Oxidative damage in nucleic acids and Parkinson's disease

Journal of Neuroscience Research

Volumn 85, Issue 5, 2007, Pages 919-934

  Nakabeppu, Yusaku ^a   Tsuchimoto, Daisuke ^a   Yamaguchi, Hiroo ^a   Sakumi, Kunihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Nucleic acids; Oxidative damage; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2 HYDROXY 2' DEOXYADENOSINE TRIPHOSPHATE; 8 HYDROXYGUANINE; 8 OXO 2' DEOXYGUANOSINE TRIPHOSPHATE; ADENINE DERIVATIVE; CELL NUCLEUS DNA; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; GUANINE; HYDROGEN PEROXIDE; ISOGUANINE; MITOCHONDRIAL DNA; NUCLEAR PROTEIN; NUCLEIC ACID; PROTEIN MTH1; PURINE NUCLEOSIDE DERIVATIVE; PURINE NUCLEOSIDE TRIPHOSPHATE DERIVATIVE; UNCLASSIFIED DRUG;

BASE PAIRING; CELL DEATH; DNA DAMAGE; DNA REPLICATION; DOPAMINERGIC NERVE CELL; FIBROBLAST; GENE; HUMAN; MUTAGENESIS; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; OGG1 GENE; OXIDATION; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW;

ANIMALS; DNA GLYCOSYLASES; DNA REPAIR ENZYMES; DNA, MITOCHONDRIAL; GUANINE; HUMANS; MICE; NUCLEIC ACIDS; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHORIC MONOESTER HYDROLASES; SUBSTANTIA NIGRA;

EID: 34147204519     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21191     Document Type: Review

References (29)

1. Aburatani H, Hippo Y, Ishida T, Takashima R, Matsuba C, Kodama T, Takao M, Yasui A, Yamamoto K, Asano M. 1997. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res 57:2151-2156.
2. Alain ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P, Halliwell B. 1997. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem 69:1196-1203.
3. Ames BN, Shigenaga MK, Hagen TM. 1993. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci U S A 90:7915-7922.
4. Arai T. Fukae J, Hatano T, Kubo SI, Ohtsubo T, Nakabeppu Y, Mori H, Mizuno Y, Hattori N. 2006. Up-regulation of hMUTYH, a DNA repair enzyme, in the mitochondria of substantia nigra in Parkinson's disease. Acta Neuropathol 112:136-145.
5. Boiteux S, Radicella J P. 2000. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys 377:1-8.
6. +-induced mitochondrial DNA oxidative damage in vivo and in vitro. J Pineal Res 39:34-42.
7. Clarke DD, Sokoloff L. 1999. Circulation and energy metabolism in the brain. In: Siegel GJ, Arganoff BW, Albers RW, Fisher SK, Uhler MD, editors. Basic neurochemistry: molecular, cellullar and medical aspects, 6th ed. Philadelphia: Lippincott-Raven Publishers. p 637-669.
8. Cooke MS, Evans MD, Dizdaroglu M, Lunec J. 2003. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195-1214.
9. Englander EW, Hu Z, Sharma A, Lee HM, Wu ZH, Greeley GH. 2002. Rat MYH, a glycosylase for repair of oxidatively damaged DNA, has brain-specific isoforms that localize to neuronal mitochondria. J Neurochem 83:1471-1480.
10. Fujikawa K, Kamiya H, Yakushiji H, Fujii Y, Nakabeppu Y, Kasai H. 1999. The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein. J Biol Chem 274:18201-18205.
11. Fujikawa K, Kamiya H, Yakushiji H, Nakabeppu Y, Kasai H. 2001. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res 29:449-454.
12. Fukae J, Takanashi M, Kubo S-I, Nishioka K-I, Nakabeppu Y, Mori H, Mizuno Y, Hattori N. 2005. Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders. Acta Neurophathol 109:256-262.
13. Gu Y, Parker A, Wilson TM, Bai H, Chang DY, Lu AL. 2002. Human MutY homolog, a DNA glycosylase involved in base excision repair, physically and functionally interacts with mismatch repair proteins human MutS homolog 2/human MutS homolog 6. J Biol Chem 277:11135-11142.
14. Halliwell B. 1992. Reactive oxygen species and the central nervous system. J Neurochem 59:1609-1623.
15. Hayakawa H, Hofer A, Thelander L, Kitajima S, Cai Y, Oshiro S, Yakushiji H, Nakabeppu Y, Kuwano M, Sekiguchi M. 1999. Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. Biochemistry 38:3610-3614.
16. Hayashi H, Tominaga Y, Hirano S, McKenna AE, Nakabeppu Y, Matsumoto Y. 2002. Replication-associated repair of adenine: 8-oxoguanine mispairs by MYH. Curr Biol 12:335-339.
17. Hirano S, Tominaga Y, Ichinoe A, Ushijima Y, Tsuchimoto D, Honda-Ohnishi Y, Ohtsubo T, Sakumi K, Nakabeppu Y. 2003. Mutator phenotype of MUTYH-null mouse embryonic stem cells. J Biol Chem 278:38121-38124.
18. Ichinoe A, Behmanesh M, Tominaga Y, Ushijima Y, Hirano S, Sakai Y, Tsuchimoto D, Sakumi K, Wake N, Nakabeppu Y. 2004. Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res 32:477-487.
19. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH. 1985. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci U S A 82:2173-2177.
20. Jenner P. 2003. Oxidative stress in Parkinson's disease. Ann Neurol 53(Suppl 3):S26-S36; discussion S36-S38.
21. Kai T, Matsunaga R, Eguchi M, Kamiya H, Kasai H, Suzuki M, Izuta S. 2002. An oxidized nucleotide affects DNA replication through activation of protein kinases in Xenopus egg lysates. Nucleic Acids Res 30:569-573.
22. Kamiya H, Kasai H. 1995. Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation. J Biol Chem 270:19446-19450.
23. Kamiya H, Kasai H. 2000. 2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity. Nucleic Acids Res 28:1640-1646.
24. Kang D, Nishida J, Iyama A, Nakabeppu Y, Furuichi M, Fujiwara T, Sekiguchi M, Takeshige K. 1995. Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria. J Biol Chem 270:14659-14665.
25. Kang D, Takeshige K, Sekiguchi M, Singh KK. 1998. Introduction. In: Singh KK, editor. Mitochondrial DNA mutations in aging, disease and cancer. New York: Springer Verlag. p 1-15.
26. Karam LR, Bergtold DS, Simic MG. 1991. Biomarkers of OH radical damage in vivo. Free Radic Res Commun 12-13:11-16.
27. Kasai H, Nishimura S. 1984. Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents. Nucleic Acids Res 12:2137-2145.
28. Kimura Y, Oda S, Egashira A, Kakeji Y, Baba H, Nakabeppu Y, Maehara Y. 2004. A variant form of hMTH1, a human homologue of the E. coli mutT gene, correlates with somatic mutation in the p53 tumour suppressor gene in gastric cancer patients. J Med Genet 41:e57.
29. Kohno T, Sakiyama T, Kunitoh H, Goto K, Nishiwaki Y, Saito D, Hirose H, Eguchi T, Yanagitani N, Saito R, Sasaki-Matsumura R, Mimaki S, Toyama K, Yamamoto S, Kuchiba A, Sobue T, Ohta T, Ohki M, Yokota J. 2006. Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk. Carcinogenesis (in press).