-D-aspartate receptor polyamine-sensitive site. Brain Res 995 (2004) 39-45
37. Singh I.N., Goody R.J., Dean C., Ahmad N.M., Lutz S.E., Knapp P.E., Nath A., and Hauser K.F. Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G. J Neurovirol 10 (2004) 141-151
38. Song L., Nath A., Geiger J.D., Moore A., and Hochman S. Human immunodeficiency virus type 1 Tat protein directly activates neuronal N-methyl-D-aspartate receptors at an allosteric zinc-sensitive site. J Neurovirol 9 (2003) 399-403
39. Wu S.Y., Ohtubo Y., Brailoiu G.C., and Dun N.J. Effects of endomorphin on substantia gelatinosa neurons in rat spinal cord slices. Br J Pharmacol 140 (2003) 1088-1096