The D-diastereomer of ShK toxin selectively blocks voltage-gated K + channels and inhibits T lymphocyte proliferation

Journal of Biological Chemistry

Volumn 283, Issue 2, 2008, Pages 988-997

  Beeton, Christine ^a   Smith, Brian J ^b   Sabo, Jennifer K ^b   Crossley, George ^c   Nugent, Daniel ^c   Khaytin, Ilya ^c   Chi, Victor ^a   Chandy, K George ^a   Pennington, Michael W ^c   Norton, Raymond S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c Bachem Holding AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN EFFECTOR MEMORY; LYMPHOCYTE PROLIFERATION; RHEUMATOID ARTHRITIS;

AMINO ACIDS; CELL PROLIFERATION; DISEASES; PLASMA (HUMAN); POLYPEPTIDES; PROTEOLYSIS;

TOXIC MATERIALS;

PROTEIN SHK; TOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CELL PROLIFERATION; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; SYNTHESIS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; CELL DIVISION; CNIDARIAN VENOMS; HUMANS; IMMUNOLOGIC MEMORY; KINETICS; KV1.3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; T-LYMPHOCYTES;

EID: 38149095036     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M706008200     Document Type: Article

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