Pregnancy-induced hyperphagia is associated with increased gene expression of hypothalamic agouti-related peptide in rats

Regulatory Peptides

Volumn 114, Issue 2-3, 2003, Pages 159-165

  Rocha, Milagros ^a   Bing, Chen ^b   Williams, Gareth ^b   Puerta, Marisa ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Energy balance; Hypothalamus; Long form of leptin receptor; Melanocortins; Neuropeptide Y; Orexins

Indexed keywords

AGOUTI RELATED PROTEIN; ANOREXIGENIC AGENT; APPETITE STIMULANT; BRAIN PROTEIN; FAT; LEPTIN; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; NEUROPEPTIDE Y; OREXIN; OREXIN A; OREXIN B; PROOPIOMELANOCORTIN;

ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; CONTROLLED STUDY; ENERGY BALANCE; FAT INTAKE; FEMALE; FOOD INTAKE; GENE EXPRESSION; GESTATION PERIOD; HYPERPHAGIA; LIPID STORAGE; NERVE TRACT; NONHUMAN; PEPTIDE ANALYSIS; PREGNANCY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN SECRETION; RAT;

AGOUTI; ANIMALIA; RATTUS NORVEGICUS;

EID: 0038464727     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(03)00119-8     Document Type: Article

References (48)

1. Abelenda M., Puerta M. Inhibition of diet-induced thermogenesis during pregnancy in the rat. Pflügers Arch. 409:1987;314-317.
2. Flynn M.C., Plata-Salaman C.R., Ffench-Mullen J.M. Neuropeptide Y-related compounds and feeding. Physiol. Behav. 65:1999;901-905.
3. Kalra S.P., Dube M.G., Fournier A., Kalra P.S. Structure-function analysis of stimulation of food intake by neuropeptide Y: effects of receptor agonists. Physiol. Behav. 50:1991;5-9.
4. Stanley B.G., Leibowitz S.F. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proc. Natl. Acad. Sci. U. S. A. 82:1985;3940-3943.
5. Mercer J.G., Hoggard N., Williams L.M., Lawrence C.B., Hannah L.T., Morgan P.J.et al. Coexpression of leptin receptor and preproneuropeptide Y mRNA in ARC of mouse hypothalamus. J. Neuroendocrinol. 8:1996;733-735.
6. Baskin D.G., Schwartz M.W., Seeley R.J., Woods S.C., Porte D., Breininger J.F.et al. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J. Histochem. Cytochem. 47:1999;353-362.
7. Stephens T.W., Basinski M., Bristow P.K., Bue-Valleskey J.M., Burgett S.G., Craft L.et al. The role of neuropeptide Y in the antiobesity actions of the gene product. Nature. 377:1995;530-532.
8. Wang Q., Bing C., Al-Baranzanji K., Mooskowaska D.E., Wang X.-M., McBay D.L.et al. Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes. 46:1997;335-341.
9. Fan W., Boston B., Kesterson R., Hruby V., Cone R. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
10. Grill H.J., Ginsberg A.B., Seeley R.J., Kaplan J.M. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J. Neurosci. 18:1998;10128-10135.
11. Cheung C.C., Clifton D.K., Steiner R.A. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology. 138:1997;4489-4492.
12. Cowley M.A., Smart J.L., Rubinstein M., Cerdán M.G., Diano S., Horvath T.L.et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484.
13. Schwartz M.W., Seeley R.J., Woods S.C., Weigle D.S., Campfield L.A., Burn P.et al. Leptin increases hypothalamic proopiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes. 46:1997;2119-2123.
14. Broberger C., Johansen J., Johansson C., Schalling M., Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15043-15048.
15. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I.et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:1997;135-138. [published erratum appears in Science 1998, Sep 11;281 (5383):1615].
16. Dagerlind A., Friberg K., Bean A., Hokfelt T. Sensitive mRNA detection using unfixed tissue: combined radioactive and non-radioactive in situ hybrid biochemistry. Histochemistry. 98:1992;39-49.
17. 1 receptor like immunoreactivy exists in a sub population of beta-endorphin inmunoreactive nerve cells in the arcuate nucleus: a double immunolabelling analysis in the rat. Neurosci. Lett. 225:1997;49-52.
18. Bagnol D., Lu X.-Y., Kaelin C.B., Day H.E.W., Ollman M., Gantz I.et al. Anatomy of an endogenous antagonist: relationship between agouti-related protein and proopiomelanocortin in brain. J. Neurosci. 19(1-7):1999;. [RC26].
19. Peyron C., Tighe D.K., van del Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G.et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:1998;9996-10015.
20. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H.et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 192:1998;573-585.
21. Sweet D.C., Levine A.S., Billington C.J., Kotz C.M. Feeding response to central orexins. Brain Res. 821:1999;535-538.
22. Edwards C.B., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 160:1999;R7-R12.
23. Håkansson M., de Lecea L., Sutcliffe J.G., Yanagisawa M., Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. J. Neuroendocrinol. 11:1999;653-663.
24. Amico J.A., Thomas A., Crowley R.S., Burmeister L.A. Concentrations of leptin in the serum of pregnant, lactating, and cycling rats of leptin messenger ribonucleic acid in rat placental tissue. Life Sci. 63:1998;1387-1395.
25. Chien E.K., Hara M., Rouard M., Yano H., Phillippe M., Polonsky K.S.et al. Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. Biochem. Biophys. Res. Commun. 237:1997;476-480.
26. García M.C., Casanueva F.F., Diéguez C., Señaris R.M. Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biol. Reprod. 62:2000;698-703.
27. Williams G., Gill J.S., Lee Y.C., Cardoso H.M., Okpere B.E., Bloom S.R. Increased neuropeptide Y concentrations in specific hypothalamic regions of streptozotocin-induced diabetic rats. Diabetes. 38:1989;321-327.
28. Nava M.P., Abelenda M., Puerta M. Cold-induced and diet-induced thermogenesis in progesterone treated rats. Pflügers Arch. 415:1990;747-750.
29. Ahima R.S., Flier J.S. Leptin. Annu. Rev. Physiol. 62:2000;413-437.
30. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D.et al. Weight reducing effects of the plasma protein encoded by the obese gen. Science. 269:1995;543-546.
31. Mann P.E., Rubin B.S., Bridges R.S. Differential proopiomelanocortin gene expression in the medial basal hypothalamus of rats during pregnancy and lactation. Mol. Brain Res. 46:1997;9-16.
32. Blake A.D., Bot G., Li S., Freeman J.C., Reisine T. Differential agonist regulation of the human kappa-opioid receptor. J. Neurochem. 68:1997;1846-1852.
33. Shockley M.S., Burford N.T., Sadee W., Lameh J. Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. J. Neurochem. 68:1997;601-609.
34. Ciofi P., Fallon J.H., Croix D., Polak J.M., Tramu G. Expression of neuropeptide Y precursor-immunoreactivity in the hypothalamic dopaminergic tubero-infundibular system during lactation in rodents. Endocrinology. 128:1991;823-834.
35. Wilding J.P.L., Ajala M.O., Lambert P.D., Bloom S.R. Additive effects of lactation and food restriction to increase hypothalamic neuropetide Y mRNA in rats. J. Endocrinol. 152:1997;365-369.
36. Chen P., Li C., Haskell-Luevano C., Cone R.D., Smith M.S. Altered expression of agouti-related protein and its colocalization with neuropeptide Y in the arcuate nucleus of the hypothalamus during lactation. Endocrinology. 140:1999;2645-2650.
37. Hahn T.M., Breininger J.F., Baskin D.G., Schwartz M.W. Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1:1998;271-272.
38. Mizuno T.M., Mobbs C.V. Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting. Endocrinology. 140:1999;814-817.
39. Ziotopoulou M., Mantzoros C.S., Hileman S.M., Flier J.S. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am. J. Physiol. 279:2000;E838-E845.
40. faf) rats. Endocrinology. 141:2000;2465-2471.
41. Korner J., Savontaus E., Chua S.C., Leibel R.L., Wardlaw S.L. Leptin regulation of Agrp and NPY mRNA in the rat hypothalmus. J. Neuroendocrinol. 13:2001;959-966.
42. Cai X., Widdowson P.S., Harrold J., Wilson S., Buckingham R., Arch J.R.S.et al. Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes. 48:1999;2132-2137.
43. Cai X.J., Denis R., Vernon R.G., Clapham J.C., Wilson S., Arch J.R.S.et al. Food restriction selectively increases hypothalamic orexin-B levels in lactating rats. Regul. Pept. 97:2001;163-168.
44. Lu C.C., Tsai S.C., Wang S.W., Tsai C.L., Lau C.P., Shih H.C.et al. Effects of ovarian steroid hormones and thyroxine on calcitonin secretion in pregnant rats. Am. J. Physiol. 274:1998;E246-E252.
45. McCormack J.T., Greenwald G.S. Progesterone and oestradiol-17β concentrations in the peripheral plasma during pregnancy in the mouse. J. Endocrinol. 62:1974;101-107.
46. Grueso E., Rocha M., Puerta M. Plasma and cerebrospinal fluid leptin levels are maintained despite enhanced food intake in progesterone-treated rats. Eur. J. Endocrinol. 144:2001;659-665.
47. Thomas A., Shughrue P.J., Merchenthaler I., Amico J.A. The effects of progesterone on oxitocin mRNA levels in the paraventricular nucleus of the female rat can be altered by administration of diazepan or RU486. J. Neuroendocrinol. 11:1999;137-144.
48. Francis K., Meddle S.L., Bishop V.R., Russell J.A. Progesterone receptor expression in the pregnant and parturient rat hypothalamus and brainstem. Brain Res. 927:2002;18-26.