Constitutional thinness: Unusual human phenotype of low bone quality

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 1, 2008, Pages 110-117

  Galusca, Bogdan ^a,c   Zouch, Mohamed ^b   Germain, Natacha ^a   Bossu, Cecile ^a   Frere, Delphine ^a   Lang, Francois ^a   Lafage Proust, Marie Helene ^b   Thomas, Thierry ^b   Vico, Laurence ^b   Estour, Bruno ^a  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^b INSERM   (France)

^c GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CARBOXY TERMINAL TELOPEPTIDE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR;

ADULT; ARTICLE; BODY MASS; BONE DENSITY; BONE STRENGTH; BONE TURNOVER; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR; HUMAN; LUMBAR SPINE; PARAMETER; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; RADIUS; TIBIA;

EID: 38148998649     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-1591     Document Type: Article

References (44)

1. Peacock M, Turner CH, Econs MJ, Foroud T 2002 Genetics of osteoporosis. Endocr Rev 23:303-326
2. Ravn P, Cizza G, Bjarnason NH, Thompson D, Daley M, Wasnich RD, McClung M, Hosking D, Yates AJ, Christiansen C 1999 Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res 14:1622-1627
3. Crilly RG, Delaquerriere-Richardson L 1990 Current bone mass and body weight changes in alcoholic males. Calcif Tissue Int 46:169-172
4. Thomas J, Doherty SM 2003 HIV infection - a risk factor for osteoporosis. J Acquir Immune Defic Syndr 33:281-291
5. Andreassen H, Hylander E, Rix M 1999 Gender, age, and body weight are the major predictive factors for bone mineral density in Crohn's disease: a case-control cross-sectional study of 113 patients. Am J Gastroenterol 94:824-828
6. Anker SD, Clark AL, Teixeira MM, Hellewell PG, Coats AJ 1999 Loss of bone mineral in patients with cachexia due to chronic heart failure. Am J Cardiol 83:612-615
7. Rigotti NA, Nussbaum SR, Herzog DB, Neer RM 1984 Osteoporosis in women with anorexia nervosa. N Engl J Med 311:1601-1606
8. Seeman E, Szmukler GI, Formica C, Tsalamandris C, Mestrovic R 1992 Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise. J Bone Miner Res 7:1467-1474
9. Carmichael KA, Carmichael DH 1995 Bone metabolism and osteopenia in eating disorders. Medicine (Baltimore) 74:254-267
10. Galusca B, Bossu C, Germain N, Kadem M, Frere D, Lafage-Proust MH, Lang F, Estour B 2006 Age-related differences in hormonal and nutritional impact on lean anorexia nervosa bone turnover uncoupling. Osteoporos Int 17:888-896
11. Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A 1999 The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 84:4489-4496
12. Apfelbaum M, Sachet P 1982 [Constitutional thinness]. Rev Prat 32:245-247 (French)
13. Tolle V, Kadem M, Bluet-Pajot MT, Frere D, Foulon C, Bossu C, Dardennes R, Mounier C, Zizzari P, Lang F, Epelbaum J, Estour B 2003 Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. J Clin Endocrinol Metab 88:109-116
14. Bossu C, Galusca B, Normand S, Germain N, Collet P, Frere D, Lang F, Laville M, Estour B 2007 Energy expenditure adjusted for body composition differentiates constitutional thinness from both normal subjects and anorexia nervosa. Am J Physiol Endocrinol Metab 292:E132-E137
15. 1995 Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 854:1-452
16. American Psychiatric Association 1994 Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association
17. Viricel J, Bossu C, Galusca B, Kadem M, Germain N, Nicolau A, Millot L, Vergely N, Lassandre S, Carrot G, Lang F, Estour B 2005 [Retrospective study of anorexia nervosa: reduced mortality and stable recovery rates]. Presse Med 34(20 Pt 1):1505-1510 (French)
18. William DL, Robert AA, Ghada El-Hajj F, Anthony H, David LK, Michael M, Paul DM, Nelson BW 2005 Application of the 1994 WHO Classification to Populations Other Than Postmenopausal Caucasian Women: The 2005 ISCD Official Positions. J Clin Densitom 9:22-30
19. Laib A, Hauselmann HJ, Ruegsegger P 1998 In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 6:329-337
20. Schoenau E, Neu CM, Rauch F, Manz F 2001 The development of bone strength at the proximal radius during childhood and adolescence. J Clin Endocrinol Metab 86:613-618
21. Siu WS, Qin L, Leung KS 2003 pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength. J Bone Miner Metab 21:316-322
22. Bagi CM, Hanson N, Andresen C, Pero R, Lariviere R, Turner CH, Laib A 2006 The use of micro-CT to evaluate cortical bone geometry and strength in nude rats: correlation with mechanical testing, pQCT and DXA. Bone 38:136-144
23. Garnero P, Gineyts E, Riou JP, Delmas PD 1994 Assessment of bone resorption with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab 79:780-785
24. Vergely N, Lafage-Proust MH, Caillot-Augusseau A, Millot L, Lang F, Estour B 2002 Hypercorticism blunts circadian variations of osteocalcin regardless of nutritional status. Bone 30:428-435
25. Bonde M, Qvist P, Fledelius C, Riis BJ, Christiansen C 1995 Applications of an enzyme immunoassay for a new marker of bone resorption (CrossLaps): follow-up on hormone replacement therapy and osteoporosis risk assessment. J Clin Endocrinol Metab 80:864-868
26. Biadi O, Rossini R, Musumeci G, Frediani L, Masullo M, Ramacciotti CE, Dellosso L, Paoli R, Mariotti R, Cassano GB, Mariani M 2001 Cardiopulmonary exercise test in young women affected by anorexia nervosa. Ital Heart J 2:462-467
27. Schneider L, Heard I, Breart G, Henrion R 1979 [Maternal thinness and pregnancy]. Arch Fr Pediatr 36:1068-1074 (French)
28. Norgan NG 1994 Interpretation of low body mass indices: Australian aborigines. Am J Phys Anthropol 94:229-237
29. Gartner A, Maire B, Kameli Y, Traissac P, Delpeuch F 2001 Body composition unaltered for African women classified as 'normal but vulnerable' by body mass index and mid-upper-arm-circumference criteria. Eur J Clin Nutr 55:393-399
30. Hofbauer LC, Schoppet M 2004 Clinical implications of the osteoprotegerin/ RANKL/RANK system for bone and vascular diseases. JAMA 292:490-495
31. Misra M, Soyka LA, Miller KK, Herzog DB, Grinspoon S, De Chen D, Neubauer G, Klibanski A 2003 Serum osteoprotegerin in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 88:3816-3822
32. Milos G, Spindler A, Ruegsegger P, Seifert B, Muhlebach S, Uebelhart D, Hauselmann HJ 2005 Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16:783-790
33. Karlsson MK, Weigall SJ, Duan Y, Seeman E 2000 Bone size and volumetric density in women with anorexia nervosa receiving estrogen replacement therapy and in women recovered from anorexia nervosa. J Clin Endocrinol Metab 85:3177-3182
34. Biller BM, Saxe V, Herzog DB, Rosenthal DI, Holzman S, Klibanski A 1989 Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metab 68:548-554
35. Rappaport R, Prevot C, Czernichow P 1980 Somatomedin activity and growth hormone secretion. I. Changes related to body weight in anorexia nervosa. Acta Paediatr Scand 69:37-41
36. Holtkamp K, Mika C, Grzella I, Heer M, Pak H, Hebebrand J, Herpertz-Dahlmann B 2003 Reproductive function during weight gain in anorexia nervosa. Leptin represents a metabolic gate to gonadotropin secretion. J Neural Transm 110:427-435
37. Bakker I, Twisk JW, Van Mechelen W, Kemper HC 2003 Fat-free body mass is the most important body composition determinant of 10-yr longitudinal development of lumbar bone in adult men and women. J Clin Endocrinol Metab 88:2607-2613
38. Rucci N, Rufo A, Alamanou M, Teti A 2007 Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio. J Cell Biochem 100:464-473
39. Vico L, Collet P, Guignandon A, Lafage-Proust MH, Thomas T, Rehaillia M, Alexandre C 2000 Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts. Lancet 355:1607-1611
40. Bulik CM, Allison DB 2001 The genetic epidemiology of thinness. Obes Rev 2:107-115
41. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Pernod J, Dubois F, Alexandre C 1998 Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Clin Chem 44:578-585
42. Parker E, Phillips DI, Cockington RA, Cull C, Poulton J 2005 A common mitochondrial DNA variant is associated with thinness in mothers and their 20-yr-old offspring. Am J Physiol Endocrinol Metab 289:E1110-E1114
43. Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heaney RP 1994 Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a crosssectional model. J Clin Invest 93:799-808
44. Lucas AR, Melton 3rd LJ, Crowson CS, O'Fallon WM 1999 Long-term fracture risk among women with anorexia nervosa: a population-based cohort study. Mayo Clin Proc 74:972-97