Relaxation induced by red wine polyphenolic compounds in rat pulmonary arteries: Lack of inhibition by NO-synthase inhibitor

Fundamental and Clinical Pharmacology

Volumn 22, Issue 1, 2008, Pages 25-35

  Leblais, Véronique ^a,b   Krisa, Stéphanie ^c   Valls, Josep ^c   Courtois, Arnaud ^a,b   Abdelouhab, Sabrina ^a,b   Vila, Alicia Martin ^a,b   Mérillon, Jean Michel ^c   Muller, Bernard ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b CENTRE DE RECHERCHE CARDIO THORACIQUE DE BORDEAUX   (France)

^c Bordeaux Segalen University   (France)

Author keywords

Aorta; Endothelial NO synthase; Nitric oxide; Pulmonary artery; Red wine polyphenols; Resveratrol; Vasorelaxation

Indexed keywords

ANTHOCYANIN; ASTILBIN; CAFFEIC ACID; CATECHIN; DELPHINIDIN; EPICATECHIN; ISOQUERCITRIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PICEID; POLYPHENOL DERIVATIVE; QUERCETIN; RESVERATROL; STILBENE DERIVATIVE; VANILLIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; FRACTIONATION; LUNG ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RED WINE; VASODILATATION;

EID: 38649087027     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2007.00546.x     Document Type: Article

References (47)

1. Goldberg D.M., Hahn S.E., Parkes J.G. Beyond alcohol: beverage consumption and cardiovascular mortality. Clin. Chim. Acta (1995) 237 155 187.
2. Vitrac X., Monti J.P., Vercauteren J., Deffieux G., Mérillon J.M. Direct liquid chromatographic analysis of resveratrol derivatives and flavanonols in wines with absorbance and fluorescence detection. Anal. Chim. Acta (2002) 458 103 110.
3. Dell'Agli M., Busciala A., Bosisio E. Vascular effects of wine polyphenols. Cardiovasc. Res. (2004) 63 593 602.
4. Stoclet J.C., Chataigneau T., N'Diaye M. et al. Vascular protection by dietary polyphenols. Eur. J. Pharmacol. (2004) 500 299 313.
5. Li H., Forstermann U. Nitric oxide in the pathogenesis of vascular disease. J. Pathol. (2000) 190 244 254.
6. Gewaltig M.T., Kojda G. Vasoprotection by nitric oxide: mechanisms and therapeutic potentials. Cardiovasc. Res. (2002) 55 250 260.
7. Albrecht E.W., Stegeman C.A., Heeringa P., Henning R.H., van Goor H. Protective role of endothelial nitric oxide synthase. J. Pathol. (2003) 199 8 17.
8. Cai H., Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ. Res. (2000) 87 840 844.
9. Leikert J.F., Rathel T.R., Wohlfart P., Cheynier V., Vollmar A.M., Dirsch V.M. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation (2002) 106 1614 1617.
10. Wallerath T., Deckert G., Ternes T. et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation (2002) 106 1652 1658.
11. Wallerath T., Poleo D., Li H., Forstermann U. Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J. Am. Coll. Cardiol. (2003) 41 471 478.
12. Wallerath T., Li H., Godtel-Ambrust U., Schwarz P.M., Forstermann U. A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide (2005) 12 97 104.
13. Martin S., Giannone G., Andriantsitohaina R., Martinez M.C. Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis. Br. J. Pharmacol. (2003) 139 1095 1102.
14. Fitzpatrick D.F., Hirschfield S.L., Coffey R.G. Endothelium-dependent vasorelaxing activity of wine and other grape products. Am. J. Physiol. Heart Circ. Physiol. (1993) 265 H774 H778.
15. Andriambeloson E., Kleschyov A.L., Muller B., Beretz A., Stoclet J.C., Andriantsitohaina R. Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br. J. Pharmacol. (1997) 120 1053 1058.
16. Andriambeloson E., Magnier C., Haan-Archipoff G. et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J. Nutr. (1998) 128 2324 2333.
17. Martin S., Andriambeloson E., Takeda K., Andriantsitohaina R. Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br. J. Pharmacol. (2002) 135 1579 1587.
18. Ndiaye M., Chataigneau M., Lobysheva I., Chataigneau T., Schini-Kerth V.B. Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J. (2005) 19 455 457.
19. Sarr M., Chataigneau M., Martins S. et al. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc. Res. (2006) 71 794 802.
20. Fishman A.P. Hypoxia on the pulmonary circulation. How and where it acts. Circ. Res. (1976) 38 221 231.
21. Schäfer A., Bauersachs J. High-altitude pulmonary edema: potential protection by red wine. Nutr. Metab. Cardiovasc. Dis. (2002) 12 306 310.
22. 2+mobilization in human pulmonary arterial endothelial cells. Br. J. Pharmacol. (1998) 125 1180 1187.
23. Jacobs E.R., Zhu D., Gruenloh S., Lopez B., Medhora M. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. Am. J. Physiol. Lung Cell. Mol. Physiol. (2006) 291 L369 L377.
24. Li Z., Carter J.D., Dailey L.A., Huang Y.C. Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS. Environ. Health Perspect. (2004) 112 201 206.
25. Murata T., Kinoshita K., Hori M. et al. Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. Arterioscler. Thromb. Vasc. Biol. (2005) 25 2335 2342.
26. Vitrac X., Castagnino C., Waffo-Téguo P. et al. Polyphenols newly extracted in red wine from southwestern France by centrifugal partition chromatography. J. Agric. Food Chem. (2001) 49 5934 5938.
27. Waffo-Téguo P., Fauconneau B., Deffieux G., Huguet F., Vercauteren J., Mérillon J.M. Isolation, identification, and antioxidant activity of three stilbene glucosides newly extracted from Vitis vinifera cell cultures. J. Nat. Prod. (1998) 61 655 657.
28. Leblais V., Pourageaud F., Ivorra M.D., Guibert C., Marthan R., Muller B. Role of α-adrenergic receptors in the effect of the β-adrenergic receptors ligands, CGP 12177, bupranolol and SR 59230A, on the contraction of rat intrapulmonary artery. J. Pharmacol. Exp. Ther. (2004) 309 137 145.
29. Pourageaud F., Leblais V., Bellance N., Marthan R., Muller B. Role of beta2-adrenoceptors (beta-AR), but not beta1-, beta3-AR and endothelial nitric oxide, in beta-AR-mediated relaxation of rat intrapulmonary artery. Naunyn Schmiedebergs Arch. Pharmacol. (2005) 372 14 23.
30. Al-Awwadi N.A., Bornet A., Azay J. et al. Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat. J. Agric. Food Chem. (2004) 52 5593 5597.
31. Ndiaye M., Chataigneau T., Chataigneau M., Schini-Kerth V.B. Red wine polyphenols induce EDHF-mediated relaxations in porcine coronary arteries through the redox-sensitive activation of the PI3-kinase/Akt pathway. Br. J. Pharmacol. (2004) 142 1131 1136.
32. Varache-Lembège M., Waffo-Téguo P., Richard T. et al. Structure-activity relationships of polyhydroxystilbene derivatives extracted from Vitis vinifera cell cultures as inhibitors of human platelet aggregation. Med. Chem. Res. (2000) 10 253 267.
33. Chen C.K., Pace-Asciak C.R. Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta. Gen. Pharmacol. (1996) 27 363 366.
34. Orallo F., Alvarez E., Camina M., Leiro J.M., Gomez E., Fernandez P. The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol. Pharmacol. (2002) 61 294 302.
35. Rakici O., Kiziltepe U., Coskun B., Aslamaci S., Akar F. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. Int. J. Cardiol. (2005) 105 209 215.
36. Buluc M., Demirel-Yilmaz E. Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vascul. Pharmacol. (2006) 44 231 237.
37. Cruz M.N., Luksha L., Logman H., Poston L., Agewall S., Kublickiene K. Acute responses to phytoestrogens in small arteries from men with coronary heart disease. Am. J. Physiol. Heart Circ. Physiol. (2006) 290 H1969 H1975.
38. Li H.F., Tian Z.F., Qiu X.Q., Wu J.X., Zhang P., Jia Z.J. A study of mechanisms involved in vasodilatation induced by resveratrol in isolated porcine coronary artery. Physiol. Res. (2006) 55 365 372.
39. El-Mowafy A.M. Resveratrol activates membrane-bound guanylyl cyclase in coronary arterial smooth muscle: a novel signaling mechanism in support of coronary protection. Biochem. Biophys. Res. Commun. (2002) 291 1218 1224.
40. Duarte J., Perez-Vizcaino F., Zarzuelo A., Jimenez J., Tamargo J. Vasodilator effects of quercetin in isolated rat vascular smooth muscle. Eur. J. Pharmacol. (1993) 239 1 7.
41. Novakovic A., Bukarica L.G., Kanjuh V., Heinle H. Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol. Basic Clin. Pharmacol. Toxicol. (2006) 99 360 364.
42. 2. Role in vasodilatation. Cardiovasc. Res. (2007) 73 424 431.
43. Ajay M., Gilani A.U., Mustafa M.R. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. (2003) 74 603 612.
44. Cicala C., Morello S., Iorio C., Capasso R., Borrelli F., Mascolo N. Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta. Life Sci. (2003) 73 73 80.
45. Duarte J., Perez-Vizcaino F., Zarzuelo A., Jimenez J., Tamargo J. Inhibitory effects of quercetin and staurosporine on phasic contractions in rat vascular smooth muscle. Eur. J. Pharmacol. (1994) 262 149 156.
46. 2 in the endothelium-dependent contractions induced by myricetin in rat isolated aorta. Br. J. Pharmacol. (1999) 127 1539 1544.
47. Duthie G.G., Pedersen M.W., Gardner P.T. et al. The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur. J. Clin. Nutr. (1998) 52 733 736.