CYFIP2 is highly abundant in CD4+ cells from multiple sclerosis patients and is involved in T cell adhesion

European Journal of Immunology

Volumn 34, Issue 4, 2004, Pages 1217-1227

  Mayne, Michael ^a,b   Moffat, Teri ^a   Kong, Hong ^a   McLaren, Paul J ^a   Fowke, Keith R ^a   Becker, Kevin G ^c   Namaka, Mike ^a   Schenck, Annette ^d   Bardoni, Barbara ^d   Bernstein, Charles N ^a   Melanson, Maria ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c NATIONAL INSTITUTE ON AGING   (United States)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Adhesion molecules and signal transduction; Human; Multiple sclerosis; T lymphocytes

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; BINDING PROTEIN; CD4 ANTIGEN; FIBRONECTIN; PROTEIN CYFIP2; RAC1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN;

ARTICLE; BLOOD SAMPLING; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; ENTERITIS; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; T LYMPHOCYTE; WESTERN BLOTTING; ADULT; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION; IMMUNOLOGY; LEUKEMIA CELL LINE; MALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADULT; BLOTTING, WESTERN; CARRIER PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATORY BOWEL DISEASES; JURKAT CELLS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 3843144127     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324726     Document Type: Article

References (41)

1. Ffrench-Constant, C., Pathogenesis of Multiple Sclerosis. Lancet 1994. 343: 271-275.
2. Lassmann, H., Classification of demyelinating diseases at the interface between etiology and pathogenesis. Curr. Opin. Neurol. 2001. 14: 253-258.
3. + T cells in cerebrospinal fluid from multiple sclerosis patients. Brain 2002. 125: 538-550.
4. Franklin, R. J., Why does remyelination fail in multiple sclerosis? Nat. Rev. Neurosci. 2002. 3: 705-714.
5. Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E., Garren, H., Langer-Gould, A., Strober, S., Cannella, B., Allard, J., Klonowski, P., Austin, A., Lad, N., Kaminski, N., Galli, S. J., Oksenberg, J. R., Raine, C. S., Heller, R. and Steinman, L., Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002. 8: 500-508.
6. Whitney, L. W., Ludwin, S. K., McFarland, H. F. and Biddison, W. E., Microarray analysis of gene expression in multiple sclerosis and EAE identifies 5-lipoxygenase as a component of inflammatory lesions. J. Neuroimmunol. 2001. 121: 40-48.
7. Whitney, L. W., Becker, K. G., Tresser, N. J., Caballero-Ramos, C. I., Munson, P. J., Prabhu, V. V., Trent, J. M., McFarland, H. F. and Biddison, W. E., Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann. Neurol. 1999. 46: 425-428.
8. Schenck, A., Bardoni, B., Moro, A., Bagni, C. and Mandel, J. L., A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc. Natl. Acad. Sci. USA 2001. 98: 8844-8849.
9. Ng, J., Nardine, T., Harms, M., Tzu, J., Goldstein, A., Sun, Y., Dietzl, G., Dickson, B. J. and Luo, L., Rac GTPases control axon growth, guidance and branching. Nature 2002. 416: 442-447.
10. Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M. and Kirschner, M. W., Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 2002. 418: 790-793.
11. Ransohoff, R. M., Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines. J. Neuroimmunol. 1999. 98: 57-68.
12. Poggi, A., Zocchi, M. R., Carosio, R., Ferrero, E., Angelini, D. F., Galgani, S., Caramia, M. D., Bernardi, G., Borsellino, G. and Battistini, L., Transendothelial migratory pathways of Vdelta1(+)TCRgammadelta(+) and Vdelta2(+)TCRgammadelta(+) T lymphocytes from healthy donors and multiple sclerosis patients: involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II. J. Immunol. 2002. 168: 6071-6077.
13. Gomez, M., Tybulewicz, V. and Cantrell, D. A., Control of pre-T cell proliferation and differentiation by the GTPase Rac-I. Nat. Immunol. 2000. 1: 348-352.
14. Racke, M. K., Ratts, R. B., Arredondo, L., Perrin, P. J. and Lovett-Racke, A., The role of costimulation in autoimmune demyelination. J. Neuroimmunol. 2000. 107: 205-215.
15. Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V., Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 1997. 390: 632-636.
16. Karussis, D., Abramsky, O., Grigoriadis, N., Chapman, J., Mizrachi-Koll, R., Niv, H. and Kloog, Y., The Ras-pathway inhibitor, S-trans-trans-farnesylthiosalicylic acid, suppresses experimental allergic encephalomyelitis. J. Neuroimmunol. 2001. 120: 1-9.
17. Mayne, M., Cheadle, C., Soldan, S. S., Cermelli, C., Yamano, Y., Akhyani, N., Nagel, J. E., Taub, D. D., Becker, K. G. and Jacobson, S., Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J. Virol. 2001. 75: 11641-11650.
18. Martino, G., Grohovaz, F., Brambilla, E., Codazzi, F., Consiglio, A., Clementi, E., Filippi, M., Comi, G. and Grimaldi, L. M., Proinflammatory cytokines regulate antigen-independent T cell activation by two separate calcium-signaling pathways in multiple sclerosis patients. Ann. Neurol. 1998. 43: 340-349.
19. Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J. L. and Giangrande, A., CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron 2003. 38: 887-898.
20. Milner, R. and Campbell, I. L., The integrin family of cell adhesion molecules has multiple functions within the CNS. J. Neurosci. Res. 2002. 69: 286-291.
21. Tubridy, N., Behan, P. O., Capildeo, R., Chaudhuri, A., Forbes, R., Hawkins, C. P., Hughes, R. A., Palace, J., Sharrack, B., Swingler, R., Young, C., Moseley, I. F., MacManus, D. G., Donoghue, S. and Miller, D. H., The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology 1999. 53: 466-472.
22. Miller, D. H., Khan, O. A., Sheremata, W. A., Blumhardt, L. D., Rice, G. P., Libonati, M. A., Willmer-Hulme, A. J., Dalton, C. M., Miszkiel, K. A. and O'Connor, P. W., A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 2003. 348: 15-23.
23. Jensen, J., Krakauer, M. and Sellebjerg, F., Increased T cell expression of CD154 (CD40-ligand) in multiple sclerosis. Eur. J. Neurol. 2001. 8: 321-328.
24. Huang, W. X., Huang, P. and Hillert, J., Systemic upregulation of CD40 and CD40 ligand mRNA expression in multiple sclerosis. Mult. Scler 2000. 6: 61-65.
25. Laman, J. D., t' Hart, B. A., Brok, H., Meurs, M., Schellekens, M. M., Kasran, A., Boon, L., Bauer, J., Boer, M. and Ceuppens, J., Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12). Eur. J. Immunol. 2002. 32: 2218-2228.
26. Balashov, K. E., Rottman, J. B., Weiner, H. L. and Hancock, W. W., CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 1999. 96: 6873-6878.
27. Teleshova, N., Pashenkov, M., Huang, Y. M., Soderstrom, M., Kivisakk, P., Kostulas, V., Haglund, M. and Link, H., Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid. J. Neurol. 2002. 249: 723-729.
28. Murzenok, P. P., Matusevicius, D. and Freedman, M. S., gamma/delta T cells in multiple sclerosis: chemokine and chemokine receptor expression. Clin. Immunol. 2002. 103: 309-316.
29. + myelin peptide-specific T cells: importance of IFN-inducible protein 10. J. Immunol. 1998. 160: 444-448.
30. Prat, A., Biernacki, K., Lavoie, J. F., Poirier, J., Duquette, P. and Antel, J. P., Migration of multiple sclerosis lymphocytes through brain endothelium. Arch. Neurol. 2002. 59: 391-397.
31. + T cells from acute multiple sclerosis patients display selective increase of adhesiveness in brain venules: a critical role for P- selectin glycoprotein ligand-1. Blood 2003. 20: 4775-4782.
32. Giunti, D., Borsellino, G., Benelli, R., Marchese, M., Capello, E., Valle, M. T., Pedemonte, E., Noonan, D., Albini, A., Bernardi, G., Mancardi, G. L., Battistini, L. and Uccelli, A., Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J. Leukoc. Biol. 2003. 73: 584-590.
33. Campbell, J. J., Murphy, K. E., Kunkel, E. J., Brightling, C. E., Soler, D., Shen, Z., Boisvert, J., Greenberg, H. B., Vierra, M. A., Goodman, S. B., Genovese, M. C., Wardlaw, A. J., Butcher, E. C. and Wu, L., CCR7 expression and memory T cell diversity in humans. J. Immunol. 2001. 166: 877-884.
34. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G. and Iwatsubo, T., The role of presenilin cofactors in the gamma-secretase complex. Nature 2003. 422: 438-441.
35. Cantrell, D., Lymphocyte signalling: a coordinating role for Vav? Curr. Biol. 1998. 8: R535-538.
36. Chiang, Y. J., Kole, H. K., Brown, K., Naramura, M., Fukuhara, S., Hu, R. J., Jang, I. K., Gutkind, J. S., Shevach, E. and Gu, H., Cbl-b regulates the CD28 dependence of T cell activation. Nature 2000. 403: 216-220.
37. Hyduk, S. J. and Cybulsky, M. I., Alpha 4 integrin signaling activates phosphatidylinositol 3-kinase and stimulates T cell adhesion to intercellular adhesion molecule-1 to a similar extent as CD3, but induces a distinct rearrangement of the actin cytoskeleton. J. Immunol. 2002. 168: 696-704.
38. Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, M. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H. and Tourtellotte, W. W., New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 1983. 13: 227-231.
39. Eisen, M. B., Spellman, P. T., Brown, P. O. and Botstein, D., Cluster analysis and display of genome-wide expression patterns. Proc. Natl. Acad. Sci. USA 1998. 95: 14863-14868.
40. Mayne, M., Ni, W., McKenna, R. and Power, C., Antisense oligodeoxynucleotides targeting internal exon sequences efficiently regulate TNF-alpha expression. Antisense Nucleic Acid Drug Dev. 1999. 9: 135-144.
41. Chen, Z., Ahonen, M., Hamalainen, H., Bergelson, J. M., Kahari, V. M. and Lahesmaa, R., High-efficiency gene transfer to primary T lymphocytes by recombinant adenovirus vectors. J. Immunol. Methods 2002. 260: 79-89.