Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells

Circulation

Volumn 104, Issue 1, 2001, Pages 16-18

  Watanabe, Takuya ^a   Pakala, Rajbabu ^a   Katagiri, Takashi ^b   Benedict, Claude R ^a,c  

^a UNIVERSITY OF TEXAS   (United States)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Hypertension; Lipoproteins; Muscle, smooth; Urotensins

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 HYDROXYNONENAL; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ERBSTATIN; HYDROGEN PEROXIDE; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; OXIDIZED LOW DENSITY LIPOPROTEIN; RADICICOL; REACTIVE OXYGEN METABOLITE; THYMIDINE; UROTENSIN II;

ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CELL PROLIFERATION; DNA SYNTHESIS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; LIPID OXIDATION; PATHOGENESIS; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0035800017     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc2601.092848     Document Type: Article

References (7)

1. Differential vasoconstrictor activity of human urotensin-II in vascular tissue isolated from the rat, mouse, dog, pig, marmoset and cynomolgus monkey
2. Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
3. Contractile response to human urotensin-II in rat and human pulmonary arteries: Effect of endothelial factors and chronic hypoxia in the rat
4. Human urotensin II mediates vasoconstriction via an increase in inositol phosphates
5. Lysophosphatidylcholine and reactive oxygen species mediate the synergistic effect of mildly oxidized LDL with serotonin on vascular smooth muscle cell proliferation
6. Lipid peroxidation product 4-hydroxy-2-nonenal acts synergistically with serotonin in inducing vascular smooth muscle cell proliferation
7. Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice