The Further Metabolism of Sorbitol-3-Phosphate and Fructose-3-Phosphate in the Mature Rat Lens

Ophthalmic Research

Volumn 28, Issue 1, 1996, Pages 57-63

  Hazlett, Hong Ming ^a   Cheng, Felix Y ^a   Xiong, Hua ^a   Jing, Jing ^a  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

Diabetes; Fructose 3 phosphate; Glucose metabolism; Mature rat lens; NMR spectroscopy; Sorbitol 3 phosphate

Indexed keywords

FRUCTOSE PHOSPHATE; GLYCEROPHOSPHATE; LACTIC ACID; SORBITOL; FRUCTOSE 3 PHOSPHATE; FRUCTOSE 3-PHOSPHATE; HEXOSE PHOSPHATE; SORBITOL 3 PHOSPHATE; SORBITOL 3-PHOSPHATE;

AGING; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DIABETES MELLITUS; GLUCOSE METABOLISM; LENS; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATE METABOLISM; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; REFERENCE VALUE; SPRAGUE DAWLEY RAT;

AGING; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; FRUCTOSEPHOSPHATES; HEXOSEPHOSPHATES; LENS, CRYSTALLINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES;

EID: 0029665966     PISSN: 00303747     EISSN: 14230259     Source Type: Journal    
DOI: 10.1159/000267874     Document Type: Article

References (10)

1. 31P NMR studies of the diabetic lens, Magn Reson Med 1988;6: 435-444.
2. Szwergold BS, Kappler F, Brown TR, Pfeffer P, Osman SF: Identification of D-sorbitol-3-phosphate in the normal and diabetic mammalian lens, J Biol Chem 1989;264: 9278-9282.
3. Szwergold BS, Kappler F, Brown TR: Identification of fructosc-3-phosphate in the lens of diabetic rats, Science 1990;247:451-454.
4. Tsubota K, Yoshida M, Toda T, Ono M, Kajiwara K, Cheng H-M: Aldose reductase inhibition and the phosphorus-31 profile of the intact rat lens, Ophthalmic Res 1993;25: 393-399.
5. Petersen A, Szwergold BS, Kappler F, Wcingartcn M, Brown TR: Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes, J Biol Chem 1990;265:17424-17427.
6. Gonzalez RG, Barnett PA, Cheng H-M, Chylack LT Jr.: Altered phosphate metabolism in the lens exposed to high glucose and its prevention by an aldose reductase inhibitor, Exp Eye Res 1984:39:553-562.
7. Cheng H-M, Gonzalez RG: Phosphorus-31 profiles of normal and diabetic human lenses, Med Sci Res 1991:19:91-92.
8. Lai S, Szwergold BS, Taylor AH, Randall WC, Kappler F, Brown TR: Production of fructose and fructose-3-phosphate in maturing rat lenses, Invest Ophthalmol Vis Sci 1995;36: 969-973.
9. Cheng H-M, Yoshida A, Xiong H, Gonzalez RG: The effect of insulin and aldose reductase inhibition on the phosphate metabolism of strcp-tozotocin-diabetic rat lens, Exp Eye Res 1991;53:805-808.
10. Cheng H-M, Hirose T, Xiong H: Generation of α-L,-glycerophosphate in the lens, Exp Eye Res 1989;49