Osteoclast size heterogeneity in rat long bones is associated with differences in adhesive ligand specificity

Experimental Cell Research

Volumn 314, Issue 3, 2008, Pages 638-650

  Hu, Yingwei ^a   Ek Rylander, Barbro ^a   Karlström, Erik ^a   Wendel, Mikael ^a   Andersson, Göran ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bone resorption; Cathepsin K; Cell adhesion; Fibronectin; Integrins; Osteoclasts; Osteopontin; Prothrombin; Thrombin

Indexed keywords

BETA1 INTEGRIN; BETA3 INTEGRIN; CATHEPSIN K; FIBRONECTIN; GELATINASE B; MESSENGER RNA; OSTEOPONTIN; PROTHROMBIN; THROMBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MATRIX; CELL ADHESION; CYTOPLASM; LONG BONE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT;

BOVINAE; RATTUS;

EID: 38349077157     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.11.008     Document Type: Article

References (61)

1. Goldsack N.R., Chambers R.C., Dabbagh K., and Laurent G.J. Thrombin. Int. J. Biochem. Cell Biol. 30 (1998) 641-646
2. Jarvis G.E., Atkinson B.T., Frampton J., and Watson S.P. Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb. Br. J. Pharmacol. 138 (2003) 574-583
3. Pajdak W., Radwan J., and Guzik T.J. Cleavage of prothrombin bound in immune complexes results in high thrombin enzymatic activity. J. Physiol. Pharmacol. 55 (2004) 477-484
4. Torbet J. The thrombin activation pathway modulates the assembly, structure and lysis of human plasma clots in vitro. Thromb. Haemost. 73 (1995) 785-792
5. Ayala Y.M., Cantwell A.M., Rose T., Bush L.A., Arosio D., and Di Cera E. Molecular mapping of thrombin-receptor interactions. Proteins 45, (2001) 107-116
6. Vliagoftis H. Thrombin induces mast cell adhesion to fibronectin: evidence for involvement of protease-activated receptor-1. J. Immunol. 169 (2002) 4551-4558
7. Abraham L.A., Jenkins A.L., Stone S.R., and Mackie E.J. Expression of the thrombin receptor in developing bone and associated tissues. J. Bone Miner. Res. 13 (1998) 818-827
8. Abraham L.A., and MacKie E.J. Modulation of osteoblast-like cell behavior by activation of protease-activated receptor-1. J. Bone Miner. Res. 14 (1999) 1320-1329
9. Gustafson G.T., and Lerner U. Thrombin, a stimulator of bone resorption. Biosci. Rep. 3 (1983) 255-261
10. Hoffmann O., Klaushofer K., Koller K., Peterlik M., Mavreas T., and Stern P. Indomethacin inhibits thrombin-, but not thyroxin-stimulated resorption of fetal rat limb bones. Prostaglandins 31 (1986) 601-608
11. Lerner U.H., and Gustafson G.T. Blood coagulation and bone metabolism: some characteristics of the bone resorptive effect of thrombin in mouse calvarial bones in vitro. Biochim. Biophys. Acta. 964 (1988) 309-318
12. Feyen J.H., van der Wilt G., Moonen P., Di Bon A., and Nijweide P.J. Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs. Prostaglandins 28 (1984) 769-781
13. Ljunggren O., Johansson H., Ljunghall S., and Lerner U.H. Thrombin increases cytoplasmic Ca2+ and stimulates formation of prostaglandin E2 in the osteoblastic cell line MC3T3-El. Bone Miner. 12 (1991) 81-90
14. Kozawa O., Tokuda H., Kaida T., Matsuno H., and Uematsu T. Thrombin regulates interleukin-6 synthesis through phosphatidylcholine hydrolysis by phospholipase D in osteoblasts. Arch. Biochem. Biophys. 345 (1997) 10-15
15. Suzuki A., Kozawa O., Shinoda J., Watanabe-Tomita Y., Saito H., and Oiso Y. Mechanism of thrombin-induced arachidonic acid release in osteoblast-like cells. Prostaglandins Leukot. Essent. Fatty Acids 56 (1997) 467-472
16. Abraham L.A., Chinni C., Jenkins A.L., Lourbakos A., Ally N., Pike R.N., and Mackie E.J. Expression of protease-activated receptor-2 by osteoblasts. Bone 26 (2000) 7-14
17. Smith R., Ransjo M., Tatarczuch L., Song S.J., Pagel C., Morrison J.R., Pike R.N., and Mackie E.J. Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation. J. Bone Miner. Res. 19 (2004) 507-516
18. Pagel C.N., de Niese M.R., Abraham L.A., Chinni C., Song S.J., Pike R.N., and Mackie E.J. Inhibition of osteoblast apoptosis by thrombin. Bone 33 (2003) 733-743
19. Vaananen H.K., and Harkonen P.L. Estrogen and bone metabolism. Maturitas 23 (1996) S65-S69 Suppl
20. Blair H.C., Robinson L.J., and Zaidi M. Osteoclast signalling pathways. Biochem. Biophys. Res. Commun. 328 (2005) 728-738
21. Ross F.P., and Teitelbaum S.L. Alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol. Rev. 208 (2005) 88-105
22. Teitelbaum S.L. Osteoclasts and integrins. Ann. N. Y. Acad. Sci. 1068 (2006) 95-99
23. Samanna V., Ma T., Mak T.W., Rogers M., and Chellaiah M.A. Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function. J. Cell. Physiol. 213 (2007) 710-720
24. Hayer S., Steiner G., Gortz B., Reiter E., Tohidast-Akrad M., Amling M., Hoffmann O., Redlich K., Zwerina J., Skriner K., Hilberg F., Wagner E.F., Smolen J.S., and Schett G. CD44 is a determinant of inflammatory bone loss. J. Exp. Med. 201 (2005) 903-914
25. McHugh K.P., Hodivala-Dilke K., Zheng M.H., Namba N., Lam J., Novack D., Feng X., Ross F.P., Hynes R.O., and Teitelbaum S.L. Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest. 105 (2000) 433-440
26. Davie E.W., and Kulman J.D. An overview of the structure and function of thrombin. Semin. Thromb. Hemost. 32 Suppl 1 (2006) 3-15
27. Stouffer G.A., and Smyth S.S. Effects of thrombin on interactions between beta3-integrins and extracellular matrix in platelets and vascular cells. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1971-1978
28. Lecrone V., Li W., Devoll R.E., Logothetis C., and Farach-Carson M.C. Calcium signals in prostate cancer cells: specific activation by bone-matrix proteins. Cell Calcium 27 (2000) 35-42
29. Senger D.R., Perruzzi C.A., Papadopoulos-Sergiou A., and Van de Water L. Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain. Mol. Biol. Cell 5 (1994) 565-574
30. Senger D.R., and Perruzzi C.A. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim. Biophys. Acta. 1314 (1996) 13-24
31. Smith L.L., Cheung H.K., Ling L.E., Chen J., Sheppard D., Pytela R., and Giachelli C.M. Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin. J. Biol. Chem. 271 (1996) 28485-28491
32. Byzova T.V., and Plow E.F. Networking in the hemostatic system. Integrin alphaiibbeta3 binds prothrombin and influences its activation. J. Biol. Chem. 272 (1997) 27183-27188
33. Byzova T.V., and Plow E.F. Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin. J. Cell Biol. 143 (1998) 2081-2092
34. Bar-Shavit R., Sabbah V., Lampugnani M.G., Marchisio P.C., Fenton II J.W., Vlodavsky I., and Dejana E. An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion. J. Cell Biol. 112 (1991) 335-344
35. Chiang H.S., Yang R.S., and Huang T.F. Thrombin enhances the adhesion and migration of human colon adenocarcinoma cells via increased beta 3-integrin expression on the tumour cell surface and their inhibition by the snake venom peptide, rhodostomin. Br. J. Cancer 73 (1996) 902-908
36. Bayless K.J., Davis G.E., and Meininger G.A. Isolation and biological properties of osteopontin from bovine milk. Protein Expr. Purif. 9 (1997) 309-314
37. Ljusberg J., Ek-Rylander B., and Andersson G. Tartrate-resistant purple acid phosphatase is synthesized as a latent proenzyme and activated by cysteine proteinases. Biochem. J. 343 Pt 1 (1999) 63-69
38. Hu Y., Nyman J., Muhonen P., Vaananen H.K., and Laitala-Leinonen T. Inhibition of the osteoclast V-ATPase by small interfering RNAs. FEBS Lett. 579 (2005) 4937-4942
39. In: Noorden J.M.P.A.S.V. (Ed). Immunocytochemistry: Modern Methods and Applications (1986), Wright, Bristol
40. Song S.J., Pagel C.N., Campbell T.M., Pike R.N., and Mackie E.J. The role of protease-activated receptor-1 in bone healing. Am. J. Pathol. 166 (2005) 857-868
41. Pagel C.N., Sivagurunathan S., Loh L.H., Tudor E.M., Pike R.N., and Mackie E.J. Functional responses of bone cells to thrombin. Biol. Chem. 387 (2006) 1037-1041
42. Yokosaki Y., Matsuura N., Sasaki T., Murakami I., Schneider H., Higashiyama S., Saitoh Y., Yamakido M., Taooka Y., and Sheppard D. The integrin alpha(9)beta(1) binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin. J. Biol. Chem. 274 (1999) 36328-36334
43. Yokosaki Y., Tanaka K., Higashikawa F., Yamashita K., and Eboshida A. Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin. Matrix Biol. 24 (2005) 418-427
44. Rao H., Lu G., Kajiya H., Garcia-Palacios V., Kurihara N., Anderson J., Patrene K., Sheppard D., Blair H.C., Windle J.J., Choi S.J., and Roodman G.D. Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J. Bone Miner. Res. 21 (2006) 1657-1665
45. Smith L.L., and Giachelli C.M. Structural requirements for alpha 9 beta 1-mediated adhesion and migration to thrombin-cleaved osteopontin. Exp. Cell Res. 242 (1998) 351-360
46. Flores M.E., Heinegard D., Reinholt F.P., and Andersson G. Bone sialoprotein coated on glass and plastic surfaces is recognized by different beta 3 integrins. Exp. Cell Res. 227 (1996) 40-46
47. Katagiri Y.U., Sleeman J., Fujii H., Herrlich P., Hotta H., Tanaka K., Chikuma S., Yagita H., Okumura K., Murakami M., Saiki I., Chambers A.F., and Uede T. CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis. Cancer Res. 59 (1999) 219-226
48. Inoue M., Ross F.P., Erdmann J.M., Abu-Amer Y., Wei S., and Teitelbaum S.L. Tumor necrosis factor alpha regulates alpha(v)beta5 integrin expression by osteoclast precursors in vitro and in vivo. Endocrinology 141 (2000) 284-290
49. Trebec D.P., Chandra D., Gramoun A., Li K., Heersche J.N., and Manolson M.F. Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases. J. Cell Biochem. 101 (2007) 205-220
50. Nakamura I., Pilkington M.F., Lakkakorpi P.T., Lipfert L., Sims S.M., Dixon S.J., Rodan G.A., and Duong L.T. Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone. J. Cell Sci. 112 Pt 22 (1999) 3985-3993
51. Helfrich M.H., Nesbitt S.A., Lakkakorpi P.T., Barnes M.J., Bodary S.C., Shankar G., Mason W.T., Mendrick D.L., Vaananen H.K., and Horton M.A. Beta 1 integrins and osteoclast function: involvement in collagen recognition and bone resorption. Bone 19 (1996) 317-328
52. Piper K., Boyde A., and Jones S.J. The relationship between the number of nuclei of an osteoclast and its resorptive capability in vitro. Anat. Embryol. (Berl) 186 (1992) 291-299
53. Lees R.L., Sabharwal V.K., and Heersche J.N. Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films. Bone 28 (2001) 187-194
54. Manolson M.F., Yu H., Chen W., Yao Y., Li K., Lees R.L., and Heersche J.N. The a3 isoform of the 100-kDa V-ATPase subunit is highly but differentially expressed in large (>or= 10 nuclei) and small (
55. Aota S., Nakamura T., Suzuki K., Tanaka Y., Okazaki Y., Segawa Y., Miura M., and Kikuchi S. Effects of indomethacin administration on bone turnover and bone mass in adjuvant-induced arthritis in rats. Calcif. Tissue Int. 59 (1996) 385-391
56. Kaye M., Zucker S.W., Leclerc Y.G., Prichard S., Hodsman A.B., and Barre P.E. Osteoclast enlargement in endstage renal disease. Kidney Int. 27 (1985) 574-581
57. Makris G.P., and Saffar J.L. Quantitative relationship between osteoclasts, osteoclast nuclei and the extent of the resorbing surface in hamster periodontal disease. Arch. Oral Biol. 27 (1982) 965-969
58. Roodman G.D. Paget's disease and osteoclast biology. Bone 19 (1996) 209-212
59. Shu G., Yamamoto K., and Nagashima M. Differences in osteoclast formation between proximal and distal tibial osteoporosis in rats with adjuvant arthritis: inhibitory effects of bisphosphonates on osteoclasts. Mod. Rheumatol. 16 (2006) 343-349
60. Lees R.L., and Heersche J.N. Macrophage colony stimulating factor increases bone resorption in dispersed osteoclast cultures by increasing osteoclast size. J. Bone Miner. Res. 14 (1999) 937-945
61. Flores M.E., Norgard M., Heinegard D., Reinholt F.P., and Andersson G. RGD-directed attachment of isolated rat osteoclasts to osteopontin, bone sialoprotein, and fibronectin. Exp. Cell Res. 201 (1992) 526-530