Finding genetic modifiers of cystic fibrosis

New England Journal of Medicine

Volumn 353, Issue 14, 2005, Pages 1509-1511

  Haston, Christina K ^a,b   Hudson, Thomas J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS; EDITORIAL; GENE DELETION; GENE IDENTIFICATION; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; PRIORITY JOURNAL;

CYSTIC FIBROSIS; FORCED EXPIRATORY VOLUME; GENOTYPE; HUMANS; LUNG DISEASES; TRANSFORMING GROWTH FACTOR BETA;

EID: 25844458371     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe058185     Document Type: Editorial

References (14)

1. Kerem B, Rommens JM, Buchanan JA, et al. Identification of the cystic fibrosis gene: genetic analysis. Science 1989;245:1073-80.
2. Drumm ML, Konstan MW, Schluchter MD, et al. Genetic modifiers of lung disease in cystic fibrosis. N Engl J Med 2005;353:1443-53.
3. Cystic fibrosis mutation database. (Accessed September 15, 2005, at http://www.genet.sickkids.on.ca/cftr/.)
4. Rowntree RK, Harris A. The phenotypic consequences of CFTR mutations. Ann Hum Genet 2003;67:471-85.
5. 508). N Engl J Med 1990;323:1517-22.
6. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K. A comprehensive review of genetic association studies. Genet Med 2002;4:45-61.
7. Wahl SM, Swisher J, McCartney-Francis N, Chen W. TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cells. J Leukoc Biol 2004;76:15-24.
8. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor β in human disease. N Engl J Med 2000;342:1350-8.
9. Bartram U, Speer CP. The role of transforming growth factor beta in lung development and disease. Chest 2004;125:754-65.
10. Kinoshita A, Saito T, Tomita H, et al. Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease. Nat Genet 2000;26:19-20.
11. Grutters JC, du Bois RM. Genetics of fibrosing lung diseases. Eur Respir J 2005;25:915-27.
12. Celedon JC, Lange C, Raby BA, et al. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet 2004;13:1649-56.
13. Burgess HA, Daugherty LE, Thatcher TH, et al. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2005;288:L1146-L1153.
14. Watts KL, Sampson EM, Schultz GS, Spiteri MA. Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts. Am J Respir Cell Mol Biol 2005;32:290-300.