Urotensin II acutely increases myocardial length and distensibility: Potential implications for diastolic function and ventricular remodeling

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 376, Issue 1-2, 2007, Pages 107-115

  Fontes Sousa, Ana Patrícia ^a   Brás Silva, Carmen ^a   Pires, Ana Luísa ^a   Monteiro Sousa, Daniela ^a   Leite Moreira, Adelino F ^a  

^a University of Porto   (Portugal)

Author keywords

Diastolic function; Myocardial distensibility; Myocardial stiffness; NO; Prostaglandins; Urotensin II; UT receptor

Indexed keywords

G PROTEIN COUPLED RECEPTOR; NITRIC OXIDE; PROSTAGLANDIN; UNCLASSIFIED DRUG; UROTENSIN; UROTENSIN II; UTS2R PROTEIN, HUMAN; VASOCONSTRICTOR AGENT;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; DIASTOLE; DRUG ANTAGONISM; DRUG EFFECT; ELASTICITY; HEART CONTRACTION; HEART PAPILLARY MUSCLE; HEART VENTRICLE REMODELING; HUMAN; IN VITRO STUDY; MALE; PHYSIOLOGY; RABBIT;

ANALYSIS OF VARIANCE; ANIMALS; DIASTOLE; ELASTICITY; HUMANS; MALE; MYOCARDIAL CONTRACTION; NITRIC OXIDE; PAPILLARY MUSCLES; PROSTAGLANDINS; RABBITS; RECEPTORS, G-PROTEIN-COUPLED; UROTENSINS; VASOCONSTRICTOR AGENTS; VENTRICULAR REMODELING;

EID: 38449119600     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-007-0180-8     Document Type: Article

References (55)

1. Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Ohlstein EH, Bergsma DJ, Douglas SA (1999) Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature 401:282-286
2. Bern HA, Pearson D, Larson BA, Nishioka RS (1985) Neurohormones from fish tails: the caudal neurosecretory system. I. "Urophysiology" and the caudal neurosecretory system of fishes. Recent Prog Horm Res 41:533-552
3. Bohm F, Pernow J (2002) Urotensin II evokes potent vasoconstriction in humans in vivo. Br J Pharmacol 135:25-27 (Pubitemid 34102094)
4. Borbely A, van der Velden J, Papp Z, Bronzwaer JG, Edes I, Stienen GJ, Paulus WJ (2005) Cardiomyocyte stiffness in diastolic heart failure. Circulation 111: 774-781 (Pubitemid 40250638)
5. Bottrill FE, Douglas SA, Hiley CR, White R (2000) Human urotensin-II is an endothelium-dependent vasodilator in rat small arteries. Br J Pharmacol 130: 1865-1870 (Pubitemid 30655798)
6. Bousette N, Pottinger J, Ramli W, Ohlstein EH, Dhanak D, Douglas SA, Giaid A (2006) Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease. Peptides 11:2919-2926 (Pubitemid 44584417)
7. Brutsaert DL (2003) Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev 83:59-115
8. Brutsaert DL, Meulemans AL, Spido KR, Sys SU (1988) Effects of damaging endocardial surface on the mechanical performance of isolated cardiac muscle. Circ Res 62:358-366 (Pubitemid 18041957)
9. Brutsaert DL, De Keulenaer GW, Fransen P, Mohan P, Kaluza GL, Andries LJ, Rouleau JL, Sys SU (1996) The cardiac endothelium: functional morphology, development, and physiology. Prog Cardiovasc Dis 39:239-262 (Pubitemid 26424610)
10. Camarda V, Rizzi A, Calo G, Gendron G, Perron SI, Kostenis E, Zamboni P, Mascoli F, Regoli D (2002) Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents. Naunyn Schmiedebergs Arch Pharmacol 365:141-149 (Pubitemid 34253107)
11. Conlon JM, Yano K, Waugh D, Hazon N (1996) Distribution and molecular forms of urotensin II and its role in cardiovascular regulation in vertebrates. J Exp Zool 275:226-238 (Pubitemid 26311114)
12. Coulouarn Y, Lihrmann I, Jegou S, Anouar Y, Tostivint H, Beauvillain JC, Conlon JM, Bern HA, Vaudry H (1998) Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci USA 95:15803-15808 (Pubitemid 29018781)
13. Coulouarn Y, Jegou S, Tostivint H, Vaudry H, Lihrmann I (1999) Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett 457:28-32 (Pubitemid 29387403)
14. Douglas SA, Sulpizio AC, Piercy V, Sarau HM, Ames RS, Aiyar NV, Ohlstein EH, Willette RN (2000) Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey. Br J Pharmacol 131:1262-1274
15. Douglas SA, Tayara L, Ohlstein EH, Halawa N, Giaid A (2002) Congestive heart failure and expression of myocardial urotensin II. Lancet 359:1990-1997 (Pubitemid 34663713)
16. Dschietzig T, Bartsch C, Pregla R, Zurbrugg HR, Armbruster FP, Richter C, Laule M, Romeyke E, Neubert C, Voelter W, Baumann G, Stangl K (2002) Plasma levels and cardiovascular gene expression of urotensin-II in human heart failure. Regul Pept 110:33-38 (Pubitemid 35435330)
17. Fontes-Sousa AP, Brás-Silva C, Pires AP, Monteiro-Sousa D, Leite-Moreira AF (2006). Urotensin-II: a novel neurohumoral modulator of diastolic function. Circulation 114:II-315
18. Fukuda N, Wu Y, Nair P, Granzier HL (2005) Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. J Gen Physiol 125:257-271 (Pubitemid 40388308)
19. Gardiner SM, March JE, Kemp PA, Davenport AP, Bennett T (2001) Depressor and regionally-selective vasodilator effects of human and rat urotensin II in conscious rats. Br J Pharmacol 132:1625-629 (Pubitemid 32397953)
20. Gong H, Wang YX, Zhu YZ, Wang WW, Yao T, Zhu YC (2004) Cellular distribution of GPR14 and the positive inotropic role of urotensin II in the myocardium in adult rat. J Appl Physiol 97:2228-2235 (Pubitemid 39552464)
21. Hassan GS, Chouiali F, Saito T, Hu F, Douglas SA, Ao Z, Willette RN, Ohlstein EH, Giais A (2003) Effect of human urotensin-II infusion on hemodynamics and cardiac function. Can J Physiol Pharm 81:125-128 (Pubitemid 36398885)
22. Heymes C, Vanderheyden M, Bronzwaer JG, Shah AM, Paulus WJ (1999) Endomyocardial nitric oxide synthase and left ventricular preload reserve in dilated cardiomyopathy. Circulation 99:3009-3016 (Pubitemid 29270430)
23. Ishihata A, Sakai M, Katano Y (2006) Vascular contractile effect of urotensin II in young and aged rats: influence of aging and contribution of endothelial nitric oxide. Peptides 27:80-86 (Pubitemid 43061040)
24. Ito N, Bartunek J, Spitzer KW, Lorell BH (1997) Effects of the nitric oxide donor sodium nitroprusside on intracellular pH and contraction in hypertrophied myocytes. Circulation 95:2303-2311 (Pubitemid 27191009)
25. Johns DG, Ao Z, Naselsky D, Herold CL, Maniscalco K, Sarov-Blat L, Steplewski K, Aiyar N, Douglas SA (2004) Urotensin-II-mediated cardiomyocyte hypertrophy: effect of receptor antagonism and role of inflammatory mediators. Naunyn Schmiedebergs Arch Pharmacol 370:238-250 (Pubitemid 40063823)
26. Kass DA, Bronzwaer JG, Paulus WJ (2004) What mechanisms underlie diastolic dysfunction in heart failure? Circ Res 94:1533-1542 (Pubitemid 38856960)
27. Leite-Moreira AF (2006) Current perspectives in diastolic dysfunction and diastolic heart failure. Heart 92:712-718
28. Leite-Moreira AF, Bras-Silva C, Pedrosa CA, Rocha-Sousa AA (2003) ET-1 increases distensibility of acutely loaded myocardium: a novel ETA and Na+/H+ exchanger-mediated effect. Am J Physiol Heart Circ Physiol 284:H1332-1339 (Pubitemid 36348597)
29. Leite-Moreira AF, Castro-Chaves P, Pimentel-Nunes P, Lima-Carneiro A, Guerra MS, Soares JB, Ferreira-Martins J (2006) Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect. Br J Pharmacol 147:690-697
30. Li J, Wang J, Russell FD, Molenaar P (2005) Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II. Br J Pharmacol 145:432-440 (Pubitemid 40966272)
31. Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P, George SR, O 'Dwd BF, Docherty JM (1995) Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 29:335-344
32. Massion PB, Feron O, Dessy C, Balligand J-L (2003) Nitric oxide and cardiac function. Ten tears after, and continuing. Circ Res 93:388-398 (Pubitemid 37100003)
33. Matsushita M, Shichiri M, Imai T, Iwashina M, Tanaka H, Takasu N, Hirata Y (2001) Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues. J Hypertens 19:2185-2190 (Pubitemid 33135240)
34. Morimoto A, Hasegawa H, Cheng H -J, Cheng C -P (2002) Urotensin II inhibits left ventricular and myocytes contractile performance and [Ca2+]i transient: normal vs CHF. Circulation 106(Suppl. II): II-26
35. Opgaard OS, Nothacker HP, Ehlert FJ, Krause DN (2000) Human urotensin II mediates vasoconstriction via an increase in inositol phosphates. Eur J Pharmacol 406:265-271
36. Prendergast BD, Sagach VF, Shah AM (1997) Basal release of nitric oxide augments the Frank-Starling response in the isolated heart. Circulation 96:1320-1329 (Pubitemid 27344239)
37. Russell FD (2004) Emerging roles of urotensin-II in cardiovascular disease. Pharmacol Ther 103:223-243
38. Russell FD, Molenaar P (2004) Investigation of signalling pathways that mediate the inotropic effect of urotensin-II in human heart. Cardiovasc Res 63:673-681 (Pubitemid 39078681)
39. Russell FD, Molenaar P, O'Brien DM (2001) Cardiostimulant effects of urotensin-II in human heart in vitro. Br J Pharmacol 132:5-9 (Pubitemid 32128427)
40. Russell FD, Meyers D, Galbraith AJ, Bett N, Toth I, Kearns P, Molenaar P (2003) Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. Am J Physiol Heart Circ Physiol 285:H1576-1581 (Pubitemid 37169512)
41. Sauzeau V, Le Mellionnec E, Bertoglio J, Scalbert E, Pacaud P, Loirand G (2001) Human urotensin II-induced contraction and arterial smooth muscle cell proliferation are mediated by RhoA and Rho-kinase. Circ Res 88:1102-1104 (Pubitemid 34132508)
42. 2+ in intact cardiac myocytes. Circ Res 74:970-978
43. Soares JB, Rocha-Sousa A, Castro-Chaves P, Henriques-Coelho T, Leite-Moreira AF (2006) Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels. Peptides 27:1616-1623 (Pubitemid 43866262)
44. Stirrat A, Gallagher M, Douglas SA, Ohlstein EH, Berry C, Kirk A, Richardson M, MacLean MR (2001) Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries. Am J Physiol Heart Circ Physiol 280:925-928
45. Tal M, Ammar DA, Karpuj M, Krizhanovsky V, Naim M, Thompson DA (1995) A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia. Biochem Biophys Res Commun 209:752-759
46. Tasaki K, Hori M, Ozaki H, Karaki H, Wakabayashi I (2004) Mechanism of human urotensin II-induced contraction in rat aorta. J Pharmacol Sci 94:376-383 (Pubitemid 38590757)
47. Tzanidis A, Hannan RD, Thomas WG, Onan D, Autelitano DJ, See F, Kelly DJ, Gilbert RE, Krum H (2003) Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy. Circ Res 93:246-253 (Pubitemid 36993236)
48. van Heerebeek L, Borbely A, Niessen HW, Bronzwaer JG, van der Velden J, Stienen GJ, Linke WA, Laarman GJ, Paulus WJ (2006) Myocardial structure and function differ in systolic and diastolic heart failure. Circulation 113:1966-1973
49. Wang YX, Ding YJ, Zhu YZ, Shi Y, Yao T, Zhu YC W (2007) Role of PKC in the novel synergistic action of urotensin II and angiotensin II and in urotensin II-induced vasoconstriction. Am J Physiol Heart Circ Physiol 292:H348-H359 (Pubitemid 46105197)
50. Watanabe T, Pakala R, Katagiri T, Benedict CR (2001) Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. Circulation 104:16-18 (Pubitemid 32623283)
51. Watanabe T, Kanome T, Miyazaki A, Katagiri T (2006) Human urotensin II as a link between hypertension and coronary artery disease. Hypertens Res 29:375-387 (Pubitemid 44102804)
52. Weber KT, Sun Y, Guarda E (1994) Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 23:869-877 (Pubitemid 24180829)
53. Wheeler-Jones CP (2005) Cell signalling in the cardiovascular system: an overview. Heart 91:1366-1374
54. Yamamoto K, Masuyama T, Sakata Y, Nishikawa N, Mano T, Yoshida J, Miwa T, Sugawara M, Yamaguchi Y, Ookawara T, Suzuki K, Hori M (2002) Myocardial stiffness is determined by ventricular fibrosis, but not by compensatory or excessive hypertrophy in hypertensive heart. Cardiovasc Res 55:76-82 (Pubitemid 34615941)
55. Yamasaki R, Wu Y, McNabb M, Greaser M, Labeit S, Granzier H (2002) Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes. Circ Res 90:1181-1188 (Pubitemid 34786903)