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Volumn 18, Issue 2, 2008, Pages 161-168

Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer

Author keywords

Colon cancer; Thymidylate synthase; Tumor recurrence

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FLUOROURACIL; THYMIDYLATE SYNTHASE;

EID: 38149024196     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282f4aea6     Document Type: Article
Times cited : (49)

References (41)
  • 1
    • 33846457870 scopus 로고    scopus 로고
    • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57:43-66.
    • Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007; 57:43-66.
  • 3
    • 34250210799 scopus 로고    scopus 로고
    • Kuebler JP, Wieand HS, O'Connell MJ, Smith RE, Colangelo LH, Yothers G, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007; 25:2198-2204.
    • Kuebler JP, Wieand HS, O'Connell MJ, Smith RE, Colangelo LH, Yothers G, et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007; 25:2198-2204.
  • 4
    • 0028956045 scopus 로고    scopus 로고
    • Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Tangen CM, et al. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 1995; 122:321-326.
    • Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Tangen CM, et al. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Ann Intern Med 1995; 122:321-326.
  • 6
    • 0017716458 scopus 로고
    • Thymidylate synthetase: A target enzyme in cancer chemotherapy
    • Danenberg PV. Thymidylate synthetase: a target enzyme in cancer chemotherapy. Biochim Biophys Acta 1977; 473:73-92.
    • (1977) Biochim Biophys Acta , vol.473 , pp. 73-92
    • Danenberg, P.V.1
  • 7
    • 23844544276 scopus 로고    scopus 로고
    • Pharmacogenomics of thymidylate synthase in cancer treatment
    • Danenberg PV. Pharmacogenomics of thymidylate synthase in cancer treatment. Front Biosci 2004; 9:2484-2494.
    • (2004) Front Biosci , vol.9 , pp. 2484-2494
    • Danenberg, P.V.1
  • 8
    • 0037990003 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: A novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy
    • Cohen V, Panet-Raymond V, Sabbaghian N, Morin I, Batist G, Rozen R. Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy. Clin Cancer Res 2003; 9:1611-1615.
    • (2003) Clin Cancer Res , vol.9 , pp. 1611-1615
    • Cohen, V.1    Panet-Raymond, V.2    Sabbaghian, N.3    Morin, I.4    Batist, G.5    Rozen, R.6
  • 9
    • 0035412398 scopus 로고    scopus 로고
    • Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism
    • Ulrich CM, Yasui Y, Storb R, Schubert MM, Wagner JL, Bigler J, et al. Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism. Blood 2001; 98:231-234.
    • (2001) Blood , vol.98 , pp. 231-234
    • Ulrich, C.M.1    Yasui, Y.2    Storb, R.3    Schubert, M.M.4    Wagner, J.L.5    Bigler, J.6
  • 11
    • 0034048729 scopus 로고    scopus 로고
    • Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
    • Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 2000; 6:1322-1327.
    • (2000) Clin Cancer Res , vol.6 , pp. 1322-1327
    • Salonga, D.1    Danenberg, K.D.2    Johnson, M.3    Metzger, R.4    Groshen, S.5    Tsao-Wei, D.D.6
  • 12
    • 0036534108 scopus 로고    scopus 로고
    • Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
    • Edler D, Glimelius B, Hallstrom M, Jakobsen A, Johnston PG, Magnusson I, et al. Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 2002; 20:1721-1728.
    • (2002) J Clin Oncol , vol.20 , pp. 1721-1728
    • Edler, D.1    Glimelius, B.2    Hallstrom, M.3    Jakobsen, A.4    Johnston, P.G.5    Magnusson, I.6
  • 13
    • 0141455146 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: Predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Kornmann M, Schwabe W, Sander S, Kron M, Strater J, Polat S, et al. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res 2003; 9:4116-4124.
    • (2003) Clin Cancer Res , vol.9 , pp. 4116-4124
    • Kornmann, M.1    Schwabe, W.2    Sander, S.3    Kron, M.4    Strater, J.5    Polat, S.6
  • 14
    • 18344376180 scopus 로고    scopus 로고
    • Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors
    • Kralovanszky J, Koves I, Orosz Z, Katona C, Toth K, Rahoty P, et al. Prognostic significance of the thymidylate biosynthetic enzymes in human colorectal tumors. Oncology 2002; 62:167-174.
    • (2002) Oncology , vol.62 , pp. 167-174
    • Kralovanszky, J.1    Koves, I.2    Orosz, Z.3    Katona, C.4    Toth, K.5    Rahoty, P.6
  • 15
    • 0036164591 scopus 로고    scopus 로고
    • Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung
    • Nakagawa T, Tanaka F, Otake Y, Yanagihara K, Miyahara R, Matsuoka K, et al. Prognostic value of thymidylate synthase expression in patients with p-stage I adenocarcinoma of the lung. Lung Cancer 2002; 35:165-170.
    • (2002) Lung Cancer , vol.35 , pp. 165-170
    • Nakagawa, T.1    Tanaka, F.2    Otake, Y.3    Yanagihara, K.4    Miyahara, R.5    Matsuoka, K.6
  • 16
    • 0029122937 scopus 로고
    • Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase
    • Horie N, Aiba H, Oguro K, Hojo H, Takeishi K. Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5′-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 1995; 20:191-197.
    • (1995) Cell Struct Funct , vol.20 , pp. 191-197
    • Horie, N.1    Aiba, H.2    Oguro, K.3    Hojo, H.4    Takeishi, K.5
  • 17
    • 0033427561 scopus 로고    scopus 로고
    • Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers
    • Kawakami K, Omura K, Kanehira E, Watanabe Y. Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res 1999; 19:3249-3252.
    • (1999) Anticancer Res , vol.19 , pp. 3249-3252
    • Kawakami, K.1    Omura, K.2    Kanehira, E.3    Watanabe, Y.4
  • 18
    • 0035671827 scopus 로고    scopus 로고
    • Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression
    • Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, et al. Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res 2001; 7:4096-4101.
    • (2001) Clin Cancer Res , vol.7 , pp. 4096-4101
    • Kawakami, K.1    Salonga, D.2    Park, J.M.3    Danenberg, K.D.4    Uetake, H.5    Brabender, J.6
  • 19
    • 0141507954 scopus 로고    scopus 로고
    • Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    • Kawakami K, Watanabe G. Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 2003; 63:6004-6007.
    • (2003) Cancer Res , vol.63 , pp. 6004-6007
    • Kawakami, K.1    Watanabe, G.2
  • 20
    • 0037567591 scopus 로고    scopus 로고
    • A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity
    • Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ, et al. A novel single nucleotide polymorphism within the 5′ tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 2003; 63:2898-2904.
    • (2003) Cancer Res , vol.63 , pp. 2898-2904
    • Mandola, M.V.1    Stoehlmacher, J.2    Muller-Weeks, S.3    Cesarone, G.4    Yu, M.C.5    Lenz, H.J.6
  • 21
    • 2442480694 scopus 로고    scopus 로고
    • A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    • Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Yu MC, Iqbal S, et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 2004; 14:319-327.
    • (2004) Pharmacogenetics , vol.14 , pp. 319-327
    • Mandola, M.V.1    Stoehlmacher, J.2    Zhang, W.3    Groshen, S.4    Yu, M.C.5    Iqbal, S.6
  • 22
    • 34547616313 scopus 로고    scopus 로고
    • MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians
    • Markan S, Sachdeva M, Sehrawat BS, Kumari S, Jain S, Khullar M. MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians. Mol Cell Biochem 2007; 302:125-131.
    • (2007) Mol Cell Biochem , vol.302 , pp. 125-131
    • Markan, S.1    Sachdeva, M.2    Sehrawat, B.S.3    Kumari, S.4    Jain, S.5    Khullar, M.6
  • 23
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern LL, Mason JB, Selhub J, Choi SW. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Biomarkers Prev 2000; 9:849-853.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.W.4
  • 25
    • 13844270527 scopus 로고    scopus 로고
    • Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation
    • Stephens M, Scheet P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet 2005; 76:449-462.
    • (2005) Am J Hum Genet , vol.76 , pp. 449-462
    • Stephens, M.1    Scheet, P.2
  • 26
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001; 68:978-989.
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 27
    • 0035860142 scopus 로고    scopus 로고
    • A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
    • Iacopetta B, Grieu F, Joseph D, Elsaleh H. A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 2001; 85:827-830.
    • (2001) Br J Cancer , vol.85 , pp. 827-830
    • Iacopetta, B.1    Grieu, F.2    Joseph, D.3    Elsaleh, H.4
  • 28
    • 1442290323 scopus 로고    scopus 로고
    • Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
    • Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 2004; 22:529-536.
    • (2004) J Clin Oncol , vol.22 , pp. 529-536
    • Popat, S.1    Matakidou, A.2    Houlston, R.S.3
  • 29
    • 21044434731 scopus 로고    scopus 로고
    • Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy
    • Kawakami K, Graziano F, Watanabe G, Ruzzo A, Santini D, Catalano V, et al. Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy. Clin Cancer Res 2005; 11:3778-3783.
    • (2005) Clin Cancer Res , vol.11 , pp. 3778-3783
    • Kawakami, K.1    Graziano, F.2    Watanabe, G.3    Ruzzo, A.4    Santini, D.5    Catalano, V.6
  • 30
    • 25144481273 scopus 로고    scopus 로고
    • Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil
    • Hitre E, Budai B, Adleff V, Czegledi F, Horvath Z, Gyergyay F, et al. Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. Pharmacogenet Genomics 2005; 15:723-730.
    • (2005) Pharmacogenet Genomics , vol.15 , pp. 723-730
    • Hitre, E.1    Budai, B.2    Adleff, V.3    Czegledi, F.4    Horvath, Z.5    Gyergyay, F.6
  • 31
    • 0035868667 scopus 로고    scopus 로고
    • Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    • Villafranca E, Okruzhnov Y, Dominguez MA, Garcia-Foncillas J, Azinovic I, Martinez E, et al. Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer. J Clin Oncol 2001; 19:1779-1786.
    • (2001) J Clin Oncol , vol.19 , pp. 1779-1786
    • Villafranca, E.1    Okruzhnov, Y.2    Dominguez, M.A.3    Garcia-Foncillas, J.4    Azinovic, I.5    Martinez, E.6
  • 32
    • 14944380124 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity
    • Jakobsen A, Nielsen JN, Gyldenkerne N, Lindeberg J. Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 2005; 23:1365-1369.
    • (2005) J Clin Oncol , vol.23 , pp. 1365-1369
    • Jakobsen, A.1    Nielsen, J.N.2    Gyldenkerne, N.3    Lindeberg, J.4
  • 33
    • 7244258790 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in the 50 tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients
    • Marcuello E, Altes A, del Rio E, Cesar A, Menoyo A, Baiget M. Single nucleotide polymorphism in the 50 tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. Int J Cancer 2004; 112:733-737.
    • (2004) Int J Cancer , vol.112 , pp. 733-737
    • Marcuello, E.1    Altes, A.2    del Rio, E.3    Cesar, A.4    Menoyo, A.5    Baiget, M.6
  • 34
    • 33645750172 scopus 로고    scopus 로고
    • Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment
    • Dotor E, Cuatrecases M, Martinez-Iniesta M, Navarro M, Vilardell F, Guino E, et al. Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment. J Clin Oncol 2006; 24:1603-1611.
    • (2006) J Clin Oncol , vol.24 , pp. 1603-1611
    • Dotor, E.1    Cuatrecases, M.2    Martinez-Iniesta, M.3    Navarro, M.4    Vilardell, F.5    Guino, E.6
  • 35
    • 0032759779 scopus 로고    scopus 로고
    • Clinicopathological differences between colonic and rectal carcinomas: Are they based on the same mechanism of carcinogenesis?
    • Konishi K, Fujii T, Boku N, Kato S, Koba I, Ohtsu A, et al. Clinicopathological differences between colonic and rectal carcinomas: are they based on the same mechanism of carcinogenesis? Gut 1999; 45:818-821.
    • (1999) Gut , vol.45 , pp. 818-821
    • Konishi, K.1    Fujii, T.2    Boku, N.3    Kato, S.4    Koba, I.5    Ohtsu, A.6
  • 36
    • 33645727994 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms: Genomic predictors of clinical response to fluoropyrimidine-based chemotherapy?
    • Marcuello E, Altes A, Menoyo A, Rio ED, Baiget M. Methylenetetrahydrofolate reductase gene polymorphisms: genomic predictors of clinical response to fluoropyrimidine-based chemotherapy? Cancer Chemother Pharmacol 2006; 57:835-840.
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 835-840
    • Marcuello, E.1    Altes, A.2    Menoyo, A.3    Rio, E.D.4    Baiget, M.5
  • 38
    • 0842268401 scopus 로고    scopus 로고
    • Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene
    • Uchida K, Hayashi K, Kawakami K, Schneider S, Yochim JM, Kuramochi H, et al. Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin Cancer Res 2004; 10:433-439.
    • (2004) Clin Cancer Res , vol.10 , pp. 433-439
    • Uchida, K.1    Hayashi, K.2    Kawakami, K.3    Schneider, S.4    Yochim, J.M.5    Kuramochi, H.6
  • 39
    • 0142150084 scopus 로고    scopus 로고
    • Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer
    • Chen J, Hunter DJ, Stampfer MJ, Kyte C, Chan W, Wetmur JG, et al. Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2003; 12:958-962.
    • (2003) Cancer Epidemiol Biomarkers Prev , vol.12 , pp. 958-962
    • Chen, J.1    Hunter, D.J.2    Stampfer, M.J.3    Kyte, C.4    Chan, W.5    Wetmur, J.G.6
  • 40
    • 4444339951 scopus 로고    scopus 로고
    • Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy
    • Lecomte T, Ferraz JM, Zinzindohoue F, Loriot MA, Tregouet DA, Landi B, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 2004; 10:5880-5888.
    • (2004) Clin Cancer Res , vol.10 , pp. 5880-5888
    • Lecomte, T.1    Ferraz, J.M.2    Zinzindohoue, F.3    Loriot, M.A.4    Tregouet, D.A.5    Landi, B.6
  • 41
    • 0037096858 scopus 로고    scopus 로고
    • Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas
    • Ulrich CM, Bigler J, Bostick R, Fosdick L, Potter JD. Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res 2002; 62:3361-3364.
    • (2002) Cancer Res , vol.62 , pp. 3361-3364
    • Ulrich, C.M.1    Bigler, J.2    Bostick, R.3    Fosdick, L.4    Potter, J.D.5


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