The allelic variant of LAR gene promoter -127 bp T→A is associated with reduced risk of obesity and other features related to insulin resistance

Journal of Molecular Medicine

Volumn 82, Issue 7, 2004, Pages 459-466

  Miscio, Giuseppe ^a,e   Tassi, Vittorio ^a,f,g   Coco, Angelo ^a   Soccio, Teresa ^a   Di Paola, Rosa ^a   Prudente, Sabrina ^a,c   Baratta, Roberto ^b   Frittitta, Lucia ^b   Ludovico, Ornella ^a   Padovano, Libera ^a   Dallapiccola, Bruno ^c,d   Di Mario, Umberto ^d   De Cosmo, Salvatore ^a   Trischitta, Vincenzo ^a,c,d  

^a CSS Scientific Institute   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF CAMERINO   (Italy)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^g UNIVERSITY OF MILAN   (Italy)

Author keywords

Insulin resistance; Leukocyte antigen related; Protein tyrosine phosphatases

Indexed keywords

ALBUMIN; COMPLEMENTARY DNA; CREATININE; DNA; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CAUCASIAN; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DNA SEQUENCE; DNA TRANSFECTION; EXPERIMENT; FEMALE; GENE; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; ITALY; LAR GENE; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; POPULATION RESEARCH; PROMOTER REGION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RISK REDUCTION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM; TRANSCRIPTION INITIATION SITE; TRIACYLGLYCEROL BLOOD LEVEL; URINE LEVEL;

EID: 3843097204     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-004-0544-1     Document Type: Article

References (24)

1. Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595-1607
2. Kahn BB, Flier J (2000) Obesity and insulin resistance. J Clin Invest 106:473-481
3. Stern MP (2000) Strategies and prospects for finding insulin resistance genes. J Clin Invest 106:323-327
4. Almind K, Doria A, Kahn CR (2001) Putting the genes for type 2 diabetes on the map. Nat Med 7:277-279
5. Virkamaki A, Ueki K, Kahn CR (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943
6. Goldstein BJ, Ahmad F, Ding W, Li P, Zhang W (1998) Regulation of the insulin signaling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 182:91-99
7. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chang CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283:1544-1548
8. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB (2000) Increased energy expenditure decreased adiposity and tissue-specific insulin sensitivity in protein tyrosine phosphatase 1B-deficient mice. Mol Cell Biol 20:5479-5489
9. Tsujikawa K, Kawakami N, Uchino Y, Ichijo T, Furukawa T, Saito H, Yamamoto H (2001) Distint functions of the two protein tyrosine phosphatase domains of LAR (leucocyte common antigen-related) on tyrosine dephosphorylation of the insulin receptor. Mol Endocrinol 15:271-280
10. Ahmad F, Goldstein BJ (1997) Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells. J Biol Chem 272:448-457
11. Zabolotny JM, Kim Y, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG (2001) Overexpression of the LAR (leucocyte antigen-related) protein-tyrosine phosphatase in muscle cause insulin resistance. Proc Natl Acad Sci USA 98:5187-5192
12. Ren J, Li P, Zhang W, Sweet LJ, Cline G, Shulman GI, Livingston JN, Goldstein BJ (1998) Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis. Diabetes 47:493-497
13. Ahmad F, Considine RV, Goldstein BJ (1995) Increased abundance of the receptor-type protein-tyrosine phosphatase LAR accounts for the elevated insulin receptor dephosphorylating activity in adipose tissue of obese human subjects. J Clin Invest 95:2806-2812
14. Ahmad F, Azevedo JL, Cortright R, Dohm GL, Goldstein BJ (1997) Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J Clin Invest 100:449-458
15. Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta, Centra M, Spampinato D, Santagati MG, Ercolino T, Cisternino C, Soccio T, Mastroianno S, Tassi V, Almgren P, Pizzuti A, Vigneri R, Trischitta V (2002) A variation in the 3′ UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am J Hum Genet 70:806-812
16. Frittitta L, Ercolino T, Bozzali M, Argiolas A, Graci S, Santagati MG, Spampinato D, Di Paola R, Cisternino C, Tassi V, Vigneri R, Pizzuti A, Trischitta V (2001) A cluster of three single nucleotide polymorphism in the 3′-untraslated region of human glycoprotein PC-1 gene stabilises PC-1 protein content and insulin resistance-related abnormalities. Diabetes 50:1952-1955
17. Chen C, Okayama H (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
18. Schneider S, Roessli D, Excoffier L (2000) Arlequin v 2.000: A software for population genetics data analysis. Genetics and Biometry Laboratory, University of Geneva, Switzerland
19. Echwald SM, Bach H, Vestergaard H, Richelsen B, Kristensen K, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (2002) A P387L variant in protein tyrosine phosphatase-1B (PTP-1B) is associated with type 2 diabetes and impaired serine phosphorylation of PTP-1B in vitro. Diabetes 51:1-6
20. Mok A, Cao H, Zinman B, Hanley AJG, Harris BS, Kennedy BP, Hegele R (2002) A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree. J Clin Endocrinol Metab 87:724-727
21. Mattock MB, Morrish NJ, Viberti G, Keen H, Fitzgerald AP, Jackson G (1992) Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 41:736-741
22. Wu X, Hoffstedt J, Deeb W, Singh R, Sedkova N, Zilbering A, Zhu L, Park PK, Arner P, Goldstein BJ (2001) Depot-specific variation in protein-tyrosine phosphatase activities in human omental and subcutaneous adipose tissue: a potential contribution to differential insulin sensitivity. J Clin Endocrinol Metab 86:5973-5980
23. Kennedy BP, Ramachandran C (2000) Protein tyrosine phosphatase-1B in diabetes. Biochem Pharmacol 60:877-833
24. Zinker BA, Rondinone CM, Trevillyan JM, Gum RJ, Clampit JE, Waring JF, Xie N, Wilcox D, Jacobson P, Frost L, Kroeger PE, Reilly RM, Koterski S, Opgenorth TJ, Ulrich RG, Crosby S, Butler M, Murray SF, McKay RA, Bhanot S, Monia BP, Jirousek MR (2002) PTP1B antisense oligonucleotide lowers PTP1B protein, normalises blood glucose, and improves insulin sensitivity in diabetic mice. Proc Natl Acad Sci USA 99:11357-11362