Astrocytic cytochromes p450: An enzyme subfamily critical for brain metabolism and neuroprotection;Les cytochromes P450 astrocytaires, une famille d'enzymes clés dans le métabolisme cérébral et la neuroprotection

Revue Neurologique

Volumn 160, Issue 6-7, 2004, Pages 651-658

  Malaplate Armand, C ^a   Leininger Muller, B ^a   Batt, A M ^a  

^a INSERM   (France)

Author keywords

Astrocytes; Brain metabolism; Cytochromes P450; Neuroprotection; Neurotoxicity

Indexed keywords

AMITRIPTYLINE; CARBAMAZEPINE; CLOMIPRAMINE; COCAINE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 27B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2C11; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 3A4; CYTOCHROME P450 4A; CYTOCHROME P450 4A11; DISULFIRAM; FLUOXETINE; FLUVOXAMINE; HALOPERIDOL; ISONIAZID; PAROXETINE; PERPHENAZINE; PHENOBARBITAL; PHENYTOIN; SERTRALINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

ASTROCYTE; BIOTRANSFORMATION; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN METABOLISM; CATALYSIS; ENZYME REGULATION; HUMAN; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; REVIEW; STEROIDOGENESIS; XENOBIOTIC METABOLISM;

EID: 3843133950     PISSN: 00353787     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0035-3787(04)71014-0     Document Type: Review

References (49)

1. ALEXANDER JJ, SNYDER A, TONSGARD JH. (1998). Omega-oxidation of monocarboxylic acids in rat brain. Neurochem Res, 23: 227-233.
2. ALKAYED NJ, NARAYANAN J, GEBREMEDHIN D, MEDHORA M, ROMAN RJ, HARDER DR. (1996). Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes. Stroke, 27:971-979.
3. AMRUTHESH SC, BOERSCHEL MF, MCKINNEY JS, WILLOUGHBY KA, ELLIS EF. (1993). Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes. J Neurochem, 61: 150-159.
4. BAULIEU EE. (1998). Neurosteroids: a novel function of the brain. Psychoneuroendocrinology, 23: 963-987.
5. BROWN RC, CASCIO C, PAPADOPOULOS V. (2000). Pathways of neurosteroid biosynthesis in cell lines from human brain: regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide. J Neurochem, 74: 847-859.
6. COHEN Z, BONVENTO G, LACOMBE P, HAMEL E. (1996). Serotonin in the regulation of brain microcirculation. Prog Neurobiol, 50: 335-362.
7. DONG Y, BENVENISTE EN. (2001). Immune function of astrocytes. Glia, 36: 180-190.
8. EARLEY S, PASTUSZYN A, WALKER BR. (2003). Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia. Am J Physiol Heart Circ Physiol, 285: H127-136.
9. ENG LF, GHIRNIKAR RS, LEE YL. (2000). Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res, 25: 1439-1451.
10. FARIN FM, OMIECINSKI CJ. (1993). Regiospecific expression of Cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. J Toxicol Environ Health, 40: 317-335.
11. FIELDS RD, STEVENS-GRAHAM B. (2002). New insights into neuronglia communication. Science, 298: 556-562.
12. FISSLTHALER B, Popp R, Kiss L, POTENTE M, HARDER DR, FLEMING I, BUSSE R. (1999). Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature, 401: 493-497.
13. FLEMING I, MICHAELIS UR, BREDENKOTTER D, FISSLTHALER B, DEHGHANI F, BRANDES RP, BUSSE R. (2001). Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res, 88: 44-51.
14. FRISBEE JC, ROMAN RJ, KRISHNA UM, FALCK JR, LOMBARD JH. (2001). Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. J Vasc Res, 38: 305-314.
15. GARCIA-ESTRADA J, LUQUIN S, FERNANDEZ AM, GARCIA-SEGURA LM. (1999). Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury. Int J Dev Neurosci, 17: 145-151.
16. GARCIA-SEGURA LM, WOZNIAK A, AZCOITIA I, RODRIGUEZ JR, HUTCHISON RE, HUTCHISON JB. (1999). Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repair. Neuroscience, 89: 567-578.
17. GHERSI-EGEA JF, LIVERTOUX MH, MINN A, PERRIN R, SIEST G. (1991). Enzyme mediated superoxide radical formation initiated by exogenous molecules in rat brain preparations. Toxicol Appl Pharmacol, 110: 107-117.
18. HARDER DR, ROMAN RJ, GEBREMEDHIN D. (2000). Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. Acta Physiol Scand, 168: 543-549.
19. HAYASHI Y, NOMURA M, YAMAGISHI S, HARADA S, YAMASHITA J, YAMAMOTO H. (1997). Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes. Glia, 19: 13-26.
20. HOSLI E, HOSLI L. (1993). Receptors for neurotransmitters on astrocytes in the mammalian central nervous system. Prog neurobiol, 40: 477-506.
21. HOWARDS LA, SELLERS EM, TYNDALE RF. (2002). The role of pharmacogenetically-variable cytochrome P450 enzymes in dependence. Pharmacogenetics, 3: 185-199.
22. JANZER RC, RAFF MC. (1987). Astrocytes induce blood-brain barrier properties in endothelial cells. Nature, 325: 253-257.
23. KAPITULNIK J, STROBEL HW. (1999). Extrahepatic drug metabolizing enzymes. J Biochem Mol Toxicol, 13: 227-230.
24. KLOSE TXS, BLAISDELL JA, GOLDSTEIN JA. (1999). Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J Biochem Mol Toxicol, 13: 289-295.
25. KNUPFER H, KNUPFER MM, HOTFILDER M, PREISS R. (1999). P450-expression in brain tumors. Oncol Res, 11: 523-528.
26. LANGE A, GEBREMEDHIN D, NARAYANAN J, HARDER D. (1997). 20-Hydroxyeicosatetraenoic acid-induced vasoconstriction and inhibition of potassium current in cerebral vascular smooth muscle is dependent on activation of protein kinase C. J Biol Chem, 272: 27345-27352.
27. LEININGER B, GHERSI-EGEA JF, SIEST G, MINN A. (1991). In vivo study of the elimination from rat brain of an intracerebrally formed xenobiotic metabolite, 1-naphtyl-beta-D-glucuronide. J Neurochem, 56: 1163-1168.
28. MAAS RM, REUS K, DIESEL B, STEUDEL WI, FEIDEN WI, FISCHER U, MEESE E. (2001). Amplification and expression of splice variants of the gene encoding the P450 cytochrome 25-hydroxyvitamin D(3) 1, alpha-hydroxylase (CYP27B1) in human malignant glioma. Clin Cancer Res, 7: 868-875.
29. MALAPLATE-ARMAND C, FERRARI L, MASSON C, SIEST G, BATT AM. (2003). Astroglial CYP1B1 up-regulation in inflammatory/oxidative toxic conditions: IL-1 beta effect and protection by N-acetylcysteine. Toxicol lett, 138: 243-251.
30. MALATESTA P, HARTFUSS E, GOTZ M. (2000). Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage. Development, 127: 5253-52693.
31. MARIN P, STELLA N, CORDIER J, GLOWINSKI J, PREMONT J. (1993). Role of arachidonic acid and glutamate in the formation of inositol phosphates induced by noradrenalin in striatal astrocytes. Mol Pharmacol, 44: 1176-1184.
32. MEYER RP, KNOTH R, SCHILTZ E, VOLK B. (2001). Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary culture. Exp Neurol, 167: 376-384.
33. NITHIPATIKOM K, GRALL AJ, HOLMES BB, HARDER DR, FALCK JR, CAMPBELL WB. (2001). Liquid chromatographic-electrospray ionisation-mass spectrometric analysis of cytochrome P450 metabolites of arachidonic acid. Anal Biochem, 298: 327-336.
34. OLIET SH, PIET R, POULAIN DA. (2001). Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science, 292: 923-926.
35. PORTER JT, MCCARTHY KD. (1997). Astrocytic neurotransmitter receptors in situ and in vivo. Prog Neurobiol, 51: 439-455.
36. RAVINDRANATH V. (1998). Metabolism of xenobiotics in the central nervous system: implications and challenges. Biochem Pharmacol, 56: 547-551.
37. RIDER JL, MALHOTRA SK, PRIVAT A, GAGE FH. (1997). Reactive astrocytes: cellular and molecular cues to biological functions. Trends neurosci, 20: 570-577.
38. RIEDER CR, PARSONS RB, FITCH NJ, WILLIAMS AC, RAMSDEN DB. (2000). Human brain cytochrome P450 1B1: immunohistochemical localization in human temporal lobe and induction by dimethylbenz(a)anthracene in astrocytoma cell line (MOG-GCCM). Neurosci Lett, 278: 177-180.
39. RUPPRECHT R, HOLSBOER F. (1999). Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci, 22: 410-416.
40. RZIGALINSKI BA, WILLOUGHBY KA, HUFFMAN SW, FALCK JR, ELLIS EF. (1999). Calcium influx factor, further evidence it is 5,6-epoxyeicosatrienoic acid. J Biol Chem, 274: 175-182.
41. SIEGLE I, FRITZ P, ECKHARDT K, ZANGER UM, EICHELBAUM M. (2001). Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics, 11: 237-245.
42. SONG H, STEVENS CF, GAGE FH. (2002). Astroglia induce neurogenesis drom adult neural stem cells. Nature, 417: 39-44.
43. STOFFEL-WAGNER B. (2001). Neurosteroid metabolism in the human brain. Eur J Endocrinol, 145: 669-679.
44. STROBEL HW, THOMPSON CM, ANTONOVIC L. (2001). Cytochromes P450 in brain: function and significance. Curr Drug Metab, 2: 199-214.
45. TINDBERG N, BADWIN HA, CROSS AJ, INGELMAN-SUNDBERG M. (1996). Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury. Mol Pharmacol, 50: 1065-1072.
46. ULLIAN EM, SAPPERSTEIN SK, CHRISTOPHERSON KS, BARRES BA. (2001). Control of synapse number by glia. Science, 291: 657-661.
47. WILSON JX. (1997). Antioxidant defense of the brain:a role for astrocytes. Can J Physiol Pharmacol, 75: 1149-1163.
48. YANG B, GRAHAM L, DIKALOV S, MASON RP, FALCK JR, LIAO JK, ZELOIN DC. (2001). Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. Mol Pharmacol, 60: 310-320.
49. ZWAIN IH, YEN SS, CHENG CY. (1997). Astrocytes cultured in vitro produced estradiol-17beta and express aromatase cytochrome P450 (P450) AROM) mRNA. Biochem Biophys Acta, 1130: 338-348.