Aloe-emodin prevents cytokine-induced tumor cell death: The inhibition of auto-toxic nitric oxide release as a potential mechanism

Cellular and Molecular Life Sciences

Volumn 61, Issue 14, 2004, Pages 1805-1815

  Mijatovic, S ^a   Maksimovic Ivanic, D ^a   Radovic, J ^a   Popadic, D ^b   Momcilovic, M ^a   Harhaji, L ^a   Miljkovic, D ^a   Trajkovic, V ^b  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Aloe emodin; iNOS; Nitric oxide; Tumor

Indexed keywords

ALOE EMODIN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BIOACCUMULATION; CANCER INHIBITION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; GENETIC CODE; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PROTEIN INDUCTION; PROTEIN SECRETION; TRANSLATION INITIATION; TUMOR CELL DESTRUCTION;

ALOE; ANIMALIA;

EID: 3843148339     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-004-4089-9     Document Type: Article

References (51)

1. Cifone M. G., Cironi L., Meccia M. A., Roncaioli P., Festuccia C., De Nuntiis G. et al. (1995) Role of nitric oxide in cell-mediated tumor cytotoxicity. Adv. Neroimunol. 5: 443-461
2. MacMicking J., Xie Q. W. and Nathan C. (1997) Nitric oxide and macrophage function. Annu. Rev. Immunol. 15: 323-350
3. Brune B., Knethen A. von and Sandau K. B. (1999) Nitric oxide (NO): an effector of apoptosis. Cell. Death. Differ. 6: 969-975
4. Umansky V. and Schirrmacher V. (2001) Nitric oxide-induced apoptosis in tumor cells. Adv. Cancer Res. 82: 107-131
5. Wei D., Richardson E. L., Zhu K., Wang L., Le X., He Y. et al. (2003) Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase. Cancer Res. 63: 3855-3859
6. Shi Q., Xiong Q., Wang B., Le X., Khan N. A. and Xie K. (2000) Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res. 60: 2579-2583
7. Xie K., Huang S., Dong Z., Juang S. H., Gutman M., Xie Q. W. et al. (1995) Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J. Exp. Med. 181: 1333-1343
8. Juang S. H., Xie K., Xu L., Shi Q., Wang Y., Yoneda J. et al. (1998) Suppression of tumorigenicity and metastasis of human renal carcinoma cells by infection with retroviral vectors harboring the murine inducible nitric oxide synthase gene. Hum. GeneTher. 9: 845-854
9. Hu D. E., Dyke S. O., Moore A. M., Thomsen L. L. and Brindle K. M. (2004) Tumor cell-derived nitric oxide is involved in the immune-rejection of an immunogenic murine lymphoma. Cancer Res. 64: 152-161
10. Jyothi M. D. and Khar A. (2000) Interleukin-2-induced nitric oxide synthase and nuclear factor-κB activity in activated natural killer cells and the production of interferon-γ. Scand. J. Immunol. 52: 148-155
11. Sadanaga N., Nagoshi M., Lederer J. A., Joo H. G., Eberlein T. J. and Goedegebuure P. S. (1999) Local secretion of IFN-γ induces an antitumor response: comparison between T cells plus IL-2 and IFN-γ transfected tumor cells. J. Immunother. 22: 315-323
12. Yu W. G., Yamamoto N., Takenaka H., Mu J., Tai X. G., Zou J. P. et al. (1996) Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12. Int. Immunol. 8: 855-865
13. Hunter S. E., Waldburger K. E., Thibodeaux D. K., Schaub R. G., Goldman S. J. and Leonard J. P. (1997) Immunoregulation by interleukin-12 in MB49.1 tumor-bearing mice: cellular and cytokine-mediated effector mechanisms. Eur. J. Immunol. 27: 3438-3446
14. Hirakawa M., Oike M., Masuda K. and Ito Y. (2002) Tumor cell apoptosis by irradiation-induced nitric oxide production in vascular endothelium. Cancer Res. 62: 1450-1457
15. Manthey C. L., Perera P. Y., Salkowski C. A. and Vogel S. N. (1994) Taxol provides a second signal for murine macrophage tumoricidal activity. J. Immunol. 152: 825-831
16. Son K. and Kim Y. M. (1995) In vivo cisplatin-exposed macrophages increase immunostimulant-induced nitric oxide synthesis for tumor cell killing. Cancer Res. 55: 5524-5527
17. Chen Y., Yang L. and Lee T. J. (2000) Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation. Biochem. Pharmacol. 59: 1445-1457
18. Matsuda H., Kageura T., Morikawa T., Toguchida I., Harima S. and Yoshikawa M. (2000) Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages. Bioorg. Med. Chem. Lett. 10: 323-327
19. Wang C. C., Huang Y. J., Chen L. G., Lee L. T. and Yang L. L. (2002) Inducible nitric oxide synthase inhibitors of Chinese herbs. III. Rheum palmatum. Planta Med. 68: 869-874
20. Goel R. K., Das Gupta G., Ram S. N. and Pandey V. B. (1991) Antiulcerogenic and anti-inflammatory effects of emodin, isolated from Rhamnus triquerta wall. Indian J. Exp. Biol. 29: 230-232
21. Huang H. C., Chu S. H. and Chao P. D. (1991) Vasorelaxants from Chinese herbs, emodin and scoparone, possess immunosuppressive properties. Eur. J. Pharmacol. 198: 211-213
22. Chang C. H., Lin C. C., Yang J. J., Namba T. and Hattori M. (1996) Anti-inflammatory effects of emodin from Ventilago leiocarpa. Am. J. Chin. Med. 24: 139-142
23. Kuo Y. C., Meng H. C. and Tsai W. J. (2001) Regulation of cell proliferation, inflammatory cytokine production and calcium mobilization in primary human T lymphocytes by emodin from Polygonum hypoleucum Ohwi. Inflamm. Res. 50: 73-82
24. Kuo Y. C., Tsai W. J., Meng H. C., Chen W. P., Yang L. Y. and Lin C. Y. (2001) Immune reponses in human mesangial cells regulated by emodin from Polygonum hypoleucum Ohwi. Life Sci. 68: 1271-1286
25. Pechold K., Patterson N. B., Craighead N., Lee K. P., June C. H. and Harlan D. M. (1997) Inflammatory cytokines IFN-γ plus TNF-α induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts. J. Immunol. 158: 4291-4299
26. McCarthy K. D. and De Vellis J. (1980) Preparation of separate astroglia and oligodendroglial cell cultures from rat cerebral tissue. J. Cell. Biol. 85: 890-902
27. Pecere T., Gazzola M. V., Mucignat C., Parolin C., Vecchia F. D., Cavaggioni A. et al. (2000) Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 60: 2800-2804
28. Mosmann T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63
29. Flick D. A. and Gifford G. E. (1984) Comparison of in vitro cell cytotoxic assays for tumor necrosis factor. J. Immunol. Methods 68: 167-175
30. Green L. C., Wagner D. A., Glogowski J., Skipper P. L., Wishnok J. S. and Tannenbaum S. R. (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 126: 131-138
31. Versteeg H. H., Nijhuis E., Van Den Brink G. R., Evertzen M., Pynaert G. N., Van Deventer S. J. et al. (2000) A new phosphospecific cell-based ELISA for p42/p44 mitogen-activated protein kinase (MAPK), p38 MAPK, protein kinase B and cAMP-response-element-binding protein. Biochem. J. 3: 717-722
32. Trajkovic V., Markovic M., Samardzic T., Miljkovic D. J., Popadic D. and Mostarica Stojkovic M. (2001) Amphotericin B potentiates the activation of inducible nitric oxide synthase and causes nitric oxide-dependent mitochondrial dysfunction in cytokine-treated rodent astrocytes. Glia 35: 180-188
33. Miljkovic D., Markovic M., Bogdanovic N., Mostarica Stojkovic M. and Trajkovic V. (2002) Necrotic tumor cells oppositely affect nitric oxide production in tumor cell lines and macrophages. Cell. Immunol. 215: 72-77
34. Misko T. P., Moore W. M., Kasten T. P., Nickols G. A., Corbett J. A., Tilton R. G. et al. (1993) Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233: 119-125
35. Gosh S., May M. and Kopp E. B. (1998) NF-κB and REL proteins: evolutionary conserved mediators of immune responses. Annu. Rev. Immunol.16: 225-260
36. Chan T. C., Chang C. J., Koonchanok N. M. and Geahlen R. L. (1993) Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochem. Biophys. Res. Commun. 193: 1152-1158
37. Zhang L., Chang C. J., Bacus S. S. and Hung M. C. (1995) Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin. Cancer Res. 55: 3890-3896
38. Lee H. Z. (2001) Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. Br. J. Pharmacol. 334: 11-20
39. Kuo P. L., Lin T. C. and Lin C. C. (2002) The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci. 71: 1879-1892
40. Chen Y. C., Shen S. C., Lee W. R., Hsu F. L., Lin H. Y., Ko C. H. et al. (2002) Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem. Pharmacol. 64: 1713-1724
41. Saura M., Zaragoza C., Bao C., McMillan A. and Lowenstein C. J. (1999) Interaction of interferon regulatory factor-1 and nuclear factor-κB during activation of inducible nitric oxide synthase transcription. J. Mol. Biol. 289: 459-471
42. Kumar A., Dhawan S. and Aggarwal B. B. (1998) Emodin (3-methyl-1,6,8- trihydroxyanthraquinone) inhibits TNF-induced NF-κB activation, IκB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 17: 913-918
43. Jayasuriya H., Koonchanok N. M., Geahlen R. L., McLaughlin J. L. and Chang C. J. (1992) Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J. Nat. Prod. 55: 696-698
44. Dell'Albani P., Santangelo R., Torrisi L., Nicoletti V. G., Vellis J. de and Giuffrida Stella A. M. (2001) JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. J. Neurosci Res. 65: 417-424
45. Samardzic T., Jankovic V., Stosic-Grujicic S. and Trajkovic V. (2001) STAT1 is required for iNOS activation, but not IL-6 production in murine fibroblasts. Cytokine 13: 179-182
46. Chen C. W., Chang Y. H., Tsi C. J. and Lin W. W. (2003) Inhibition of IFN-γ-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway. J. Immunol. 171: 979-988
47. Barber S. A., Fultz M. J., Salkowski C. A. and Vogel S. N. (1995) Differential expression of interferon regulatory factor 1 (IRF-1), IRF-2, and interferon consensus sequence binding protein genes in lipopolysaccharide (LPS)-responsive and LPS-hyporesponsive macrophages. Infect. Immun. 63: 601-608
48. Konopka T. E., Barker J. E., Bamford T. L., Guida E., Anderson R. L. and Stewart A. G. (2001) Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. Cancer Res. 61: 3182-3187
49. Cianchi F., Cortesini C., Fantappie O., Messerini L., Schiavone N., Vannacci A. et al. (2003) Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis. Am. J. Pathol. 162: 793-801
50. Feinstein D. L., Galea E., Roberts S., Berquist H., Wang H. and Reis D. J. (1994) Induction of nitric oxide synthase in rat C6 glioma cells. J. Neurochem. 62: 315-321
51. Samardzic T., Stosic-Grujicic S., Maksimovic D., Jankovic V. and Trajkovic V. (2000) Differential regulation of nitric oxide production by increase of intracellular cAMP in murine primary fibroblasts and L929 fibrosarcoma cell line. Immunol. Lett. 71: 149-155