Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthase

Cancer Research

Volumn 63, Issue 14, 2003, Pages 3855-3859

  Wei, Daoyan ^a   Richardson, Erica L ^a,b   Zhu, Keyi ^a,b   Wang, Liwei ^a   Le, Xiangdong ^a   He, Yanjuan ^a   Huang, Suyun ^a   Xie, Keping ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; HOST CELL; LUNG METASTASIS; METASTASIS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOUTHERN BLOTTING; TUMOR CELL LINE; TUMOR GROWTH; WESTERN BLOTTING;

ANIMALS; CELL DIVISION; FEMALE; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; TUMOR CELLS, CULTURED;

EID: 0041742276     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Xie, K., and Huang, S. Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiency. Free Radic. Biol. Med., 34: 969-986, 2003.
2. Ambs, S., Hussain, S. P., and Harris, C. C. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. J., 11: 443-448, 1997.
3. Fukumura, D., and Jain, R. K. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Rev., 17: 77-89, 1998.
4. Lala, P. K., and Orucevic, A. Role of nitric oxide in tumor progression: lessons from experimental tumors. Cancer Metastasis Rev., 17: 91-106, 1998.
5. Wink, D. A., Vodovotz, Y., Laval, J., Laval, F., Dewhirst, M. W., and Mitchel, J. B. The multifaceted roles of nitric oxide in cancer. Carcinogenesis (Lond.), 19: 711-721, 1998.
6. Xie, K., and Huang, S. Regulation of cancer metastasis by stress pathways. Clin. Exp. Metastasis, 20: 31-43, 2003.
7. Nathan, C. Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling. J. Clin. Investig., 111: 769-778, 2003.
8. Moncada, S. Nitric oxide: discovery and impact on clinical medicine. J. R. Soc. Med., 92: 164-169, 1999.
9. Jaffrey, S. R., and Snyder, S. H. Nitric oxide: a neural messenger. Annu. Rev. Cell Dev. Biol., 11: 417-440, 1995.
10. Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., and Chaudhuri, G. Endothelial-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA, 84: 9265-9269, 1987.
11. Xie, K., Huang, S., Gutman, M., and Fidler, I. J. Direct correlation between expression of endogenous nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastasis in mice treated with liposomes containing lipopeptide CGP 31362. Cancer Res., 55: 3123-3131, 1995.
12. Farrar, M. A., and Schreiber, R. D. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol., 11: 571-611, 1993.
13. Wang, B., Xiong, Q., Shi, Q., Le, X., and Xie, K. Genetic disruption of host interferon-γ drastically enhanced the metastasis of pancreatic adenocarcinoma through impaired expression of inducible nitric oxide synthase. Oncogene, 20: 6930-6937, 2001.
14. Shi, Q., Wang, B., Xiong, Q., Le, X., Khan, N., and Xie, K. Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res., 60: 2645-2650, 2000.
15. Laubach, V. E., Shesely, E. G., Smithies, O., and Sherman, P. A. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA, 92: 10688-10692, 1995.
16. MacMicking, J. D., Nathan, C., Hom, G., Chartrain, N., Fletcher, D. S., Trumbauer, M., Stevens, K., Xie, Q. W., Sokol, K., Hutchinson, N., and et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell, 81: 641-650, 1995.
17. Wang, B., Xiong, Q., Shi, Q., Le, X., Abbruzzese, J. L., Khan, N., and Xie, K. Intact nitric oxide synthase II gene is required for interferon-β-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. Cancer Res., 61: 71-75, 2001.
18. Zhang, X. M., and Xu, Q. Metastatic melanoma cells escape from immunosurveillance through the novel mechanism of releasing nitric oxide to induce dysfunction of immunocytes. Melanoma Res., 11: 559-567, 2001.
19. Wang, H. H., McIntosh, A. R., Hasinoff, B. B., MacNeil, B., Rector, E., Nance, D. M., and Orr, F. W. Regulation of B16F1 melanoma cell metastasis by inducible functions of the hepatic microvasculature. Eur. J. Cancer, 38: 1261-1270, 2002.
20. Wang, B., Wei, D., Crum, V. E., Richardson, E. L., Xiong, H. Q., Luo, Y., Huang, S., Abbruzzese, J. L., and Xie, K. A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. Oncogene, 22: 319-329, 2003.