Down-regulation of Wnt signaling could promote bone marrow-derived mesenchymal stem cells to differentiate into hepatocytes

Biochemical and Biophysical Research Communications

Volumn 367, Issue 2, 2008, Pages 342-348

  Ke, Zunfu ^a,b   Zhou, Feng ^a,b   Wang, Liantang ^a,b   Chen, Shaohong ^a,b   Liu, Fang ^a,b   Fan, Xinjuan ^a,b   Tang, Fang ^a,b   Liu, Dawei ^a,b   Zhao, Guoqiang ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Catenin; Adult stem cell; Directing differentiation; Hepatocyte; Mesenchymal stem cell; Wnt

Indexed keywords

ALBUMIN; BETA CATENIN; DISHEVELLED PROTEIN; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; LIVER EXTRACT; MEMBRANE ANTIGEN; MESSENGER RNA; WNT PROTEIN; WNT1 PROTEIN; WNT5A PROTEIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; LIVER CELL; LIVER INJURY; MALE; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; HEPATOCYTES; MALE; MESENCHYMAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; WNT PROTEINS;

EID: 38349047718     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.12.134     Document Type: Article

References (35)

1. Kashofer K., and Bonnet D. Gene therapy progress and prospects: stem cell plasticity. Gene Ther. 12 (2005) 1229-1234
2. Krause D.S., Theise ND., Collector MI., Henegariu O., Hwang S., Gardner R., Neutzel S., and Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105 (2001) 369-377
3. Lee K.D., Kuo T.K., Whang-Peng J., Chung Y.F., Lin C.T., Chou S.H., Chen J.R., Chen Y.P., and Lee O.K. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 40 (2004) 1275-1284
4. Hong S.H., Gang E.J., Jeong J.A., Ahn C., Hwang S.H., Yang I.H., Park H.K., Han H., and Kim H. In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem. Biophys. Res. Commun. 330 (2005) 1153-1161
5. Hong H., Chen J.Z., Zhou F., Xue L., and Zhao G.Q. Influence of serum from liver-damaged rats on differentiation tendency of bone marrow-derived stem cells. World J. Gastroenterol. 15 (2004) 2250-2253
6. Cadigan K.M., and Nusse R. Wnt signalling: a common theme in animal development. Genes 11 (1997) 3286-3305
7. Garcia-Castro M.I., Marcelle C., and Bronner-Fraser M. Ectodermal Wnt function as a neural crest inducer. Science 297 (2002) 848-851
8. He X., Semënov M., Tamai K., and Zeng X. LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: arrows point the way. Development 131 (2004) 1663-1677
9. Hurlstone A., and Clevers H. T-cell factors: turn-ons and turn-offs. EMBO J. 21 (2002) 2303-2311
10. He T.C., Sparks A.B., Rago C., Hermeking H., Zawel L., Morin P.J., Vogelstein B., and Kinzler KW. Identification of c-MYC as a target of the APC pathway. Science 281 (1998) 1509-1512
11. Tetsu O., and McCormick F. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398 (1999) 422-426
12. Lowry W.E., Blanpain C., Nowak J.A., Guasch G., Lewis L., and Fuchs E. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells. Genes 19 (2005) 1596-1611
13. Woodward W.A., Chen M.S., Behbod F., and Rosen J.M. On mammary stem cells. J. Cell. Sci. 118 (2005) 3585-3594
14. Reya T., Duncan A.W., Ailles L., Domen J., Scherer D.C., Willert K., Hintz L., Nusse R., and Weissman I.L. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423 (2003) 409-414
15. Schilling T., Nöth U., Klein-Hitpass L., Jakob N., and Schütze F. Plasticity in adipogenesis and osteogenesis of human mesenchymal stem cells. Mol. Cell Endocrinol. 271 (2007) 1-17
16. Hou M., Yang K.M., Zhang H., Zhu W.Q., Duan F.J., and Wang H. Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats. J. Int. Cardiol. 115 (2007) 220-228
17. Oh S.H., Witek R.P., Bae S.H., Zheng D., Jung Y., and Piscaglia A.C. Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration. Gastroenterology 132 (2007) 1077-1087
18. Oyagi S., Hirose M., Kojima M., Okuyama M., Kawase M., and Nakamura T. Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats. J. Hepatol. 44 (2006) 742-748
19. Podestà M., Benvenuto F., Pitto A., Figari O., Bacigalupo A., Bruzzone S., Guida L., Franco L., Paleari L., Bodrato N., Usai C., De Flora A., and Zocchi E. Concentrative uptake of cyclic ADP-ribose generated by BST-1+ stroma stimulates proliferation of human hematopoietic progenitors. J. Biol. Chem. 280 (2005) 5343-5349
20. Weinhouse S. A single GST-P positive hepatocyte induced by a hepatocarcinogen. Jpn. J. Cancer. Res. 82 (1991) 1464-1465
21. Lee S.J., Friedman S.L., Whalen R., and Boyer T.D. Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: localization by in situ hybridization. Biochem. J. 299 (1994) 79-83
22. Parent R., Marion M.J., Furio L., Trépo C., and Petit M.A. Origin and characterization of a human bipotent liver progenitor cell line. Gastroenterology 126 (2004) 1147-1156
23. Tee L.B., Kirilak Y., Huang W.H., Smith P.G., Morgan R.H., and Yeoh G.C. Dual phenotypic expression of hepatocytes and bile ductular markers in developing and preneoplastic rat liver. Carcinogenesis 17 (1996) 251-259
24. Nowak G., Ericzon B.G., Nava S., Jaksch M., Westgren M., and Sumitran-Holgersson S. Identification of expandable human hepatic progenitors which differentiate into mature hepatic cells in vivo. Gut 54 (2005) 972-979
25. Alonso L., and Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes 17 (2003) 1189-1200
26. Sancho E., Batlle E., and Clevers H. Live and let die in the intestinal epithelium. Curr. Opin. Cell. Biol. 15 (2003) 763-770
27. Yoshida Y., Shimomura T., Sakabe T., Ishii K., Gonda K., Matsuoka S., Watanabe Y., Takubo K., Tsuchiya H., Hoshikawa Y., Kurimasa A., Hisatome I., Uyama T., Terai M., Umezawa A., and Shiota G. A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. Am. J. Physiol. Gastrointest. Liver Physiol. 293 (2007) 1089-1098
28. Reya T. Regulation of hematopoietic stem cell self-renewal. Recent Prog. Horm. Res. 58 (2003) 283-295
29. Willert K., Brown J.D., Danenberg E., Duncan A.W., Weissman I.L., Reya T., Yates J.R., and Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423 (2003) 448-452
30. Kielman M.F., Rindapaa M., Gaspar C., van Poppel N., Breukel C., van Leeuwen S., Taketo M.M., Roberts S., Smits R., and Fodde R. Apc modulates embryonic stem-cell differentiation by controlling the dosage of b-catenin signaling. Nat. Genet. 32 (2002) 594-605
31. Haegele L., Ingold B., Naumann H., Tabatabai G., Ledermann B., and Brandner S. Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression. Mol. Cell. Neurosci. 24 (2003) 696-708
32. Aubert J., Dunstan H., Chambers I., and Smith A. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat. Biotechnol. 20 (2002) 1240-1245
33. Chu E.Y., Hens J., Andl T., Kairo A., Yamaguchi T.P., Brisken C., Glick A., Wysolmerski J.J., and Millar S.E. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development 131 (2004) 4819-4829
34. Davidson G., Mao B.Y., Barrantes I.D., and Niehrs C. Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. Development 129 (2002) 5587-5596
35. Willert K., and Nusse R. Beta-catenin: a key mediator of Wnt signaling. Curr. Opin. Genet. Dev. 8 (1998) 95-102