Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor

Toxicology and Applied Pharmacology

Volumn 212, Issue 3, 2006, Pages 224-236

  Kawakami, Takashige ^a,b   Ishimura, Ryuta ^a   Nohara, Keiko ^a   Takeda, Ken ^b   Tohyama, Chiharu ^a,c   Ohsako, Seiichiroh ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Fetal death; Placenta; Susceptibility; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYCLOPHILIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME INDUCTION; FEMALE; FETUS; FETUS DEATH; FETUS LIVER; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE SEQUENCE; GENE STRUCTURE; GENETIC SUSCEPTIBILITY; HISTOPATHOLOGY; LIVER LEVEL; MALE; MATERNAL BLOOD; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OUTBRED STRAIN; PLACENTA DISORDER; PRENATAL EXPOSURE; PROTEIN INDUCTION; PROTEIN STRUCTURE; RAT; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; TISSUE LEVEL;

ADMINISTRATION, ORAL; ANIMALS; BASE SEQUENCE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DEATH; GENE EXPRESSION PROFILING; GENETIC PREDISPOSITION TO DISEASE; MALE; MOLECULAR SEQUENCE DATA; PLACENTA; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECIES SPECIFICITY; TERATOGENS; TETRACHLORODIBENZODIOXIN;

ANIMALIA;

EID: 33646150439     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.08.007     Document Type: Article

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