PCB126 induces differential changes in androgen, cortisol, and aldosterone biosynthesis in human adrenocortical H295R cells

Toxicological Sciences

Volumn 85, Issue 1, 2005, Pages 530-540

  Li, Lih Ann ^a   Wang, Pei Wen ^b  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Adrenal steroidogenesis; cAMP induction; Cardiovascular diseases; Coplanar PCB; Diabetes; Steroidogenic genes

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANDROGEN; ANDROSTENEDIONE; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; CYCLIC AMP; CYTOCHROME P450; CYTOCHROME P450 11B1; CYTOCHROME P450 17; CYTOCHROME P450 21B; DIOXIN; HYDROCORTISONE; HYDROXYPROGESTERONE; MESSENGER RNA; PROGESTERONE; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; UNCLASSIFIED DRUG;

ADRENAL CORTEX CELL; ANDROGEN SYNTHESIS; ARTICLE; BLOOD VESSEL FUNCTION; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; ENZYME ACTIVITY; GENETIC CODE; GLUCOSE TOLERANCE; HEART VENTRICLE REMODELING; HIGH RISK POPULATION; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIPID METABOLISM; MESSENGER RNA SYNTHESIS; OBESITY; POPULATION EXPOSURE; PROTEIN EXPRESSION; PROTEIN INDUCTION; SENSITIZATION; STEROIDOGENESIS; TIME;

ADRENAL CORTEX; ALDOSTERONE; ANDROGENS; CELL LINE; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; HYDROCORTISONE; POLYCHLORINATED BIPHENYLS; RNA, MESSENGER; STEROID HYDROXYLASES; TIME FACTORS;

EID: 18144424027     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi105     Document Type: Article

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