Lymphoid neogenesis in chronic rejection

Current Opinion in Organ Transplantation

Volumn 13, Issue 1, 2008, Pages 16-19

  Thaunat, Olivier ^a,b,c   Nicoletti, Antonino ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

Author keywords

Chronic rejection; Ectopic germinal center; Lymphoid neogenesis; Pathophysiology; Tertiary lymphoid organ; Transplantation

Indexed keywords

ALLOIMMUNITY; ANTIGEN PRESENTATION; CHRONIC GRAFT REJECTION; GERMINAL CENTER; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; LYMPHANGIOGENESIS; LYMPHOID CELL; PATHOGENESIS; PATHOPHYSIOLOGY; REVIEW; TISSUE GRAFT;

ANTIBODY FORMATION; GERMINAL CENTER; GRAFT REJECTION; HUMANS; LYMPHANGIOGENESIS; LYMPHOID TISSUE; RECEPTOR CROSS-TALK; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTS;

EID: 38149031779     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3282f3df15     Document Type: Review

References (30)

1. Sayegh MH, Carpenter CB. Transplantation 50 years later: progress, challenges, and promises. N Engl J Med 2004; 351:2761-2766.
2. Prineas JW. Multiple sclerosis: presence of lymphatic capillaries and lymphoid tissue in the brain and spinal cord. Science 1979; 203:1123-1125.
3. Drayton DL, Liao S, Mounzer RH, Ruddle NH. Lymphoid organ development: from ontogeny to neogenesis. Nat Immunol 2006; 7:344-353. This work provides an up-to-date review of the recent advances obtained in the field of lymphoid organogenesis and lymphoid neogenesis. Similarities and differences between ectopic and professional secondary lymphoid organs are discussed.
4. Kratz A, Campos-Neto A, Hanson MS, Ruddle NH. Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J Exp Med 1996; 183:1461-1472.
5. Nasr IW, Reel M, Oberbarnscheidt MH, et al. Tertiary lymphoid tissues generate effector and memory T cells that lead to allograft rejection. Am J Transplant 2007; 7:1071-1079.
6. Armengol MP, Juan M, Lucas-Martin A, et al. Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol 2001; 159:861-873.
7. Schroder AE, Greiner A, Seyfert C, Berek C. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 1996; 93:221-225.
8. Aloisi F, Pujol-Borrell R. Lymphoid neogenesis in chronic inflammatory diseases. Nat Rev Immunol 2006; 6:205-217. A comprehensive review of lymphoid neogenesis associated with chronic inflammatory diseases.
9. Joshi A, Masek MA, Brown BW, et al. 'Quilty' revisited: a 10-year perspective. Hum Pathol 1995; 26:547-557.
10. Chu KE, Ho EK, de la Torre L, et al. The relationship of nodular endocardial infiltrates (Quilty lesions) to survival, patient age, anti-HLA antibodies, and coronary artery disease following heart transplantation. Cardiovasc Pathol 2005; 14:219-224.
11. Joshi A, Masek MA, Brown BW Jr, et al. 'Quilty' revisited: a 10-year perspective. Hum Pathol 1995; 26:547-557.
12. Luthringer DJ, Yamashita JT, Czer LS, et al. Nature and significance of epicardial lymphoid infiltrates in cardiac allografts. J Heart Lung Transplant 1995; 14:537-543.
13. Smith RN, Chang Y, Houser S, et al. Higher frequency of high-grade rejections in cardiac allograft patients after Quilty B lesions or grade 2/4 rejections. Transplantation 2002; 73:1928-1932.
14. Yamani MH, Ratliff NB, Starling RC, et al. Quilty lesions are associated with increased expression of vitronectin receptor (alphavbeta3) and subsequent development of coronary vasculopathy. J Heart Lung Transplant 2003; 22:687-690.
15. Kerjaschki D, Regele HM, Moosberger I, et al. Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 2004; 15:603-612.
16. Thaunat O, Field AC, Dai J, et al. Lymphoid neogenesis in chronic rejection: evidence for a local humoral alloimmune response. Proc Natl Acad Sci U S A 2005; 102:14723-14728.
17. Muramatsu M, Sankaranand VS, Anant S, et al. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem 1999; 274:18470-18476.
18. Walker LS, Gulbranson-Judge A, Flynn S, et al. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol Today 2000; 21:333-337.
19. Baddoura FK, Nasr IW, Wrobel B, et al. Lymphoid neogenesis in murine cardiac allografts undergoing chronic rejection. Am J Transplant 2005; 5:510-516.
20. Eberl G, Marmon S, Sunshine MJ, et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 2004; 5:64-73.
21. Mebius RE. Organogenesis of lymphoid tissues. Nat Rev Immunol 2003; 3:292-303.
22. Thaunat O, Patey N, Morelon E, et al. Lymphoid neogenesis in chronic rejection: the murderer is in the house. Curr Opin Immunol 2006; 18:576-579. The authors summarized the findings of refs [15,16]: ectopic germinal centers are present within human allografts (hearts and kidneys) chronically rejected; and the involvement of lymphoid neogenesis in the rejection process is suggested by the demonstration of a local production of alloantibodies.
23. Thaunat O, Kerjaschki D, Nicoletti A. Is defective lymphatic drainage a trigger for lymphoid neogenesis? Trends Immunol 2006; 27:441-445. The authors review the evidence linking lymphoid neogenesis and lymphangiogenesis during chronic inflammation.
24. Ruggiero R, Fietsam R Jr, Thomas GA, et al. Detection of canine allograft lung rejection by pulmonary lymphoscintigraphy. J Thorac Cardiovasc Surg 1994; 108:253-258.
25. Angeli V, Ginhoux F, Llodra J, et al. B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization. Immunity 2006; 24:203-215. First evidence that B cells, upon activation, influence the remodeling of the lymphatic network.
26. Ochando JC, Homma C, Yang Y, et al. Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts. Nat Immunol 2006; 7:652-662.
27. Capello D, Rossi D, Gaidano G. Posttransplant lymphoproliferative disorders: molecular basis of disease histogenesis and pathogenesis. Hematol Oncol 2005; 23:61-67.
28. Tanaka M, Zwierzchoniewska M, Mokhtari GK, et al. Progression of alloresponse and tissue-specific immunity during graft coronary artery disease. Am J Transplant 2005; 5:1286-1296.
29. Higgins CD, Swerdlow AJ, Smith JD, et al. Risk of lymphoid neoplasia after cardiothoracic transplantation: the influence of underlying disease and human leukocyte antigen type and matching. Transplantation 2003; 75:1698-1703.
30. Rose ML. Activation of autoimmune B cells and chronic rejection. Transplantation 2005; 79:S22-S24.