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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 16, 2002, Pages 2149-2152

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: Prevention of reactive intermediate formation and covalent binding

(9) Chauret, Nathalie a Guay, Daniel a Li, Chun a Day, Stephen a Silva, José a Blouin, Marc a Ducharme, Yves a Yergey, James A a Nicoll Griffith, Deborah A a

a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; CATECHOL DERIVATIVE; DRUG METABOLITE; L 791 943; L 971 943; PHOSPHODIESTERASE IV INHIBITOR; PROTEIN; ROLIPRAM; UNCLASSIFIED DRUG; 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CATECHOL; PHOSPHODIESTERASE IV; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; LIVER MICROSOME; METABOLISM; PROTEIN BINDING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; CATECHOLS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PROTEIN BINDING; PYRIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037136003 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00349-9 Document Type: Article

Times cited : (60)

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