Acute exposure to ethanol potentiates human immunodeficiency virus type 1 Tat-induced Ca2+ overload and neuronal death in cultured rat cortical neurons

Journal of NeuroVirology

Volumn 12, Issue 1, 2006, Pages 17-24

  Brailoiu, Eugen ^a   Brailoiu, Christina G ^a   Mameli, Giuseppe ^a,b   Dolei, Antonina ^b   Sawaya, Bassel E ^a   Dun, Nae J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SASSARI   (Italy)

Author keywords

HIV 1; Neurotoxicity; Tat protein

Indexed keywords

ALCOHOL; CALCIUM; TRANSACTIVATOR PROTEIN; TRYPAN BLUE; VIRUS PROTEIN;

ANALYSIS OF VARIANCE; ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; MICROFLUOROMETRY; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS VIRULENCE;

ANIMALS; CALCIUM; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; ETHANOL; GENE PRODUCTS, TAT; HIV-1; KINETICS; NEURONS; RATS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33645786557     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280500516427     Document Type: Article

References (52)

1. Acheampong, E and Mukhtar, M and Parveen, Z and Ngoubilly, N and Ahmad, N and Patel, C and Pomerantz, R. (2002) Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells Virology, 304, pp. 222 - 234. [PUBMED] [INFOTRIEVE] [CSA]
2. WAF1 gene expression in human astrocytes J Biol Chem, 279, pp. 46046 - 46056. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
3. Belmadani, A and Neafsey, E and Collins, M. (2003) Human immunodeficiency virus type 1 gp120 and ethanol coexposure in rat organotypic brain slice cultures: Curtailment of gp120-induced neurotoxicity and neurotoxic mediators by moderate but not high ethanol concentrations J NeuroVirol, 9, pp. 45 - 54. [PUBMED] [INFOTRIEVE] [CSA]
4. 2+ -mediated neurotoxicity Neuroscience, 104, pp. 769 - 781. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
5. Bonavia, R and Bajetto, A and Barbero, S and Albini, A and Noonan, D and Schettini, G. (2001) HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons Biochem Biophys Res Commun, 288, pp. 301 - 308. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
6. Brailoiu, E and Hoard, J and Filipeanu, C and Brailoiu, G and Dun, S and Patel, S and Dun, N. (2005) NAADP potentiates neurite outgrowth J Biol Chem, 280, pp. 5646 - 5650. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
7. Chen, H and Zha, J and Gowans, R and Camargo, P and Nishitani, J and McQuirter, J and Cole, S and Zack, J and Liu, X. (2004) Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor AIDS Res Hum Retroviruses, 20, pp. 513 - 519. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
8. Chen, W and Tang, Z and Fortina, P and Patel, P and Addya, S and Surrey, S and Acheampong, E and Mukhtar, M and Pomerantz, R. (2005) Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways Virology, 334, pp. 59 - 73. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
9. Collins, M and Neafsey, E and Zou, J. (2000) HIV-I gpI20 neurotoxicity in brain cultures is prevented by moderate ethanol pretreatment Neuroreport, 11, pp. 1219 - 1222. [PUBMED] [INFOTRIEVE] [CSA]
10. Cook, R and Stapleton, J and Dallas, Z and Klinzman, D. (1997) Effect of a single ethanol exposure on HIV replication in human lymphocytes J Invest Med, 45, pp. 265 - 271. [CSA]
11. Dingle, G and Oei, T. (1997) Is alcohol a cofactor of HIV and AIDS? Evidence from immunological and behavioral studies Psychol Bull, 122, pp. 56 - 71. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
12. Daniell, L and Harris, R. (1989) Ethanol and inositol 1,4,5-trisphosphate release calcium from separate stores of brain microsomes J Pharmacol Exp Ther, 250, pp. 875 - 881. [PUBMED] [INFOTRIEVE] [CSA]
13. Flora, G and Pu, H and Lee, Y and Ravikumar, R and Nath, A and Hennig, B and Toborek, M. (2005) Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue Exp Neurol, 191, pp. 2 - 12. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
14. Ghosh, A and Greenberg, M. (1995) Calcium signaling in neurons: molecular mechanisms and cellular conseqences Science, 268, pp. 239 - 247. [PUBMED] [INFOTRIEVE] [CSA]
15. Goodlett, C and Horn, K. (2001) Mechanisms of alcohol-induced damage to the developing nervous system Alcohol Res Health, 25, pp. 175 - 184. [PUBMED] [INFOTRIEVE] [CSA]
16. Gonzalez-Scarano, F and Martin-Garcia, J. (2005) The neuropathogenesis of AIDS Nat Rev Immunol, 5, pp. 69 - 81. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
17. Green, J and Tran, T and Steinmetz, J and Goodlett, C. (2002) Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats Brain Res, 956, pp. 302 - 311. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
18. 2+ indicators with greatly improved fluorescence properties J Biol Chem, 260, pp. 3440 - 3450. [PUBMED] [INFOTRIEVE] [CSA]
19. Haorah, J and Heilman, D and Diekmann, C and Osna, N and Donohue, T, Jr and Ghorpade, A and Persidsky, Y. (2004) Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease Cell Immunol, 229, pp. 139 - 148. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
20. Haughey, N and Holden, C and Nath, A and Geiger, J. (1999) Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat J Neurochem, 73, pp. 1363 - 1374. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
21. Haughey, N and Mattson, M. (2002) Calcium dysregulation and neuronal apoptosis by the HIV-1 proteins Tat and gp120 J Acquir Immune Defic Syndr, 31, pp. S55 - S61. [PUBMED] [INFOTRIEVE] [CSA]
22. Haughey, N and Nath, A and Mattson, M and Slevin, J and Geiger, J. (2001) HIV-1 Tat through phosphorylation of NMDA receptors potentiates glutamate excitotoxicity J Neurochem, 78, pp. 457 - 467. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
23. Hoek, J and Thomas, A and Rubin, R and Rubin, E. (1987) Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes J Biol Chem, 262, pp. 682 - 691. [PUBMED] [INFOTRIEVE] [CSA]
24. Ikegami, Y and Goodenough, S and Inoue, Y and Dodd, P and Wilce, P and Matsumoto, I. (2003) Increased TUNEL positive cells in human alcoholic brains Neurosci Lett, 349, pp. 201 - 205. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
25. Ikonomidou, C and Bittigau, P and Ishimaru, M and Wozniak, D and Koch, C and Genz, K and Price, M and Stefovska, V and Horster, F and Tenkova, T and Dikranian, K and Olney, J. (2000) Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome Science, 287, pp. 1056 - 1060. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
26. Kaul, M and Garden, G and Lipton, S. (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia Nature, 410, pp. 988 - 994. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
27. 2+ increase in cultured cortical astrocytes Eur J Neurosci, 14, pp. 1793 - 1799. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
28. Kruman, I and Nath, A and Mattson, M. (1998) HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress Exp Neurol, 154, pp. 276 - 288. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
29. Liu, X and Zha, J and Nishitani, J and Chen, H and Zack, J. (2003) HIV-1 infection in peripheral blood lymphocytes (PBLs) exposed to alcohol Virology, 307, pp. 37 - 44. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
30. Meyerhoff, D. (2001) Effects of alcohol and HIV infection on the central nervous system Alcohol Res Health, 25, pp. 288 - 298. [PUBMED] [INFOTRIEVE] [CSA]
31. Mattson, M and Chan, S. (2003) Calcium orchestrates apoptosis Nat Cell Biol, 5, pp. 1041 - 1043. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
32. Mattson, M and Haughey, N and Nath, A. (2005) Cell death in HIV dementia Cell Death Differ, 12, pp. 893 - 904. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
33. Mayne, M and Holden, C and Nath, A and Geiger, J. (2000) Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages J Immunol, 164, pp. 6538 - 6542. [PUBMED] [INFOTRIEVE] [CSA]
34. Nagy, J and Muller, F and Laszlo, L. (2001) Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurones Drug Alcohol Depend, 61, pp. 155-162. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
35. Nath, A and Geiger, J. (1998) Neurobiological aspects of human immunodeficiency virus infection: Neurotoxic mechanisms Prog Neurobiol, 54, pp. 19-33. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
36. Nath, A and Psooy, K and Martin, C and Knudsen, B and Magnuson, D and Haughey, N and Geiger, J. (1996) Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic J Virol, 70, pp. 1475-1480. [PUBMED] [INFOTRIEVE] [CSA]
37. New, D and Ma, M and Epstein, L and Nath, A and Gelbard, H. (1997) Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures J NeuroVirol, 3, pp. 168-173. [PUBMED] [INFOTRIEVE] [CSA]
38. Pandey, S. (1996) Acute and chronic ethanol consumption effects on the immunolabeling of Gq/11 alpha subunit protein and phospholipase C isozymes in the rat brain J Neurochem, 67, pp. 2355-2361. [PUBMED] [INFOTRIEVE] [CSA]
39. Pawlak, R and Skrzypiec, A and Sulkowski, S and Buczko, W. (2002) Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus Neurosci Lett, 327, pp. 83-86. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
40. Pfefferbaum, A and Adalsteinsson, E and Sullivan, E. (2005) Cortical NAA deficits in HIV infection without dementia: Influence of alcoholism comorbidity Neuropsychopharmacology, 30, pp. 1392-1399. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
41. Popp, R and Lickteig, R and Lovinger, D. (1999) Factors that enhance ethanol inhibition of N-methyl-D-aspartate receptors in cerebellar granule cells J Pharmacol Exp Ther, 289, pp. 1564-1574. [PUBMED] [INFOTRIEVE] [CSA]
42. Resnick, L and Berger, J and Shapshak, P and Tourtellotte, W. (1988) Early penetration of the blood-brain barrier by HTLV-III/LAV Neurology, 38, pp. 9-15. [PUBMED] [INFOTRIEVE] [CSA]
43. Rothlind, J and Greenfield, T and Bruce, A and Meyerhoff, D and Flenniken, D and Lindgren, J and Weiner, M. (2005) Heavy alcohol consumption in individuals with HIV infection: Effects on neuropsychological performance J Int Neuropsychol Soc, 11, pp. 70-83. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
44. Sabatier, J and Vives, E and Mabrouk, K and Benjouad, A and Rochat, H and Duval, A and Hue, B and Bahraoui, E. (1991) Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1 J Virol, 65, pp. 961-967. [PUBMED] [INFOTRIEVE] [CSA]
45. Samet, J and Phillips, S and Morton, N and Traphagen, E and Freedberg, K. (2004) Detecting alcohol problems in HIV-infected patients: Use of the CAGE questionnaire AIDS Res Hum Retroviruses, 20, pp. 151-155. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
46. Schulte, T and Mueller-Oehring, E and Rosenbloom, M and Pfefferbaum, A and Sullivan, E. (2005) Differential effect of HIV infection and alcoholism on conflict processing, attentional allocation, and perceptual load: Evidence from a Stroop Match-to-Sample task Biol Psychol, 57, pp. 67-75. [CROSSREF] [CSA]
47. Self, R and Mulholland, P and Harris, B and Nath, A and Prendergast, M. (2004) Cytotoxic effects of exposure to the human immunodeficiency virus type 1 protein Tat in the hippocampus are enhanced by prior ethanol treatment Alcohol Clin Exp Res, 28, pp. 1916-1924. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
48. 2+ in the cytosol Biochem J, 344, pp. 39-46. [PUBMED] [INFOTRIEVE] [CROSSREF] [CSA]
49. A or glycine receptors J Pharmacol Exp Ther, 290, pp. 362 - 367. [PUBMED] [INFOTRIEVE] [CSA]
50. Winsauer, P and Moerschbaecher, J and Brauner, I and Purcell, J and Lancaster, J, Jr and Bagby, G and Nelson, S. (2002) Alcohol unmasks simian immunodeficiency virus-induced cognitive impairments in rhesus monkeys Alcohol Clin Exp Res, 26, pp. 1846-1857. [PUBMED] [INFOTRIEVE] [CSA]
51. 2+ release in ethanol-induced contraction of cerebral arterial smooth muscle Alcohol, 24, pp. 145-153. [PUBMED] [INFOTRIEVE] [CSA]
52. Zheng, J and Yang, O and Xie, Y and Campbell, R and Chen, I and Pang, S. (2004) Ethanol stimulation of HIV infection of oral epithelial cells J Acquir Immune Defic Syndr, 37, pp. 1445-1453. [PUBMED] [INFOTRIEVE] [CSA]