Diphtheria toxin mutant CRM197 possesses weak EF2-ADP-ribosyl activity that potentiates its anti-tumorigenic activity

Journal of Biochemistry

Volumn 142, Issue 1, 2007, Pages 95-104

  Kageyama, Takuya ^a,c   Ohishi, Minako ^a   Miyamoto, Shingo ^b   Mizushima, Hiroto ^a   Iwamoto, Ryo ^a   Mekada, Eisuke ^a  

^a OSAKA UNIVERSITY   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

Author keywords

ADP ribosylation; CRM197; Diphtheria toxin; EF 2; HB EGF

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; DIPHTHERIA TOXIN; DIPHTHERIA TOXOID CRM197; ELONGATION FACTOR 2; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MONOCLONAL ANTIBODY; ANTINEOPLASTIC AGENT; BACTERIAL PROTEIN; CRM197 (NON TOXIC VARIANT OF DIPHTHERIA TOXIN); CRM197 (NON-TOXIC VARIANT OF DIPHTHERIA TOXIN); HEPARIN; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; MITOGENIC AGENT; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; CERCOPITHECUS; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; NUDE MOUSE; TUMOR CELL LINE; VERO CELL;

MUS MUSCULUS;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DIPHTHERIA TOXIN; FEMALE; HEPARIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGENS; MUTATION; PEPTIDE ELONGATION FACTOR 2; VERO CELLS;

EID: 38449108178     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvm116     Document Type: Article

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