The role of fast axonal transport in acrylamide pathophysiology: Mechanism or epiphenomenon?

NeuroToxicology

Volumn 23, Issue 2, 2002, Pages

  LoPachin, Richard M ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLAMIDE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM);

AXONAL INJURY; CONFERENCE PAPER; DEPOLARIZATION; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVE FIBER MEMBRANE POTENTIAL; NERVE FIBER TRANSPORT; NEUROTOXICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RETROGRADE NERVE FIBER TRANSPORT; ACTIVE TRANSPORT; ANIMAL; DRUG EFFECT; HUMAN; METABOLISM; NERVE FIBER; NOTE; PATHOLOGY; PHYSIOLOGY;

ACRYLAMIDE; ANIMALS; AXONAL TRANSPORT; AXONS; BIOLOGICAL TRANSPORT, ACTIVE; HUMANS;

EID: 0036632355     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-813X(02)00024-4     Document Type: Conference Paper

References (28)

1. M.B. Abou-Donia S.M. Ibrahim J.J. Corcoran L. Lac M.A. Friedman D.M. Lapadula Neurotoxicity of glycidamide, an acrylamide metabolite, following intraperitoneal injections in rats J. Toxicol. Environ. Health 3 1993 447 464
2. D.S. Barber J.R. Hunt M.F. Ehrich E.J. Lehning R.M. LoPachin Metabolism, toxicokinetics and hemoglobin adduct formation in rats following subacute and subchronic acrylamide dosing Neurotoxicology 22 2001 341 353
3. W.S. Brimijion P.I. Hammond Acrylamide neuropathy in the rat: effects on energy metabolism in sciatic nerve Mayo Clin. Proc. 60 1985 3 8
4. K.M. Crofton S. Padilla H.A. Tilson D.C. Anthony J.H. Raymer R.C. MacPhail The impact of dose-rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects Toxicol. Appl. Pharmacol. 139 1996 163 176
5. M. Erecinska I.A. Silver Ions and energy in mammalian brain Prog. Neurobiol. 43 1994 37 71
6. H.V. Gooodson S.J. Kang S.A. Endow Molecular physiogeny of the kinesin family of microtubule motor proteins J. Cell Sci. 107 1994 1875 1884
7. D.H. Hall F.M. Hedgecock Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C elegans Cell 65 1991 837 847
8. D.D. Hurd M. Stern W.M. Saxton Mutation of the axonal transport motor kinesin enhances paralytic and suppresses shaker in drosophila Genetics 142 1996 195 204
9. G.J. Lees Inhibition of sodium–potassium-ATPase: a potentially ubiquitous mechanism contributing to central nervous system neuropathology Brain Res. Rev. 16 1991 283 300
10. E.J. Lehning R.M. LoPachin J. Mathew J. Eichberg Changes in Na–K-ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats J. Toxicol. Environ. Health 42 1994 331 342
11. E.J. Lehning C.L. Gaughan J. Eichberg R.M. LoPachin Rubidium uptake and accumulation in peripheral myelinated internodal axons and Schwann cells J. Neurochem. 69 1997 968 977
12. E.J. Lehning C.L. Gaughan R.M. LoPachin Acrylamide intoxication modifies in vitro responses of peripheral nerve axons to anoxia J. Periph. Nerv. Syst. 2 1997 163 174
13. E.J. Lehning A. Persaud K.R. Dyer B.S. Jortner R.M. LoPachin Biochemical and morphologic characterization of acrylamide peripheral neuropathy Toxicol. Appl. Pharmacol. 151 1998 211 221
14. E.J. Lehning J.F. Ross A.S. Fix R.M. LoPachin Subacute acrylamide (ACR) exposure causes widespread synaptic terminal and cerebellar Purkinje cell degeneration in rat brain The Toxicologist 60 2001 366
15. R.M. LoPachin R.W. Moore L.A. Menahan R.E. Peterson Glucose-dependent lactate production by homogenates of neuronal tissues prepared from rats treated with 2,4-dithiobiuret, acrylamide, p -bromophenylacetylurea and 2,5-hexanedione Neurotoxicology 5 1984 25 36
16. R.M. LoPachin C.M. Castiglia A.J. Saubermann Acrylamide disrupts elemental composition and water content of rat tibial nerve. Part I. Myelinated axons Toxicol. Appl. Pharmacol. 115 1992 21 34
17. R.M. LoPachin E.J. Lehning Acrylamide-induced distal axon degeneration: a proposed mechanism of neurotoxicity Neurotoxicology 15 1994 247 260
18. R.M. LoPachin E.J. Lehning Mechanisms of calcium entry during axon injury and degeneration Toxicol. Appl. Pharmacol. 143 1997 233 244
19. R.M. LoPachin E.J. Lehning L.A. Opanashuk B.S. Jortner Rate of neurotoxicant exposure determines morphologic manifestations of distal axonopathy Toxicol. Appl. Pharmacol. 167 2000 233 244
20. C.J. Medrano R.M. LoPachin Effects of acrylamide and 2,5-hexanedione on brain mitochondrial respiration Neurotoxicology 10 1989 249 256
21. D.J. O’Shaughnessy G.J. Losos Comparison of central and peripheral nervous system lesions caused by high-dose short-term and low-dose subchronic acrylamide treatment in rats Toxicol. Pathol. 14 1986 389 394
22. K.K. Pfister M.C. Wagner G.S. Bloom S.T. Brady Modification of the microtubules-binding and ATPase activities of kinesin by N -etheylmaleimide (NEM) suggests role of sulfhydryls in fast axonal transport Biochemistry 28 1989 9006 9012
23. J. Sakamoto K. Hashimoto Effects of acrylamide and related compounds on glycolytic enzymes in rat sciatic nerve in vivo Arch. Toxicol. 57 1985 282 284
24. D.W. Sickles S.R. Fowler A.R. Testino Effects of neurofilamentous axonopathy-producing neurotoxicants on in vitro production of ATP by brain mitochondria Brain Res. 528 1990 25 31
25. P.S. Spencer H.H. Schaumburg A review of acrylamide neurotoxicity. Part II. Experimental animal neurotoxicity and pathologic mechanisms Can. J. Neurol. Sci. 1 1974 170 192
26. P.K. Stys Anoxic and ischemic injury of myelinated axons in CNS white matter: from mechanistic concepts to therapeutics J. Cereb. Blood Flow Metab. 18 1998 2 25
27. B.F. Trump I.K. Berezesky S.H. Chang R.E. Pendergrass W.J. Mergner The role of ion shifts in cell injury Scand. Electron. Microsc. III 1979 1 14
28. S. Yoshimura K. Imai Y. Saitoh H. Yamaguchi S. Ohtaki The same chemicals induce different neurotoxicity when administered in high-doses for short-term or low-doses for long-term to rats and dogs Mol. Chem. Neuropathol. 16 1992 59 83