Differential roles of integrins α2β1 and αIIbβ3 collagen and CRP-induced platelet activation

Platelets

Volumn 15, Issue 5, 2004, Pages 303-313

  Jarvis, Gavin E ^a,b   Best, Denise ^a   Watson, Steve P ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; ALPHA2BBETA3 INTEGRIN; C REACTIVE PROTEIN; COLLAGEN; COLLAGEN FIBER; INDOMETACIN; LOTRAFIBAN; PADGEM PROTEIN; THROMBOXANE A2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LINEAR REGRESSION ANALYSIS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADENOSINE DIPHOSPHATE; BENZODIAZEPINES; CARRIER PROTEINS; COLLAGEN; CYTOPLASMIC GRANULES; HUMANS; INTEGRIN ALPHA2BETA1; P-SELECTIN; PEPTIDES; PIPERIDINES; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE-PHOSPHATASE; THROMBOXANE A2;

EID: 3843058056     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/09537100410001710254     Document Type: Article

References (60)

1. Moroi M, Jung S M, Okuma M, Shinmyozu K. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest 1989; 84: 1440-5.
2. Clemetson J M, Polgar J, Magnenat E, Wells T N, Clemetson K J. The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors. J Biol Chem 1999; 274: 29019-24.
3. Santoro S A, Rajpara S M, Staatz W D, Woods V L, Jr. Isolation and characterization of a platelet surface collagen binding complex related to VLA-2. Biochem Biophys Res Commun 1988; 153: 217-23.
4. Nieuwenhuis H K, Akkerman J W, Houdijk W P, Sixma J J. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nature 1985; 318: 470-2.
5. Clemetson K J, Clemetson J M. Platelet collagen receptors. Thromb Haemost 2001; 86: 189-97.
6. Barnes M J, Knight C G, Farndale R W. The collagen-platelet interaction. Curr Opin Hematol 1998; 5: 314-20.
7. Watson S, Berlanga O, Best D, Frampton J. Update on collagen receptor interactions in platelets: is the two-state model still valid? Platelets 2000; 11: 252-8.
8. Jarvis G E, Atkinson B T, Snell D C, Watson S P. Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens. Br J Pharmacol 2002; 137: 107-17.
9. Poole A, Gibbins J M, Turner M, van Vugt M J, van de Winkel J G, Saito T, et al. The Fc receptor gamma-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 1997; 16: 2333-41.
10. Ichinohe T, Takayama H, Ezumi Y, Arai M, Yamamoto N, Takahashi H, et al. Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI. J Biol Chem 1997; 272: 63-8.
11. Nieswandt B, Bergmeier W, Schulte V, Rackebrandt K, Gessner J E, Zirngibl H. Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain. J Biol Chem 2000; 275: 23998-4002.
12. Kehrel B, Wierwille S, Clemetson K J, Anders O, Steiner M, Knight C G, et al. Glycoprotein VI is a major collagen receptor for platelet activation: it recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood 1998; 91: 491-9.
13. Knight C G, Morton L F, Onley D J, Peachey A R, Ichinohe T, Okuma M, et al. Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen. Cardiovasc Res 1999; 41: 450-7.
14. Morton L F, Hargreaves P G, Farndale R W, Young R D, Barnes M J. Integrin alpha 2 beta 1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for alpha 2 beta 1-independent platelet reactivity. Biochem J 1995; 306: 337-44.
15. Knight C G, Morton L F, Onley D J, Peachey A R, Messent A J, Smethurst P A, et al. Identification in collagen type I of an integrin alpha2 beta1-binding site containing an essential GER sequence. J Biol Chem 1998; 273: 33287-94.
16. Knight C G, Morton L F, Peachey A R, Tuckwell D S, Farndale R W, Barnes M J. The collagen-binding A-domains of integrins alpha()beta(1) and alpha(2)beta(1) recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens. J Biol Chem 2000; 275: 35-40.
17. Emsley J, Knight C G, Farndale R W, Barnes M J, Liddington R C. Structural basis of collagen recognition by integrin alpha2beta1. Cell 2000; 101: 47-56.
18. Moog S, Mangin P, Lenain N, Strassel C, Ravanat C, Schuhler S, et al. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Blood 2001; 98: 1038-46.
19. Tandon N N, Kralisz U, Jamieson G A. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem 1989; 264: 7576-83.
20. Monnet E, Fauvel-Lafeve F. A new platelet receptor specific to type III collagen. Type III collagen-binding protein. J Biol Chem 2000; 275: 10912-7.
21. Chiang T M, Cole F, Woo-Rasberry V. Cloning, characterization, and functional studies of a 47-kDa platelet receptor for type III collagen. J Biol Chem 2002; 277: 34896-901.
22. Chiang T M, Rinaldy A, Kang A H. Cloning, characterization, and functional studies of a nonintegrin platelet receptor for type I collagen. J Clin Invest 1997; 100: 514-21.
23. Coller B S, Beer J H, Scudder L E, Steinberg M H. Collagen-platelet interactions: evidence for a direct interaction of collagen with platelet GPIa/IIa and an indirect interaction with platelet GPIIb/IIIa mediated by adhesive proteins. Blood 1989; 74: 182-92.
24. Nieswandt B, Brakebusch C, Bergmeier W, Schulte V, Bouvard D, Mokhtari-Nejad R, et al. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J 2001; 20: 2120-30.
25. Atkinson B, Jarvis G E, Watson S P. Activation of GPVI by collagen is regulated by alpha(2)beta(1) and secondary mediators. J Thromb Haemost 2003; 1: 1278-87.
26. Nakamura T, Kambayashi J, Okuma M, Tandon N N. Activation of the GP IIb-IIIa complex induced by platelet adhesion to collagen is mediated by both alpha2beta1 integrin and GP VI. J Biol Chem 1999; 274: 11897-903.
27. Mangin P, Nonne C, Eckly A, Ohlmann P, Freund M, Nieswandt B, et al. A PLCgamma2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha(2)beta(1). FEBS Lett 2003; 542: 53-9.
28. Inoue O, Suzuki-Inoue K, Dean W L, Frampton J, Watson S P. Integrin {alpha}2{beta}1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLC{gamma}2. J Cell Biol 2003; 160: 769-80.
29. Heptinstall S, Bevan J, Cockbill S R, Hanley S P, Parry M J. Effects of a selective inhibitor of thromboxane synthetase on human blood platelet behaviour. Thromb Res 1980; 20: 219-30.
30. Zucker M B, Peterson J. Inhibition of adenosine diphosphate-induced secondary aggregation and other platelet functions by acetylsalicylic acid ingestion. Proc Soc Exp Biol Med 1968; 127: 547-51.
31. Pollock W K, Rink T J, Irvine R F. Liberation of [3H]arachidonic acid and changes in cytosolic free calcium in fura-2-loaded human platelets stimulated by ionomycin and collagen. Biochem J 1986; 235: 869-77.
32. Zucker M B, Peterson J. Effect of acetylsalicylic acid, other nonsteroidal anti-inflammatory agents, and dipyridamole on human blood platelets. J Lab Clin Med 1970; 76: 66-75.
33. O'Brien J R. Effects of salicylates on human platelets. Lancet 1968; 1: 779-83.
34. Rosenberg J C, Sell T L. In vitro evaluation of inhibitors of platelet release and aggregation. Arch Surg 1975; 110: 980-3.
35. Sils D, Rodgers S E, Lloyd J V, Wilson K M, Siebert D M, Bochner F. Inhibition of platelet aggregation and thromboxane production by low concentrations of aspirin in vitro. Clin Sci (London) 1988; 74: 491-7.
36. Weiss H J, Aledort L M. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet 1967; ii: 495-7.
37. Evans G, Packham M A, Nishizawa E E, Mustard J F, Murphy E A. The effect of acetylsalicyclic acid on platelet function. J Exp Med 1968; 128: 877-94.
38. Hovig T. Release of a platelet-aggregating substance (adenosine diphosphate) from rabbit blood platelets induced by saline 'extract' of tendons. Thromb Diath Haemorrh 1963; 9: 264-78.
39. Ardlie N G, Garrett J J, Bell L K. Collagen increases cytoplasmic free calcium in human platelets. Thromb Res 1986; 42: 115-24.
40. Cho M J, Liu J, Pestina T I, Steward S A, Thomas D W, Coffman T M, et al. The roles of {alpha}IIb{beta}3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood 2003; 101: 2646-51.
41. Atkinson B T, Stafford M J, Pears C J, Watson S P. Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin. Eur J Biochem 2001; 268: 5242-8.
42. Quinton T M, Ozdener F, Dangelmaier C, Daniel J L, Kunapuli S P. Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP. Blood 2002; 99: 3228-34.
43. Offermanns S, Toombs C F, Hu Y H, Simon M I. Defective platelet activation in G alpha(q)-deficient mice. Nature 1997; 389: 183-6.
44. Fabre J E, Nguyen M, Latour A, Keifer J A, Audoly L P, Coffman T M, et al. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Nat Med 1999; 5: 1199-202.
45. Leon C, Hechler B, Freund M, Eckly A, Vial C, Ohlmann P, et al. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. J Clin Invest 1999; 104: 1731-7.
46. Born G V R, Cross M J. The aggregation of blood platelets. J Physiol 1963; 168: 178-95.
47. Jarvis G E, Humphries R G, Robertson M J, Leff P. ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors. Br J Pharmacol 2000; 129: 275-82.
48. Bevan J, Heptinstall S. Serotonin-induced platelet aggregation in whole blood and the effects of ketanserin and mepyramine. Thromb Res 1985; 38: 189-94.
49. Frojmovic M M, Milton J G, Duchastel A. Microscopic measurements of platelet aggregation reveal a low ADP-dependent process distinct from turbidometrically measured aggregation. J Lab Clin Med 1983; 101: 964-76.
50. Jarvis G E, Evans R J, Heath M F. The role of ADP in endotoxin-induced equine platelet activation. Eur J Pharmacol 1996; 315: 203-12.
51. Lundin A, Hasenson M, Persson J, Pousette A. Estimation of biomass in growing cell lines by adenosine triphosphate assay. Methods Enzymol 1986; 133: 27-42.
52. Jarvis G E, Atkinson B T, Frampton J, Watson S P. Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb. Br J Pharmacol 2003; 138: 574-83.
53. De Lean A, Munson P J, Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radio-ligand assay, and physiological dose-response curves. Am J Physiol 1978; 235: E97-102.
54. Snell D C, Schulte V, Jarvis G E, Arase K, Sakurai D, Saito T, et al. Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands. Biochem J 2002; 368: 293-300.
55. Nieswandt B, Schulte V, Zywietz A, Gratacap M P, Offermanns S. Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets. J Biol Chem 2002; 277: 39493-8.
56. Jung S M, Moroi M. Platelets interact with soluble and insoluble collagens through characteristically different reactions. J Biol Chem 1998; 273: 14827-37.
57. Rosado J A, Meijer E M, Hamulyak K, Novakova I, Heemskerk J W, Sage S O. Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets. Blood 2001; 97: 2648-56.
58. Padoin E, Alexandre A, Cavallini L, Polverino de Laureto P, Rao G H, Doni M G. Human platelet activation is inhibited by the occupancy of glycoprotein IIb/IIIa receptor. Arch Biochem Biophys 1996; 333: 407-13.
59. Li Z, Zhang G, Le Breton G C, Gao X, Malik A B, Du X. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem 2003; 278: 30725-31.
60. Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave J P, et al. Evidence for crosstalk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. Blood 2001; 97: 3829-35.