A tertiary twist to the transglutaminase tale

PLoS Biology

Volumn 5, Issue 12, 2007, Pages 2770-2773

  Koning, Frits ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; ENZYME INHIBITOR; HISTOCOMPATIBILITY ANTIGEN;

CELIAC DISEASE; DISEASE COURSE; ENZYME ACTIVATION; HUMAN; REVIEW; ANTIGEN PRESENTING CELL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; IMMUNOLOGY; METABOLISM;

ANTIGEN-PRESENTING CELLS; CELIAC DISEASE; ENZYME INHIBITORS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; TRANSGLUTAMINASES;

EID: 38549112992     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.0050337     Document Type: Review

References (27)

1. Telci G, Griffin M (2006) Tissue transglutaminase (TG2)-a wound response enzyme. Front Biosci 11:867-882.
2. Ruan Q, Johnson GV (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci 12:891-904.
3. Koning F (2005) Celiac disease: caught between a rock and a hard place. Gastroenterology 129: 1294-1301.
4. Sollid LM (2002) Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2: 647-655.
5. Pinkas DM, Strop P, Brunger AT, Khosla C (2007). Transglutaminsase 2 undergoes a large conformational change upon activation. PLoS Biol 5(12): e327. doi:10.1371/journal.pbio.0050327.
6. Lundin KE, Scott H, Hansen T, Paulsen G, Halstensen TS, et al. (1993) Gliadin-specific, HLA-DQ(α1*0501,β1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 178: 187-196.
7. Lundin KA, Scott H, Fausa O, Thorsby E, Sollid LM (1994) T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac-disease patient preferentially recognize gliadin when presented by DQ8. Hum Immunol 41: 285-291.
8. van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, et al. (1998) Small intestinal cells of celiac disease patients recognize a natural pepsin fragment of gliadin. Proc Natl Acad Sci U S A 95: 10050-10054.
9. Vader W, Kooy Y, van Veelen P, de Ru A, Harris D, et al. (2002) The gluten response in children with recent onset celiac disease. A highly diverse response towards multiple gliadin and glutenin derived peptides. Gastroenterology 122: 1729-1737.
10. van de Wal Y, Kooy YMC, Drijfhout JW, Amons R, Koning F (1996) Peptide-binding characteristics of the Coeliac disease associated DQ(a1*0501, ß1*0201) molecule. Immunogenetics 44: 246-253.
11. Johansen BH, Vartdal F, Eriksen JA, Thorsby E, Sollid LM (1996) Identification of a putative motif for binding of peptides to HLA-DQ2. Int Immunol 8: 177-182.
12. Kwok WW, Domeier ME, Raymond FC, Byers P, Nepom GT (1996) Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J Immunol 156: 2171-2177.
13. Molberg Ø, McAdam S, Körner R, Quarsten H, Kristiansen C, et al. (1998) Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut derived T cells in celiac disease. Nat Med 4: 713-717.
14. van de Wal Y, Kooy Y, van Veelen P, Pena S, Mearin L, et al. (1998) Cutting edge: selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 161: 1585-1588.
15. Vader W, de Ru A, van der Wal Y, Kooy Y, Benckhuijsen W, et al. (2002) Specificity of tissue transglutaminase explains cereal toxicity in celiac disease. J Exp Med 195: 643-649.
16. Shan L, Molberg Ø, Parrot I, Hausch F, Filiz F, et al. (2002) Structural basis for gluten intolerance in celiac sprue. Science 297: 2275-2279.
17. Arentz-Hansen H, McAdam SN, Molberg Ø, Fleckenstein B, Lundin KEA, et al. (2002) Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 123: 803-809.
18. Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, et al. (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3: 797-801.
19. Mothes T (2007) Deamidated gliadin peptides as targets for celiac disese-specific antibodies. Adv Clin Chem 44: 35-63.
20. Agardh D (2007) Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol 5:1276-1281.
21. Sollid LM, Molberg Ø, McAdam S, Lundin KEA (1997) Autoantibodies in coeliac disease: tissue transglutaminase-guilt by association? Gut 41: 851-852.
22. Mohan K, Pinto D, Issekutz TB (2003) Identification of tissue transglutaminase as a novel molecule involved in human CD8+ T cell transendothelial migration. J Immunol 171: 3179-3186.
23. Raki M, Schjetne KW, Stamnaes J, Molberg J, Jahnsen FL, et al. (2007) Surface expression of transglutaminase 2 by dendritic cells and its potential role for uptake and presentation of gluten peptides to T cells. Scand J Immunol. 65: 213-220.
24. Maiuri L, Ciacci C, Ricciardelli I, Vacca L, Raia V, et al.(2003) Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 362: 30-37.
25. Hüe S, Mention J-J, Monteiro RC, Zhang SL, Cellier C, et al. (2004) A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 21: 367-377.
26. Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, et al. (2004) Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21: 357-366.
27. Van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, et al.(2007) A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 39: 827-829.