Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers

Nature

Volumn 430, Issue 6996, 2004, Pages 235-240

  Suchyna, Thomas M ^a   Tape, Sonya E ^b   Koeppe II, Roger E ^c   Andersen, Olaf S ^b   Sachs, Frederick ^a   Gottlieb, Philip A ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF ARKANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ECOSYSTEMS; HYDROLYSIS; HYDROPHOBICITY; ORGANIC COMPOUNDS;

BILAYERS; PEPTIDES;

NEUROLOGY;

ION CHANNEL; SPIDER VENOM; UNCLASSIFIED DRUG; VENOM PEPTIDE GSMTX4;

MEDICINE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BILAYER MEMBRANE; CHICKEN; EMBRYO; ENANTIOMER; HEART MUSCLE CELL; HYDROPHOBICITY; NERVE CELL CULTURE; NONHUMAN; PARTITION COEFFICIENT; PATCH CLAMP; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; SPIDER; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ASTROCYTES; CATIONS; CHICKENS; ELECTRIC CONDUCTIVITY; GRAMICIDIN; ION CHANNEL GATING; ION CHANNELS; LIPID BILAYERS; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; PEPTIDES; RATS; SPIDER VENOMS; STEREOISOMERISM;

ANIMALIA; ARANEAE; GALLUS GALLUS; GRAMMOSTOLA SPATULATA;

EID: 3142652571     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02743     Document Type: Article

References (29)

1. Suchyna, T. M. et al. Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J. Gen. Physiol. 115, 583-598 (2000).
2. Andersen, O. S. et al. Ion channels as tools to monitor lipid bilayer-membrane protein interactions: gramicidin channels as molecular force transducers. Methods Enzymol. 294, 208-224 (1999).
3. + channels. Nature Neurosci. 2, 422-426 (1999).
4. + channels. Curr. Opin. Cell Biol. 13, 422-427 (2001).
5. Perozo, E., Kloda, A., Cortes, D. M. & Martinac, B. Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating. Nature Struct. Biol. 9, 696-703 (2002).
6. Lundbæk, J. A. & Andersen, O. S. Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers. J. Gen. Physiol. 104, 645-673 (1994).
7. Hwang, T. C., Koeppe, R. E. II & Andersen, O. S. Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics. Biochemistry 42, 13646-13658 (2003).
8. Goulian, M. et al. Gramicidin channel kinetics under tension. Biophys. J. 74, 328-337 (1998).
9. Oswald, R. E., Suchyna, T. M., McFeeters, R., Gottlieb, P. & Sachs, F. Solution structure of peptide toxins that block mechanosensitive ion channels. J. Biol. Chem. 277, 34443-34450 (2002).
10. Ostrow, K. L. et al. cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels. Toxicon 42, 263-274 (2003).
11. Markin, V. S. & Sachs, F. Thermodynamics of mechanosensitivity. Physical Biol. (in the press).
12. Suchyna, T. & Sachs, F. Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time. Phys. Biol. 1, 1-18 (2004).
13. Ladokhin, A. S., Jayasingbe, S. & White, S. H. How to measure and analyze tryptophan fluorescence in membranes properly, and why bother? Anal. Biochem. 285, 235-245 (2000).
14. White, S. H., Wimley, W. C., Ladokhin, A. S. & Hristova, K. Protein folding in membranes: determining energetics of peptide-bilayer interactions. Methods Enzymol. 295, 62-87 (1998).
15. Kim, J., Mosior, M., Chung, L. A., Wu, H. & McLaughlin, S. Binding of peptides with basic residues to membranes containing acidic phospholipids. Biophys. J. 60, 135-148 (1991).
16. Lundbæk, J. A. & Andersen, O. S. Spring constants for channel-induced lipid bilayer deformations-estimates using gramicidin channels. Biophys. J. 76, 889-895 (1999).
17. O'Connell, A. M., Koeppe, R. E. II & Andersen, O. S. Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association. Science 250, 1256-1259 (1990).
18. Elliott, J. R., Needham, D., Dilger, J. P. & Haydon, D. A. The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochim. Biophys. Acta 735, 93-103 (1983).
19. Huang, H. W. Deformation free energy of bilayer membrane and its effect on gramicidin channel lifetime. Biophys. J. 50, 1061-1070 (1986).
20. Koeppe, R. E. II et al. On the helix sense of gramicidin A single channels. Proteins 12, 49-62 (1992).
21. 9,11,13,15 gramicidin A. Int. J. Pept. Protein Res. 30, 163-169 (1987).
22. Lundbæk, J. A. et al. Regulation of sodium channel function by bilayer elasticity the importance of hydrophobic coupling: effects of micelle-forming amphiphiles and cholesterol. J. Gen. Physiol. 123, 599-621 (2004).
23. Bode, F., Sachs, F. & Franz, M. R. Tarantula peptide inhibits atrial fibrillation. Nature 409, 35-36 (2001).
24. Lehtonen, J. Y. & Kinnunen, P. K. Phospholipase A2 as a mechanosensor. Biophys. J. 68, 1888-1894 (1995).
25. Gudi, S., Nolan, J. P. & Frangos, J. A. Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition. Proc. Natl Acad. Sci. USA 95, 2515-2519 (1998).
26. Laitko, U. & Morris, C. E. Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel. J. Gen. Physiol. 123, 135-154 (2004).
27. Greathouse, D. V., Koeppe, R. E. II, Providence, L. L., Shobana, S. & Andersen, O. S. Design and characterization of gramicidin channels. Methods Enzymol. 294, 525-550 (1999).
28. Andersen, O. S. Ion movement through gramicidin A channels. Single-channel measurements at very high potentials. Biophpys J. 41, 119-133 (1983).
29. Bett, G. C. & Sachs, F. Activation and inactivation of mechanosensitive currents in the chick heart. J. Membr. Biol. 173, 237-254 (2000).