Changes in redox ratio and protein glycation in precataractous lens from fructose-fed rats: Effects of exogenous L-carnitine

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 2, 2008, Pages 168-173

  Balasaraswathi, K ^a   Rajasekar, P ^a   Anuradha, C V ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Carnitine; Fructose; Glycation; Lens; Oxidative stress

Indexed keywords

CARNITINE; FRUCTOSE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; HOMEOSTASIS; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PROTEIN GLYCOSYLATION; RAT; SUGAR INTAKE;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CARNITINE; CATALASE; CATARACT; DIETARY CARBOHYDRATES; DISEASE MODELS, ANIMAL; FRUCTOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLYCOSYLATION; INSULIN; INSULIN RESISTANCE; LENS, CRYSTALLINE; LIPID PEROXIDATION; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 38149029024     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04815.x     Document Type: Article

References (39)

1. Rajasekar P, Kaviarasan S, Anuradha CV. l-Carnitine administration prevents oxidative stress in high fructose-fed insulin resistant rats. Diabetol. Croat. 2005 34: 21 8.
2. Faure P, Rossini E, Lafond JL, Richard MJ, Favier A, Halimi S. Vitamin E improves the free radical defense system potential and insulin sensitivity of rats fed high fructose diets. J. Nutr. 1997 127: 103 7.
3. Anitha Nandhini AT, Balakrishnan SD, Anuradha CV. Response of liver antioxidant system to taurine in rats fed high fructose diet. Ind. J. Exp. Biol. 2002 40: 1016 19.
4. Anitha Nandhinia AT, Thirunavukkarasu V, Ravichandran MK, Anuradha CV. Taurine prevents fructose-diet induced collagen abnormalities in rat skin. J. Diabetes Comp. 2005 19: 305 11.
5. Thirunavukkarasu V, Anitha Nandhini AT, Anuradha CV. Lipoic acid prevents collagen abnormalities in tail tendon of high fructose-fed rats. Diabetes Obesity Metab. 2005 7: 294 7.
6. Perry RE, Swamy MS, Abraham EC. Progressive changes in lens crystallin glycation and high-molecular-weight aggregate formation leading to cataract development in streptozotocin-diabetic rats. Exp. Eye Res. 1987 44: 269 82.
7. Srivastava Y, Venkatakrishna-Bhatt H, Verma Y. Effect of Momordica charantia Linn. pomous aqueous extract on cataractogenesis in murrin alloxan diabetics. Pharmacol. Res. Commun. 1988 20: 201 9.
8. Stevens VJ, Rouzer CA, Monnier VM, Cerami A. Diabetic cataract formation: Potential role of glycosylation of lens crystallins. Proc. Natl Acad. Sci. USA 1978 75: 2918 22.
9. Tamamogullari N, Silig Y, Icagasioglu S, Atalay A. Carnitine deficiency in diabetes mellitus complications. J. Diabetes Complications 1999 13: 251 3.
10. Nakamura J, Koh N, Sakakibara F et al. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabeticrats. J. Pharmacol. Exp. Ther. 1998 287: 897 902.
11. Rajasekar P, Ravichandran MK, Anuradha CV. Intraperitoneal l-carnitine regulates lipid metabolism and reduces oxidative stress in fructose-induced hyperlipidemic rats. Diabetol. Croat. 2006 34: 87 95.
12. Anitha Nandhini AT, Balakrishnan SD, Anuradha CV. Taurine modulates antioxidant potential and controls lipid peroxidation in the aorta of high fructose-fed rats. J. Biochem. Mol. Biol. Biophys. 2002 6: 129 33.
13. Levine RL, Garland D, Oliver CN et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990 186: 464 78.
14. Dillard CJ, Tappel AL. Fluorescent damage products of lipid peroxidation. Methods Enzymol. 1984 105: 337 41.
15. Ellman GL. Tissue sulphydryl groups. Arch. Biochem. Biophys. 1959 82: 70 7.
16. Teitze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 1969 27: 502 22.
17. Friedemann TE, Haugen GE. The determination of keto acids in blood and urine. J. Biol. Chem. 1943 147: 415 42.
18. Barker SB, Summerson WH. The colorimetric determination of lactic acid in biological material. J. Biol. Chem. 1941 138: 535 54.
19. Gerlack U, Hibby W. Sorbitol dehydrogenase. In: Bergmeyer HU (ed.). Methods of Enzymatic Analysis, Vol. 2. Academic Press, New York. 1974 569 73.
20. Roe JH. A colorimetric method for the determination of fructose in blood and urine. J. Biol. Chem. 1934 107: 15 22.
21. Rao P, Pattabiraman TN. Further studies on the mechanism of phenol-sulfuric acid reaction with furaldehyde derivatives. Anal. Biochem. 1990 189: 178 81.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with Folin's phenol reagent. J. Biol. Chem. 1951 193: 265 75.
23. Awasthi S, Srivatava SK, Piper JT, Singhal SS, Chaubey M, Awasthi YC. Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. Am. J. Clin. Nutr. 1996 64: 761 6.
24. Ansari NH, Wang L, Srivastava SK. Role of lipid aldehydes in cataractogenesis: 4-Hydroxynonenal-induced cataract. Biomed. Mol. Med. 1996 58: 25 30.
25. Cheng HM, Cheng FY, Xiong H, Xiong J. The further metabolism of sorbitol-3-phosphate and fructose-3-phosphate in the mature rat lens. Ophthalmic Res. 1996 28: 57 63.
26. Lal S, Szwergold BS, Taylor AH et al. Metabolism of fructose-3-phosphate in the diabetic rat lens. Arch. Biochem. Biophys. 1995 318: 191 9.
27. Levi B, Werman MJ. Fructose and related phosphate derivatives impose DNA damage and apoptosis in L5178Y mouse lymphoma cells. J. Nutr. Biochem. 2003 14: 49 60.
28. Herbert KL, Sivak JG, Bell RC. Effect of diabetes and fructose/non-fructose diet on the optical quality (cataracts) of the rat lens. Curr. Eye Res. 1999 19: 305 12.
29. McPherson JD, Shilton BH, Walton DJ. Role of fructose in glycation and cross-linking of proteins. Biochemistry 1988 27: 1901 7.
30. Jedziniak JA, Chylack LT, Cheng HM, Gillis MK, Kalustian AA, Tung WH. The sorbitol pathway in the human lens: Aldose reductase and polyol dehydrogenase. Invest. Ophthalmol. Vis. Sci. 1981 20: 314 26.
31. Bell RC, Carlson JC, Storr KC, Herbert K, Sivak J. High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. Br. J. Nutr. 2000 84: 575 82.
32. Hedge KR, Varma SD. Protective effect of ascorbate against oxidative stress in the mouse lens. Biochim. Biophys. Acta 2004 1670: 12 18.
33. Obrosova I, Cao X, Greene DA, Stevens MJ. Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: Effect of dl-alpha-lipoic acid. Diabetologia 1998 41: 1442 50.
34. Reznick AZ, Kagan VE, Ramsey R et al. Antiradical effects in l-propionyl carnitine, protection of the heart against ischemia-reperfusion injury: The possible role of iron chelation. Arch. Biochem. Biophys. 1992 296: 394 401.
35. Khairallah EA, Wolf G. Growth-promoting and lipotropic effect of carnitine in rats fed diet limited in protein and methionine. J. Nutr. 1984 87: 469 76.
36. Arduini A. Carnitine and its acyl esters as secondary antioxidants? Am. Heart. J. 1992 123: 1726 7.
37. Rajasekar P, Anuradha CV. l-Carnitine inhibits protein glycation in vitro and in vivo: Evidence for a role in diabetic management. Acta Diabetol. 2007 44: 83 90.
38. Peluso G, Petillo O, Barbarisi A et al. Carnitine protects the molecular chaperone activity of lens α-crystallin and decreases the posttranslational protein modifications induced by oxidative stress. FASEB 2001 15: 1604 6.
39. Swamy-Mruthinti S, Carter AL. Acetyl-carnitine decreases glycation of lens proteins: In vitro studies. Exp. Eye Res. 1999 69: 109 15.