Thrombin enhances the adhesion and migration of human colon adenocarcinoma cells via increased β3-integrin expression on the tumour cell surface and their inhibition by the snake venom peptide, rhodostomin

British Journal of Cancer

Volumn 73, Issue 7, 1996, Pages 902-908

  Chiang, H S ^a   Yang, R S ^a   Huang, T F ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Arg Gly Asp containing peptide; Metastasis; Protein kinase C; Thrombin; 3 integrin

Indexed keywords

3,4 DICHLOROISOCOUMARIN; ANTITHROMBOCYTIC AGENT; CYCLOHEXIMIDE; DACTINOMYCIN; FIBRONECTIN; INTEGRIN; SERINE PROTEINASE; SNAKE VENOM; THROMBIN;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL SURFACE; COLON ADENOCARCINOMA; CONTROLLED STUDY; ENDOTHELIUM; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; METASTASIS; MICROVASCULATURE; PRIORITY JOURNAL; PROTEINASE INHIBITION;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CELL ADHESION; CELL MOVEMENT; COLONIC NEOPLASMS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FIBRONECTINS; HUMANS; INTEGRIN BETA3; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN KINASE C; THROMBIN; TUMOR CELLS, CULTURED;

EID: 0029877330     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.161     Document Type: Article

References (45)

1. BROWN PJ. (1988). Phorbol ester stimulation of fibronectin-mediated cell adhesion. Biochem. Biophys. Res. Commun., 155, 603-607.
2. BRUHN HD AND ZURBORN KH. (1993). Influences of clotting factors (thrombin, factor XIII) and fibronectin on the growth of tumor cells and leukemic cells in vitro. Blut, 46, 85-88.
3. CAVANAUGH PG, SLOANE BF AND HONN KV. (1988). Role of the coagulation system in tumor cell-induced platelet aggregation and metastasis. Haemostasis, 18, 37-46.
4. CHIANG HS, SWAIM MW AND HUANG TF. (1994a). Characterization of platelet aggregation induced by human colon adenocarcinoma cells and its inhibition by snake venom peptides, trigramin and rhodostomin. Br. J. Haematol., 87, 325-331.
5. CHIANG HS, PENG HC AND HUANG TF. (1994b). Characterization of integrin expression and regulation on SW-480 human colon adenocarcinoma cells and the effect of rhodostomin on basal and upregulated tumor cell adhesion. Biochim. Biophys. Acta., 1224, 506-516.
6. CHOPRA H, HATFIELD JS, CHANG YS, GROSSI IM, FITZGERALD LA, O-GARA CY, MARNETT LJ, DIGLIO GA, TAYLOR JD AND HONN KV. (1988). Role of tumor cell cyloskeleton and membrane glycoprotein IRGpIIb/IIIa in platelet adhesion to tumor cell membrane and tumor cell induced platelet aggregation. Cancer Res., 48, 3787-3800.
7. 3 on melanoma cells. Int. J. Cancer, 49, 774-786.
8. COSTANTINI V AND ZACHARSKI LR. (1993). Fibrin and cancer. Thromb. Haemost., 69, 406-414.
9. DI CORLETO PE AND DE LA MOTTE CA. (1989). Thrombin causes increased monocytic-cell adhesion to endothelial cells through a protein kinase C-dependent pathway. Biochem. J., 264, 71-77.
10. 3. J. Biol. Chem., 268, 23087-23092.
11. FENTON JW. (1988). Regulation of thrombin generation and functions. Semin. Thromb. Hemost., 14, 234-240.
12. FITZGERALD LA AND PHILLIPS DR. (1985). Calcium requirement of the platelet membrane glycoprotein IIb/IIIa complex. J. Biol. Chem., 260, 11366-11374.
13. GINSBERG MH, DU X AND PLOW EF. (1992). Inside-out integrin signalling. Curr. Opin. Cell Biol., 4, 766-771.
14. GOMEZ ML, MEDRANO EE, CAFFERATTA EGA AND TELLEZINON MT. (1988). Protein kinase C is differentially regulated by thrombin, insulin, and epidermal growth factor in human mammary tumor cells. Exp. Cell Res., 175, 74-80.
15. GRECO NJ AND JAMIESON GA. (1991). High and moderate affinity pathways for α-thrombin-induced platelet activation. Proc. Soc. Exp. Biol. Med., 198, 792-799.
16. GROSSI IM, HATFIELD JS, FITZGERALD LA, NEWCOMBE M, TAYLOR JD AND HONN KV. (1988). Role of tumor cell glycoproteins immunologically related to glycoproteins Ib and IIb/IIIa in tumor cell-platelet and tumor cell-matrix interactions. FASEB J., 2, 2385-2395.
17. GROSSI IM, FITZGERALD LA, UMBARGER LA, NELSON KK, GIGLIO CA, TAYLOR JD AND HONN KV. (1989). Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res., 49, 1029-1037.
18. HONN KV AND SLOANE BF. (1984). Hemostatic mechanisms and metastasis. Martinus Nijhoff: Boston.
19. HONN KV, TANG DG AND CHEN YQ. (1992a). Adhesion molecules and site-specific metastasis. In Thrombosis: an update. NeriSerneri GG, Gensini GF, Abbate R and Prisco D. (eds.), pp. 269-303. Scientific Press: Florence.
20. 3 integrin expression and function in subpopulations of murine tumors. Exp. Cell Res., 201, 23-32.
21. HUANG TF, HOLT JC, LAKASIEWICZ H AND NIEWIAROWSKI S. (1987a). Trigramin, a low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb IIIa complex. J. Biol. Chem., 262, 16157-16163.
22. HUANG TF, WU YG AND OUYANG C. (1987b). Characterization of a potent platelet aggregation inhibitor from Agkistrodon rhodostoma snake venom. Biochim. Biophys. Acta., 925, 248-257.
23. HUANG TF, HOLT JC, KIRKY EPH AND NIEWIAROWSKI S. (1989). Trigramin: primary structure and its inhibition of von Willebrand Factor binding to glycoprotein IIb-IIIa complex on human platelet. Biochemistry, 28, 661-666.
24. HUANG TK, OUYANG C AND TENG CM. (1990). XIth International Congress on Thrombosis, (Abstract 141). Ljubljana, Yugoslavia.
25. HUANG TF, WANG WJ, TENG CM AND OUYANG C. (1991a). Mechanism of action of the antiplatelet peptide, antin, from Bitis arietans venom. Biochim. Biophys. Acta., 1074, 144-150.
26. HUANG TF, LIU CZ, OUYANG C AND TENG CM. (1991b). Halysin, an Arg-Gly-Asp-containing peptide, inhibits platelet aggregation by acting as fibrinogen receptor antagonist. Biochem. Pharmacol., 42, 1209-1219.
27. JAFFE EA, NACHMAN RL, BECKER CG AND MINNICK CR. (1973). Culture of human endothelial cells derived from umbilical veins. J. Clin. Invest., 52, 2745-2756.
28. LIU B, RENAUD C, NELSON KK, CHEN YQ, BAZAZ R, KOWYNIA J, TIMAR J, DIGLIO CA AND HONN KV. (1992). Protein kinase C-inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization. Int. J. Cancer, 52, 147-152.
29. MCGREGOR BC, MCGREGOR JL, WEISS LM, WOOD GS, CHUNG-HONG HU, BOUKERCHE H AND WARNKE RA. (1989). Presence of cytoadhesins (IIb-IIIa-like glycoproteins) on human metastatic melanomas but not on benign melanocytes. Am. J. Clin. Pathol., 92, 495-499.
30. MANNING DR AND BRASS LF. (1991). The role of GTP-binding proteins in platelet activation. Thromb. Haemost., 66, 393-399.
31. MEDRANO EE, CAFFERATA EGA AND LARCHER F. (1987). Role of thrombin in the proliferative response of T-47D mammary tumor cells. Exp. Cell Res., 172, 354-364.
32. NIERODZIK MLR, KAJUMO F AND KARPATKIN S. (1992). Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo. Cancer Res., 52, 3267-3272.
33. IIb. Science, 254, 845-847.
34. RICKLES FR, LEVINE M AND EDWARDS RL. (1992). Hemostatic alterations in cancer patients. Cancer. Metast. Rev., 11, 237-248.
35. RUCINSKI B, NIEWIAROWSKI S, HOLT JC, SOSEKA T AND KNUDSEN KA. (1990). Batroxostatin, an Arg-Gly-Asp-containing peptide from Bothrops atrox, is a potent inhibitor of platelet aggregation and cell interaction with fibronectin. Biochim. Biophys. Acta., 1054, 257-262.
36. RUOSLAHTI E. (1991). Integrins. J. Clin. Invest., 87, 1-5.
37. SHEBUSKI RJ, RAMJIT DR, BENCEN GH AND POLOKOFF MA. (1989). Characterization and platelet inhibitory activity of Bitistatin, a potent Arginine-Glycine-Aspartic acid-containing peptide from the venom of the viper Bitis arietans. J. Biol. Chem., 264, 21550-21556.
38. VAPORCIYAN AA, JONES ML AND WARD PA. (1993). Rapid analysis of leukocyte-endothelial adhesion. J. Immunol. Method, 159, 93-100.
39. VU T-KH, HUNG DT, WHEATON VI AND COUGHLIN SR. (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell, 64, 1057-1068.
40. 3 expression on the cell surface. Thromb. Res., 68, 233-245.
41. WOJTUKIEWICZ MZ, TANG DG, CIARELLI JJ, NELSON KK, WALZ DA, DIGLIO CA, MAMMEN EF AND HONN KV. (1993). Thrombin increases the metastatic potential of tumor cells. Int. J. Cancer, 54, 793-806.
42. WOJTUKIEWICZ MZ, TANG DG, BEN-JOSEF E, RENAUD C, WALZ DA AND HONN KV. (1995). Solid tumor cells express functional 'tethered ligand' thrombin receptor. Cancer Res., 55, 698-704.
43. ZACHARSKI LR, COSTANTINI V, WOJTUKIEWICZ MZ, MEMOLI VA AND KUDRYK J. (1990). Anticoagulants as cancer therapy. Semin. Oncol., 17, 217-227.
44. ZACHARSKI LR, MEEHAN KR, ALGARRA SM AND CALVO FA. (1992a). Clinical trials with anticoagulant and antiplatelet therapies. Cancer Metast. Rev., 11, 421-431.
45. ZACHARSKI LR, WOJTUKIEWICZ MZ, COSTANTINI V, ORNSTEIN DL AND MEMOLI VA. (1992b). Pathways of coagulation/ fibrinolysis activation in malignancy. Semin. Thromb. Hemost., 18, 104-116.