A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in oji-cree

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 2, 2002, Pages 724-727

  Mok, Andrea ^a   Cao, Henian ^b   Zinman, Bernard ^c   Hanley, Anthony J G ^a   Harris, Stewart B ^d   Kennedy, Brian P ^a   Hegele, Robert A ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; RESTRICTION ENDONUCLEASE; THIAMINE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANADA; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENE SEQUENCE; GENETIC RISK; GENOTYPE; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HETEROZYGOTE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0036173341     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.87.2.8253     Document Type: Article

References (27)

1. Role of protein tyrosine phosphatase-1B in diabetes and obesity
2. Protein tyrosine phosphatase-1B in diabetes
3. Purification of the major protein-tyrosine-phosphatases of human placenta
4. Human placenta protein-tyrosine-phosphatase: Amino acid sequence and relationship to a family of receptor-like proteins
5. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
6. New susceptibility locus for NIDDM is localized to human chromosome 20q
7. Exclusion of the hepatocyte nuclear factor 4 as a candidate gene for late-onset NIDDM linked with chromosome 20q
8. A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
9. Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2
10. Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B
11. Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes
12. The prevalence of NIDDM and associated risk factors in native Canadians
13. Genome-wide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers
14. The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree
15. Variation in the AU(AT)-rich element within the 3′-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians
16. Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians
17. Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus
18. Methylenetetrahydrofolate reductase gene, dietary folate, NIDDM, and atherosclerosis in Canadian Oji-Cree
19. Hemochromatosis and diabetes mellitus
20. Peroxisome proliferator-activated receptor-γ2 P12A and type 2 diabetes in Canadian Oji-Cree
21. Specific patterns of food consumption and preparation are associated with diabetes and obesity in a native Canadian community
22. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance
23. Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B
24. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy
25. A point mutation in PTPRC is associated with the development of multiple sclerosis
26. Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease