Acrylamide and human biomonitoring: Statements of the Commission on Human Biomonitoring of the Federal Environmental Agency;Acrylamid und Human-biomonitoring: Stellungnahme der Kommission Human-biomonitoring des Umweltbundesamtes

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz

Volumn 51, Issue 1, 2008, Pages 98-108

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; CARCINOGEN; HEMOGLOBIN;

ANIMAL; ARTICLE; BLOOD; BODY BURDEN; COOKING; DNA ADDUCT; ENVIRONMENTAL MONITORING; FOOD CONTAMINATION; GERMANY; HUMAN; MASS SCREENING; METABOLISM; MUTAGEN TESTING; SMOKING;

ACRYLAMIDE; ANIMALS; BODY BURDEN; CARCINOGENS; COOKERY; DNA ADDUCTS; ENVIRONMENTAL MONITORING; FOOD CONTAMINATION; GERMANY; HEMOGLOBINS; HUMANS; MASS SCREENING; MUTAGENICITY TESTS; SMOKING;

EID: 38349053717     PISSN: 14369990     EISSN: 14371588     Source Type: Journal    
DOI: 10.1007/s00103-008-0424-x     Document Type: Article

References (80)

1. Beratergremium für umweltrelevante Altstoffe der GdCh, 1993. BUA - Stoffbericht 103: Acrylamid. S. Hirzel, Stuttgart
2. US EPA (US Environment Protection Agency) (1993) Acrylamide (CASRN 79-06-1), http://www.epa.gov/iris/subst/0286.htm
3. IARC (1994) Acrylamide. IARC Monogr Eval Carcinog Risks Hum 60:389-434
4. IPCS INCHEM (International Programme on Chemical Safety) (1999) Pesticide Information Monograph on Acrylamide. http://www.inchem.org/documents/pims/ chemical/pim652.htm
5. NTP (National Toxicology Program, U.S. Department of Health and Human Services) (2005) 11th Report on Carcinogens. http://ntp.niehs.nih.gov/
6. DFG (Deutsche Forschungsgemeinschaft) (2006) Acrylamid. In: Henschler D, Greim H (Hrsg) Gesundheitsschädliche Arbeitsstoffe: Toxikologischarbeitsmedizinische Begründungen von MAK-Werten. Wiley-VC, Weinheim
7. European Union Risk Assessment Report (2002) Acrylamide. Office for Official Publications of the European Communities. http://europa.eu.int
8. EU Richtlinie 88/379/EEC (1988) http://eur-lex.europa. eu/LexUriServ/LexUriServ.do?uri = CELEX:31988L0379:EN:HTML
9. Tareke E, Rydberg P, Karlsson P et al. (2002) Acrylamide - a cooking carcinogen? Chem Res Toxicol 13:517-790
10. Mottram DS, Wedzicha BL, Dodson AT (2002) Food chemistry: acrylamide is formed in the maillard reaction. Nature 419:448-449
11. Stadler RH, Blank I, Varga N, et al. (2002) Food chem istry: acrylamide from Maillard reaction products. Nature 419(6906):449-450
12. Zyzak DH, Sanders RA, Stojanovic M, et al. (2003) Acrylamide formation mechanism in heated foods. J Agric Food Chem 51:4782-4787
13. Bundesinstitut für Risikobewertung (2002) Acrylamidgehalte in Lebensmitteln, sortiert nach Warengruppen. Präsentation des Bundesamtes für Verbraucherschutz und Lebensmittelsicherheit vom 4.12.2002. http://www.bfr.bund.de/cd/1857
14. Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit (2006) Untersuchungsergebnisse: Acrylamid in Lebensmitteln. http://www.lgl. bayern.de/lebensmittel/acrylamid/acrylamidwerte.htm
15. Madle S, Broschinski L, Mosbach-Schulz O, et al. (2003) Zur aktuellen Risikobewertung von Acrylamid in Lebensmitteln. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz 46:405-415
16. Mosbach-Schulz O, Seiffert I, Sommerfeld C (2003) Abschätzung der Acrylamid-Aufnahme durch hochbelastete Nahrungsmittel in Deutschland. http://www.bfr.bund.de
17. World Health Organization (2002) Health implications of acrylamide in food. Report of a Joint FAO/WHO consultation, WHO headquarters, Geneva, Switzerland 25-27. June 2002.: http://www.who.int/foodsafety/publications/chem/ en/acrylamide_full.pdf
18. Calleman CJ (1996) The metabolism and pharmacokinetics of acrylamide: implications for mechanisms of toxicity and human risk estimation. Drug Metab Rev 28(4):527-590
19. Schettgen T, Broding HC, Angerer J, Drexler H (2002) Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide - biomarkers in occupational and environmental medicine. Toxicol Letters 134:65-70
20. Kütting B, Schettgen T, Angerer J, Drexler H (2006) Abschlussbericht des Forschungsvorhabens.,Belastung und Beanspruchung der Bevölkerung durch Acrylamid - Quellen und Gesundheitsrisiko".
21. JECFA (2005) Joint FAO/WHO Expert Committee on Food Additives, Sixty-fourth meeting; Rome, 8-17 February http://www.who.int/ipcs/food/jecfa/ summaries/summary_report_64_final.pdf
22. Bader M, Hecker H, Wrbitzky R (2005) Querschnittsstudie zur ernährungs- und tabakrauchbedingten Belastung mit Acrylamid. Dtsch Ärztebl 102(39):A2640-A2643
23. Kütting B, Schettgen T, Beckmann MW, et al. (2005) Influence of diet on exposure to acrylamide - reflections on the validity of a questionnaire. Ann Nutr Metabol 49(3):173-177
24. Smith CJ, Perfetti TA, Rumple MA, et al. (2000).,IARC Group 2A Carcinogens" reported in cigarette mainstream smoke, Food Chem Toxicol 38:371-383
25. European Chemicals Bureau (2002) European Union Risk Assessment Report. http://eccb.jrc.it
26. Rice JM (2005) The carcinogenicity of acrylamide. Mutat Res 580(1-2):3-20
27. McCollister DD, Oyen F, Rowe VK (1964) Toxicology of acrylamide. Toxicol Appl Pharmacol 6(2):172-181
28. Thomann P, Koella WP, Krinke G, et al. (1974) The assessment of peripheral neurotoxicity in dogs: comparative studies with acrylamide and clioquinol. Agents Actions 4(1):47-53
29. Hopkins A (1970) The effect of acrylamide on the peripheral nervous system of the baboon. J Neurol Neurosurg Psychiatry 33(6):805-816
30. Sickles DW, Welter DA, Friedman MA (1995) Acrylamide arrests mitosis and prevents chromosome migration in the absence of changes in spindle microtubules. J Toxicol Environ Health 44(1):73-86
31. Burek JD, Albee RR, Beyer JE, et al. (1980) Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environmental Pathol Toxicol 4(5-6):157-182
32. Johnson KA, Gorzinski SJ, Bodner RA, et al. (1986) Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol 85(2):154-168
33. Friedman MA, Dulak LH, Stedham MA (1995) A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 27:95-105
34. Tyl RW, Friedman MA, Losco PE, et al. (2000) Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water. Reproductive Toxicol 14:385-401
35. Sobel W, Bond GG, Parsons TW, Brenner FE (1986) Acrylamide cohort mortality study. Br J Ind Med 43(11):785-788
36. Collins JJ, Swaen GM, Marsh GM, et al. (1989) Mortality patterns among workers exposed to acrylamide. J Occup Med 31:614-617
37. Marsh GM, Lucas LJ, Youk AO, Schall LC (1999) Mortality patterns among workers exposed to acrylamide: 1994 follow up. Occup Environ Med 56:181-190
38. Mucci LA, Dickman PW, Steineck G, et al. (2003) Dietary acrylamide and cancer of the large bowel, kidney, and bladder: absence of an association in a population-based study in Sweden. Br J Cancer 88(1):84-89
39. Mucci LA, Lindblad P, Steineck G, Adami HO (2004) Dietary acrylamide and risk of renal cell cancer. Int J Cancer 109:774-776
40. Pelucchi C, Franceschi S, Levi F, et al. (2003) Fried potatoes and human cancer. Int J Cancer 105(4):558-560
41. World Health Organization (1985) Acrylamide. Environmental Health Criteria 49. Eigenverlag, Genf
42. Hashimoto K (1980) The toxicity of acrylamide (author's transl). Sangyo Igaku 22(4):233-248
43. Auld RB, Bedwell SF (1967) Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide. Can Med Assoc J 96:652-654
44. Davenport JG, Farrell DF, Sumi M (1976) Giant axonal neuropathy caused by industrial chemicals: neurofilamentous axonal masses in man. Neurology 26(10):919-923
45. Igisu H, Goto I, Kawamura Y, et al. (1975) Acrylamide encephaloneuropathy due to well water pollution. J Neurol Neurosurg Psychiatry 38(6):581-584
46. Hagmar L, Törnqvist M, Nordander C, et al. (2001) Health effects of occupational exposure to acrylamide using haemoglobin adducts as biomarkers of internal dose. Scand J Work Environ Health 27:219-226
47. Calleman CJ, Wu Y, He F, et al. (1994) Relationship between biomarkers of exposure and neurological effects in a group of workers exposed to acrylamide. Toxicol Appl Pharmacol 126(2):361-371
48. Sickles DW, Stone JD, Friedman MA (2002) Fast axonal transport: a site of acrylamide neurotoxicity? Neuro Toxicol 23:223-251
49. LoPachin RM (2002) The role of fast axonal transport in acrylamide pathophysiology: Mechanism or epiphenomenon? Neuro Toxicol 23:253-257
50. Friedman MA (2003) Chemistry, biochemistry, and safety of acrylamide. A review. J Agric Food Chem 51:4504-4526
51. Bergmark E, Calleman CJ, He F, Costa LG (1993) Determination of haemoglobin adducts in humans occupationally exposed to acrylamide. Toxicol Appl Pharmacol 120:45-54
52. Miller MJ, Carter DE, Sipes LG (1982) Pharmacokinetics of acrylamide in fisher 334 rats. Toxicol Appl Pharmacol 63:36-64
53. Fuhr U, Boettcher MI, Kinzig-Schippers M, et al. (2006) Toxicokinetics of acrylamide in humans after ingestion of a defined dose in a test meal to improve risk assessment for acrylamide carcinogenicity. Cancer Epidemiol Biomarkers Prev 15:266-271
54. Boettcher MI, Schettgen T, Kütting B, et al. (2005) Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population. Mutation Res 580:167-176
55. Holtmannspötter H (2006) Acrylamidgehalte in der Frauenmilch und ihre gesundheitliche Bedeutung. Beitrag zur wissenschaftlichen Tagung Muttermilchuntersuchungen im Rahmen des Human-Biomonitorings: Erkenntnisse und künftige Entwicklungen. Würzburg, 27./28. Juni
56. Sörgel F, Weissenbacher R, Kinzig-Schippers M, et al. (2002) Acrylamide: increased concentrations in homemade food and first evidence of its variable absorption from food, variable metabolism and placental and breast milk transfer in humans. Chemotherapy 48:267-274
57. Schettgen T, Kütting B, Hornig M, et al. (2004a) Trans-placental exposure of neonates to acrylamide - a pilot study. Int Arch Occup Environ Health 77:213-216
58. Sumner SC, Fennell TR, Moore TA, et al. (1999) Role of cytochrome P450 2E1 in the metabolism of acrylamide and acrylonitrile in mice. Chem Res Toxicol 12:1110-1116
59. Besaratinia A, Pfeifer GP (2004) Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst 96:1023-1029
60. Sumner SC, MacNeela JP, Fennell TR (1992) Characterization and quantitation of urinary metabolites of [1,2,3-13C]acrylamide in rats and mice using 13C nuclear magnetic resonance spectroscopy. Chem Res Toxicol 5:81-89
61. Paulsson B, Granath F, Grawe J, et al. (2001) The multiplicative model for cancer risk assessment: Applicability to acrylamide. Carcinogenesis 22:817-819
62. Paulsson B, Grawe J, Törnqvist M (2002) Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment. Mutat Res 516(1-2):101-111
63. Fennell TR, Friedman MA (2005) Comparison of acrylamide metabolism in humans and rodents. Adv Exp Med Biol 561:109-116
64. Bergmark E (1997) Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. Chem Res Toxicol 10:78-84
65. Paulsson B, Athanassiadis I, Rydberg P, Törnqvist M (2003) Hemoglobin adducts from glycidamid: acetonization of hydrophilic groups for reproducible gas chromatography/tandem mass spectrometric analysis. Rapid Commun Mass Spectrom 17:1859-1865
66. Schettgen T, Rossbach B, Kütting B, et al. (2004b) Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and nonsmoking persons of the general population. Int J Hyg Environ Health 207:531-539
67. JIFSAN (2004) Acrylamid in food workshop: update - scientific issues, uncertainties and research strategies; toxicology and metabolic consequences working group; April 13-15
68. Segerbeck D, Calleman CJ, Schroeder JL, et al. (1995) Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C] acrylamide. Carcinogenesis 16:1161-1165
69. Da Costa GG, Churchwell MI, Hamilton LP, et al. (2003) DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chem Res Toxicol 16:1328-1337
70. Doerge DR, Young JF, MacDaniel LP, et al. (2005) DNA adducts derived from administration of acrylamide and glycidamide to mice and rats. Mutat Res 580:131-141
71. Kjuus H, Hansteen IL, Ryberg D, et al. (2005) Chromosome aberrations in tunnel workers exposed to acrylamide and N-methylolacrylamide. Scand J Work Environ Health 31(4):300-306
72. Paulsson B, Warholm M, Rannug A, Tornqvist M (2005) In vitro studies of the influence of certain enzymes on the detoxification of acrylamide and glycidamide in blood. Adv Exp Biol 561:127-133
73. Hagmar L, Wirfält W, Paulsson B, Törnqvist M (2005) Differences in hemoglobin adduct levels of acrylamide in the general population with respect to dietary intake, smoking habits and gender. Mutation Res 580:157-165
74. Vesper HW, Ospina M, Meyers T, et al. (2006) Automated method for measuring globin adducts of acrylamide and glycidamide at optimized Edman reaction conditions. Rapid Commun Mass Spectrom 20:959-964
75. HBM-Kommission (1996) Konzept der Referenzund Human-Biomonitoring-Werte (HBM) in der Umweltmedizin. Bundesgesundhbl 39:221-224
76. Bundesinstitut für Risikobewertung (2006) Acrylamidgehalte ausgewählter Lebensmittel. Information Nr. 048/2006 vom 31. Oktober, http://www.bfr.bund.de/cm/208/acrylamidgehalte_ausgewaehlter_lebensmittel.pdf
77. Bundesinstitut für Risikobewertung. BfRProgramm zur Bestimmung der Acrylamidaufnahme. http://www.bfr.bund.de/cd/8616acrylamidrechner.xlf
78. Perez HL, Cheong HK, Yang JS, Osterman-Golkar S (1999) Sumultaneous analysis of haemoglobin adducts or acrylamide and glycidamide by gas chromatography - mass spectrometry. Anal Biochem 274:59-68
79. Schettgen T, Weiss T, Drexler H, Angerer J (2003) A first approach to estimate the internal exposure to acrylamide in smoking and non-smoking adults from Germany. Int J Hyg Environ Health 206:9-14
80. Urban M, Kavvadias D, Riedel K, Scherer G (2006) Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers. Inhal Toxicol 18:831-839