Conversion of CD95 (Fas) Type II into Type I signaling by sub-lethal doses of cycloheximide

Experimental Cell Research

Volumn 314, Issue 3, 2008, Pages 554-563

  Brumatti, G ^a,b   Yon, M ^a,b   Castro, F A ^a,b   Bueno da Silva, A E B ^a,b   Jacysyn, J F ^a,b   Brunner, T ^d   Amarante Mendes, G P ^a,b,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Instituto de Investigação em Imunologia   (Brazil)

^c INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Apoptosis; Bcl 2; Bid; CD95; Cycloheximide; Fas; FLIP; Type I; Type II

Indexed keywords

CASPASE 3; CASPASE 8; CYCLOHEXIMIDE; CYTOCHROME C; ETOPOSIDE; FAS ANTIGEN; PROTEIN BCL 2; STAUROSPORINE; VINCRISTINE;

APOPTOSIS; ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

EID: 38349042540     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.11.003     Document Type: Article

References (35)

1. Amarante-Mendes G.P., and Green D.R. The regulation of apoptotic cell death. Braz. J. Med. Biol. Res. 32 (1999) 1053-1061
2. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
3. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Snow B.E., Brothers G.M., Mangion J., Jacotot E., Costantini P., Loeffler M., Larochette N., Goodlett D.R., Aebersold R., Siderovski D.P., Penninger J.M., and Kroemer G. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397 (1999) 441-446
4. Li L.Y., Luo X., and Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412 (2001) 95-99
5. Huang K.J., Ku C.C., and Lehman I.R. Endonuclease G: a role for the enzyme in recombination and cellular proliferation. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 8995-9000
6. Du C., Fang M., Li Y., Li L., and Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102 (2000) 33-42
7. Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J., and Vaux D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102 (2000) 43-53
8. Suzuki Y., Takahashi-Niki K., Akagi T., Hashikawa T., and Takahashi R. Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ. 11 (2004) 208-216
9. Schulze-Osthoff K., Ferrari D., Los M., Wesselborg S., and Peter M.E. Apoptosis signaling by death receptors. Eur. J. Biochem. 254 (1998) 439-459
10. Kischkel F.C., Hellbardt S., Behrmann I., Germer M., Pawlita M., Krammer P.H., and Peter M.E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14 (1995) 5579-5588
11. Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.M., Krammer P.H., and Peter M.E. Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17 (1998) 1675-1687
12. Luo X., Budihardjo I., Zou H., Slaughter C., and Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94 (1998) 481-490
13. Li H., Zhu H., Xu C.J., and Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998) 491-501
14. Fulda S., Meyer E., and Debatin K.M. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res. 60 (2000) 3947-3956
15. Scaffidi C., Schmitz I., Zha J., Korsmeyer S.J., Krammer P.H., and Peter M.E. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem. 274 (1999) 22532-22538
16. L following diverse apoptogenic stimuli. FEBS Lett. 541 (2003) 57-63
17. Nicoletti I., Migliorati G., Pagliacci M.C., Grignani F., and Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139 (1991) 271-279
18. Finucane D.M., Waterhouse N.J., Amarante-Mendes G.P., Cotter T.G., and Green D.R. Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL60 cells. Exp. Cell Res. 251 (1999) 166-174
19. Bueno-da-Silva A.E., Brumatti G., Russo F.O., Green D.R., and Amarante-Mendes G.P. Bcr-Abl-mediated resistance to apoptosis is independent of constant tyrosine-kinase activity. Cell Death Differ. 10 (2003) 592-598
20. Fulda S., Meyer E., Friesen C., Susin S.A., Kroemer G., and Debatin K.M. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 20 (2001) 1063-1075
21. Fulda S., Kufer M.U., Meyer E., van Valen F., Dockhorn-Dworniczak B., and Debatin K.M. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 20 (2001) 5865-5877
22. L inhibits cytochrome c release but not mitochondrial depolarization during the activation of multiple death pathways by tumor necrosis factor-alpha. J. Biol. Chem. 275 (2000) 31546-31553
23. Bossy-Wetzel E., and Green D.R. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors. J. Biol. Chem. 274 (1999) 17484-17490
24. Luthi A.U., and Martin S.J. The CASBAH: a searchable database of caspase substrates. Cell Death Differ. 14 (2007) 641-650
25. Peter M.E., and Krammer P.H. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis. Curr. Opin. Immunol. 10 (1998) 545-551
26. Muzio M., Salvesen G.S., and Dixit V.M. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens. J. Biol. Chem. 272 (1997) 2952-2956
27. L-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. J. Biol. Chem. 277 (2002) 4351-4360
28. Jeon Y.K., Kim H., Park S.O., Choi H.Y., Kim Y.A., Park S.S., Kim J.E., Kim Y.N., and Kim C.W. Resistance to Fas-mediated apoptosis is restored by cycloheximide through the downregulation of cellular FLIPL in NK/T-cell lymphoma. Lab. Invest. 85 (2005) 874-884
29. Kreuz S., Siegmund D., Scheurich P., and Wajant H. NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 21 (2001) 3964-3973
30. Van Antwerp D.J., Martin S.J., Kafri T., Green D.R., and Verma I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274 (1996) 787-789
31. Yin X.M., Wang K., Gross A., Zhao Y., Zinkel S., Klocke B., Roth K.A., and Korsmeyer S.J. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400 (1999) 886-891
32. Scheel-Toellner D., Wang K., Singh R., Majeed S., Raza K., Curnow S.J., Salmon M., and Lord J.M. The death-inducing signalling complex is recruited to lipid rafts in Fas-induced apoptosis. Biochem. Biophys. Res. Commun. 297 (2002) 876-879
33. Eramo A., Sargiacomo M., Ricci-Vitiani L., Todaro M., Stassi G., Messina C.G., Parolini I., Lotti F., Sette G., Peschle C., and De Maria R. CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells. Eur. J. Immunol. 34 (2004) 1930-1940
34. Aouad S.M., Cohen L.Y., Sharif-Askari E., Haddad E.K., Alam A., and Sekaly R.P. Caspase-3 is a component of Fas death-inducing signaling complex in lipid rafts and its activity is required for complete caspase-8 activation during Fas-mediated cell death. J. Immunol. 172 (2004) 2316-2323
35. Legembre P., Daburon S., Moreau P., Moreau J.F., and Taupin J.L. Modulation of Fas-mediated apoptosis by lipid rafts in T lymphocytes. J. Immunol. 176 (2006) 716-720